What’s the problem with taking NR & NMN in standard capsules? – RENUE BY SCIENCE – Bioavailable NAD+ Boosters
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What’s the problem with taking NR & NMN in standard capsules?

Taking NR and NMN capsules result in massive increases in NAM.

“The minute amount of dual-labeled NAD observed in muscle indicates that direct utilization of NR by the muscle does occur. However, oral NR dosing increased circulating NAM ~40-fold while NMN remained unchanged and NR was detected only at trace levels in the blood*. Thus, the majority of the orally administered NR that reaches the muscle appears to enter in the form of liberated NAM or as NMN”

NAM does have many benefits for humans, but excessive dosages may not be advisable.

“high doses of NAM can cause genomic instability, reduce cellular methyl pools, and cause insulin resistance through methylated NAM”

However, taking “normal” dosages (1,000 mg a day) of NR or NMN is likely not a significant problem.

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