Search found 205 matches

by rhett
Thu Mar 24, 2022 10:02 am
Forum: Miscellaneous Topics
Topic: Why liposomal? Could it actually hinder effects?
Replies: 8
Views: 11181

Why liposomal? Could it actually hinder effects?

It seems almost all of the newer RBS products are being formulated only as liposomal versions. I know that liposomal formulations are able to bypass the gut and enter the bloodstream more easily, but is this necessarily a desirable thing for all of these supplements? We're taking these in the first ...
by rhett
Sun Oct 31, 2021 7:10 pm
Forum: Miscellaneous Topics
Topic: An old question with new context: your wellness budget
Replies: 16
Views: 17818

Re: An old question with new context: your wellness budget

Been asking myself that as I consider trying weekly rapamycin dosing. With generics, 30mg can be had for about $150. 3mg dose once weekly makes that 10 weeks supply, or about $67/month. Added on to my NMN and pterostilbene that would take me close to $125 a month. Not terrible when you consider the ...
by rhett
Tue Oct 12, 2021 6:04 am
Forum: NMN
Topic: NMN sub lingual and cavities
Replies: 10
Views: 11852

Re: NMN sub lingual and cavities

Apparently ABS is switching back to the old, less acidic formula around the new year.
by rhett
Sun Oct 10, 2021 3:17 pm
Forum: NMN
Topic: NMN & Breast Cancer Survivor
Replies: 6
Views: 6363

Re: NMN & Breast Cancer Survivor

Dr Sinclair has said a few times that while he thinks NMN helps prevent cancer, he would be cautious with anyone who had an active cancer and defer 100% to the oncologists who can devise an overall treatment plan for that cancer.
by rhett
Sun Sep 26, 2021 6:46 am
Forum: Longevity
Topic: Dr Blagosklonny’s regimen
Replies: 3
Views: 5341

Dr Blagosklonny’s regimen

https://twitter.com/Blagosklonny/status/1441539123349790720?s=20 Rapamycin high dose intermittently Low-Carb or Low Carb/Cal diets, time-restricted, IF Physical exercise daily Sun, Sunbath/Vit D3 Metformin low/medium dose Angiotensin II inhibitors Aspirin low dose Lithium low dose DHEA, L-Ornithine ...
by rhett
Mon Sep 13, 2021 7:33 am
Forum: NMN
Topic: NMN intramuscular
Replies: 4
Views: 4636

Re: NMN intramuscular

I would find a doctor who offers nad+ treatments. Anything injected must be sterile and at an even higher purity than orally consumed compounds. Also it is unclear if NMN doesn’t actually need to go through the digestive tract to work. There is some evidence that NMN actually increases NAD+ through ...
by rhett
Sat Sep 11, 2021 2:05 pm
Forum: Longevity
Topic: BEZOS AND LONGEVITY
Replies: 12
Views: 11742

Re: BEZOS AND LONGEVITY

Yes we are living in exciting times as we will witness more scientific break throughs in aging and how to reverse it.    Yes, and the longevity race is still continuing even though we are presently all experiencing one of the worst worldwide pandemics to affect mankind.. If anything it still shows ...
by rhett
Wed Sep 08, 2021 4:28 pm
Forum: Longevity
Topic: BEZOS AND LONGEVITY
Replies: 12
Views: 11742

Re: BEZOS AND LONGEVITY

Yamanaka factors are being studied by Dr David Sinclair’s lab ( they regenerated an entire optic nerve which before has been completely impossible) and also a handful of other labs like Calico, the Google biotech offshoot. It is really great to see so multiple labs see promise in the same technology...
by rhett
Thu Aug 19, 2021 3:18 pm
Forum: Nutrition
Topic: Natural mTOR-inhibitors for the longevity ?.
Replies: 10
Views: 17390

Re: Natural mTOR-inhibitors for the longevity ?.

From what I understand rapamycin has different effects at different doses. When used once a week, it only inhibits mTOR1 ( that's what we want to inhibit). When used daily, it inhbits mTOR2 (that's the one we don't want to inhibit)
by rhett
Tue Aug 10, 2021 2:26 pm
Forum: Senolytics
Topic: Eliminating senescent cells may be harmful?
Replies: 16
Views: 21390

Re: Eliminating senescent cells may be harmful?

This is the premise of how they could potentially be a net harmful thing. I have no idea personally, I just had never considered that there may be less than positive long term effects: Here is the argument: 1) theoretically, senolytics should make things worse and 2) the available data support this ...