CD38 increases as we age, driving down NAD+ levels CD38 is an enzyme that responds to inflammation, and consumes NAD+. Researchers have long known that
(Pencina et al., 2022 | The Journals of Gerontology) NMN doses of 1,000 mg taken once daily doubles NAD+ levels (middle graph). When taken twice
There has been little, if any, head to head research published comparing Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR). However, Dr. Sinclair recently said he
There has been few, if any, head to head research published comparing Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR). However, Dr. Sinclair recently said he
Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women, Science, April 22, 2021 NAD+ is the critical cellular component for cellular homeostasis, which declines during
If not protected, NMN and NR supplements are almost entirely degraded to NAM (Nicotinamide) before reaching tissues beyond the liver. While NAM is beneficial for
This recent study found that in endothelial cells, the extracellular conversion of NMN to NR by CD73 enzyme in the cell membrane is a key
Justin Bieber gets weekly IV drips of NAD+ to help with the effects of his years of substance abuse Justin Bieber opened up
Much of the attention on the benefits of restoring NAD+ levels focus on its role in activating sirtuins. However, scientific research shows that NAD supplementation
The first study of NMN in humans was just published. https://www.jstage.jst.go.jp/…/advpub_EJ19-03…/_pdf/-char/en This japanese study looked at a single dose of 100, 250, or 500 mg
This study was just published that documented changes in plasma and urine levels of NAD+ and its metabolites during and after 750 mg NAD+ intravenous
Restoring NAD+ levels in older animals and humans is at the center of efforts to slow or even stop the effects of aging. One method
Yes, NMN can cross the cell membrane intact This research was just published that found an enzyme named Slc12a8 that can transport a small quantity
Exogenous nicotinamide adenine dinucleotide regulates energy metabolism via hypothalamic Connexin 43. There are some very important findings coming out of this research: Exogenous NAD+ definitely
Effects of Chronic NAD Supplementation on Energy Metabolism and Diurnal Rhythm in Obese Mice In a study published in 2018, scientists gave obese mice 1
Do NMN and NAD⁺ have different effects on the body? Researchers use supplementation with NMN, NR and NAD⁺ to restore levels of NAD⁺ in mice,
CD38 increases as we age, driving down NAD+ levels CD38 is an enzyme that responds to inflammation, and consumes NAD+. Researchers have long known that
(Pencina et al., 2022 | The Journals of Gerontology) NMN doses of 1,000 mg taken once daily doubles NAD+ levels (middle graph). When taken twice
There has been little, if any, head to head research published comparing Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR). However, Dr. Sinclair recently said he
Intercellular communication: communication between cells All species of animals, including the human being, are multicellular organisms (an organism that consists of more than one cell).
Stem cells – the source of tissue homeostasis In human tissue, there are various highly differentiated cells specialized to perform distinct functions. For example, there
TMG – the insurance policy against loss of methyl groups TMG is one of the most important ways to restore methyl groups because as the
Cellular senescence – Aging at the cellular level Cellular senescence is generally defined as a loss of the ability to divide followed by some secretive
There has been few, if any, head to head research published comparing Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR). However, Dr. Sinclair recently said he
NEAR TERM – INTRACELLULAR NAD+ TEST Maintaining high NAD+ levels provides the fuel your cells need to repair damage and fight the aging process. Besides
Mitochondria – more than power plants in cells Mitochondria are the large organelles that exist in most human cells. They are the critical organelles that
Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women, Science, April 22, 2021 NAD+ is the critical cellular component for cellular homeostasis, which declines during
If not protected, NMN and NR supplements are almost entirely degraded to NAM (Nicotinamide) before reaching tissues beyond the liver. While NAM is beneficial for
NAD+ precursors and healthy aging Nicotinamide adenine dinucleotide (NAD+) is a coenzyme found in all living cells. It is a critical coenzyme for energy metabolism
Overview Currently, available evidence strongly supports the idea that anabolic signaling (the signal that promotes growth and proliferation) accelerates aging, and decreased nutrient signaling extends
Cells are “factories” and proteins are “machines” In previous parts, we mainly discussed the mishaps that accumulate on the genome that cause aging. In this
What is epigenetics? It is well-known that the DNA sequence inside of the nucleus encodes all the information required for life. However, why do different
Telomere shortening is probably the most famous hallmark of aging, but what is the telomere’s original function? Telomeres protect the ends of chromosomes Every
Aging characterized by gradual loss of physiological integrity Aging is characterized by a gradual loss of physiological integrity, resulting in impaired biological function and increased
Above is a response by Dr. Bradley Stanfield to some lingering questions that resulted from an interview he had of Dr. Charles Brenner on Dec.
This recent study found that in endothelial cells, the extracellular conversion of NMN to NR by CD73 enzyme in the cell membrane is a key
An essential compound—known as NAD+—has found its way into skincare and is being hailed as a “true cosmeceutical.”
Much of the attention on the benefits of restoring NAD+ levels focus on its role in activating sirtuins. However, scientific research shows that NAD supplementation
The first study of NMN in humans was just published. https://www.jstage.jst.go.jp/…/advpub_EJ19-03…/_pdf/-char/en This japanese study looked at a single dose of 100, 250, or 500 mg
This study was just published that documented changes in plasma and urine levels of NAD+ and its metabolites during and after 750 mg NAD+ intravenous
Restoring NAD+ levels in older animals and humans is at the center of efforts to slow or even stop the effects of aging. One method
This research was published in January 2019 that found an enzyme named Slc12a8 that can transport a small quantity of Nicotinamide Mononucleotide (NMN) directly into
Yes, NMN can cross the cell membrane intact This research was just published that found an enzyme named Slc12a8 that can transport a small quantity
Exogenous nicotinamide adenine dinucleotide regulates energy metabolism via hypothalamic Connexin 43. There are some very important findings coming out of this research: Exogenous NAD+ definitely
Effects of Chronic NAD Supplementation on Energy Metabolism and Diurnal Rhythm in Obese Mice In a study published in 2018, scientists gave obese mice 1
The main ingredient in Elysium Health’s Basis is Nicotinamide Riboside (NR). Elysium Health is only one of several companies selling Nicotinamide Riboside (NR). Their main
Do NMN and NAD⁺ have different effects on the body? Researchers use supplementation with NMN, NR and NAD⁺ to restore levels of NAD⁺ in mice,
