How is NAD+ an Effective Supplement if it isn’t bioavailable? – RENUE BY SCIENCE – Bioavailable NAD+ Boosters
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How is NAD+ an Effective Supplement if it isn’t bioavailable?

When NAD is digested in the stomach, the first step is to NMN.

NMN is digested to NR.

Then, NR to NAM.

So its a silly misconception that NR or NMN better survive digestion. It is simply not possible.

Research is clear now that orally, NAD+, NMN, and NR are ALL almost entirely digested to Nam in digestive system.

More bioavailable delivery methods like sublingual or liposomal are required to get more than 5% to the bloodstream intact.

Once in the bloodstream, NAD+ has several pathways to enter cells intact, or, be metabolized to NMN by the CD73 enzyme that is ubiquitous on the cell membrane, so it restores intracellular NAD+ levels as effectively as NR and NMN.

The advantage of NAD+ itself in the bloodstream is it is very stable. NR is quickly degraded to NAM in the blood, with NMN somewhere in the middle.

So, NAD+ makes a very effective supplement.

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