Search found 175 matches
- Mon Apr 12, 2021 12:00 am
- Forum: NMN
- Topic: NMN Attenuates Renal Interstitial Fibrosis
- Replies: 2
- Views: 5362
NMN Attenuates Renal Interstitial Fibrosis
This new paper shows that NMN administration could significantly reduce tubular cell DNA damage and subsequent cellular senescence induced by hydrogen peroxide and hypoxia in human proximal tubular cells (HK-2 cells). The DNA damage inhibition, antiaging and anti-inflammatory effects of NMN were fur...
- Tue Apr 06, 2021 12:13 pm
- Forum: NMN
- Topic: Second paper on NMNH
- Replies: 7
- Views: 9183
Second paper on NMNH
The reduced form of NMN (aka NMNH) is an NAD+ precursor that potentially outperforms the NMN. Recently the second paper on this topic was published https://pubs.acs.org/doi/10.1021/acs.jproteome.0c01037 It doesn't add much more information compared to the first paper (which is discussed in this arti...
- Thu Apr 01, 2021 4:03 am
- Forum: Fasting
- Topic: The 7 day rapamycin fast
- Replies: 25
- Views: 45301
Re: The 7 day rapamycin fast
Why did you call it rapamycin fast? Is rapamycin involved or you just mean to mimic the rapamycin treatment by fasting?
- Mon Mar 08, 2021 2:40 pm
- Forum: NMN
- Topic: NMN attenuates cardiac fibrosis
- Replies: 5
- Views: 7508
NMN attenuates cardiac fibrosis
Cardiac fibrosis is a pathological hallmark of progressive heart diseases currently lacking effective treatment. Here is a new study shows that NMN could attenuate cardiac fibrosis in vivo and fibroblast activation in vitro by suppressing oxidative stress and acetylation in a NAD+/SIRT1-dependent ma...
- Thu Feb 04, 2021 3:21 pm
- Forum: NAD+
- Topic: Healthy Lifestyle Recommendations: Do the Beneficial Effects Originate from NAD+ Amount at the Cellular Level?
- Replies: 3
- Views: 9978
Healthy Lifestyle Recommendations: Do the Beneficial Effects Originate from NAD+ Amount at the Cellular Level?
I just found this nice review paper giving healthy lifestyle recommendations based on current knowledge on NAD. The best thing is that it is an open-access paper, no paywall!
https://www.hindawi.com/journals/omcl/2020/8819627/
https://www.hindawi.com/journals/omcl/2020/8819627/
- Mon Jan 25, 2021 10:15 am
- Forum: Senolytics
- Topic: Senolytics alleviates age-related cognitive impairment
- Replies: 2
- Views: 8844
Senolytics alleviates age-related cognitive impairment
This is the first paper showing that the removal of the senescent cell can alleviate brain inflammation and cognitive decline during aging. With AP20187 or with the senolytic cocktail Dasatinib and Quercetin, they observed that both strategies resulted in reduced senescent cell, microglial activatio...
- Tue Jan 19, 2021 1:27 pm
- Forum: Renue NAD+ Skin Care
- Topic: Flushing (or other side effects) with Renue?
- Replies: 7
- Views: 15162
Re: Flushing (or other side effects) with Renue?
Hi, flushing is a well-known side-effect of taking high dose of NAD precursor. It's harmless as long as it is due to NAD, instead of other ingredients in the product. It appears as a flush of red on the skin, which may be accompanied by an itching or burning sensation. Symptoms typically go away aft...
- Tue Jan 19, 2021 1:15 pm
- Forum: NMN
- Topic: NMN Sublingual vs. Oral
- Replies: 4
- Views: 8356
Re: NMN Sublingual vs. Oral
Hi Tim, welcome! in short: we don't know yet, but the sublingual is more promising than oral, based on current evidence. Full answer: As far as I know, there is currently no human study on sublingual NMN yet. However, there is a recently study shows that oral administration of NMN suffers from bacte...
- Fri Jan 15, 2021 2:39 pm
- Forum: Senolytics
- Topic: Fisetin as entry inhibitor in COVID19 infection
- Replies: 4
- Views: 9151
Fisetin as entry inhibitor in COVID19 infection
https://pubmed.ncbi.nlm.nih.gov/33382023/ TMPRSS2 is gateway for SARS CoV-2 entry into the host cell. It causes proteolytic activation of spike protein and discharge of the peptide into host cell. The TMPRSS2 inhibition could be one of the approaches to stop the viral entry. In this study, they fou...
- Wed Jan 06, 2021 8:58 pm
- Forum: Senolytics
- Topic: Fisetin Regulates Gut Microbiota and shows Neuroprotective Effect on Parkinson's Disease
- Replies: 6
- Views: 11724
Fisetin Regulates Gut Microbiota and shows Neuroprotective Effect on Parkinson's Disease
Impressive result! https://pubmed.ncbi.nlm.nih.gov/33381005/ Previous studies have reported the antioxidant, anti-inflammatory, and anti-cancer effects of fisetin. However, the therapeutic efficacy of fisetin in Parkinson's disease (PD) is unclear. In this study, researchers demonstrated that fiseti...