NAD+ Forums

Cell Rep 2021 Aug 10 NAD+ supplement potentiates tumor-killing function by rescuing defective TUB-mediated NAMPT transcription in tumor-infiltrated T cells "...  Excitingly, both adoptive CAR-T and anti-PD1 immune checkpoint blockade mouse models demonstrate that NAD+ supplementation enhanced ...

Instability in NAD+metabolism leads to impaired cardiac mitochondrial function and communication "...In addition, we show that myocardial mtDNA damage in combination with high dosages of nicotinamide riboside (NR) causes inhibition of sirtuin activity due to accumulation of nicotinamide (NAM),...

Int Immunopharmacol 2021 Jun 11;98:107856.  doi: 10.1016/j.intimp.2021.107856. Nicotinamide mononucleotide-elicited NAMPT signaling activation aggravated adjuvant-induced arthritis in rats by affecting peripheral immune cells differentiation Supplement of nicotinamide mononucleotide (NMN), the dire...

looks like a race between two research groups for first publication: Luongo, T.S., Eller, J.M., Lu, M.  et al.    Nature  ( Published: 09 September 2020 ). https://doi.org/10.1038/s41586-020-2741-7 SLC25A51 is a mammalian mitochondrial NAD+ transporter Mitochondria require nicotinamide adenine dinuc...