NAD+ Forums

This new paper shows that NMN administration could significantly reduce tubular cell DNA damage and subsequent cellular senescence induced by hydrogen peroxide and hypoxia in human proximal tubular cells (HK-2 cells). The DNA damage inhibition, antiaging and anti-inflammatory effects of NMN were fur...

The reduced form of NMN (aka NMNH) is an NAD+ precursor that potentially outperforms the NMN. Recently the second paper on this topic was published https://pubs.acs.org/doi/10.1021/acs.jproteome.0c01037 It doesn't add much more information compared to the first paper (which is discussed in this arti...

Why did you call it rapamycin fast? Is rapamycin involved or you just mean to mimic the rapamycin treatment by fasting?
 

Cardiac fibrosis is a pathological hallmark of progressive heart diseases currently lacking effective treatment. Here is a new study shows that NMN could attenuate cardiac fibrosis in vivo and fibroblast activation in vitro by suppressing oxidative stress and acetylation in a NAD+/SIRT1-dependent ma...

I just found this nice review paper giving healthy lifestyle recommendations based on current knowledge on NAD. The best thing is that it is an open-access paper, no paywall!
https://www.hindawi.com/journals/omcl/2020/8819627/

This is the first paper showing that the removal of the senescent cell can alleviate brain inflammation and cognitive decline during aging. With AP20187 or with the senolytic cocktail Dasatinib and Quercetin, they observed that both strategies resulted in reduced senescent cell, microglial activatio...

Hi, flushing is a well-known side-effect of taking high dose of NAD precursor. It's harmless as long as it is due to NAD, instead of other ingredients in the product. It appears as a flush of red on the skin, which may be accompanied by an itching or burning sensation. Symptoms typically go away aft...

Hi Tim, welcome! in short: we don't know yet, but the sublingual is more promising than oral, based on current evidence. Full answer: As far as I know, there is currently no human study on sublingual NMN yet. However, there is a recently study shows that oral administration of NMN suffers from bacte...

https://pubmed.ncbi.nlm.nih.gov/33382023/ TMPRSS2 is gateway for SARS CoV-2 entry into the host cell. It causes proteolytic activation of spike protein and discharge of the peptide into host cell. The TMPRSS2 inhibition could be one of the approaches to stop the viral entry. In this study, they fou...

Impressive result! https://pubmed.ncbi.nlm.nih.gov/33381005/ Previous studies have reported the antioxidant, anti-inflammatory, and anti-cancer effects of fisetin. However, the therapeutic efficacy of fisetin in Parkinson's disease (PD) is unclear. In this study, researchers demonstrated that fiseti...