Search found 4 matches

by zisos
Sat Apr 11, 2020 6:00 am
Forum: NAD+ Preservers
Topic: Info on recent reports on increasing nad.
Replies: 10
Views: 31498

Re: Info on recent reports on increasing nad.

Before supplementing with a senolytic like fisetin or a CD38 inhibitor like apigenin, it would be nice to know whether you even have a problem with excessive levels of senescent cells due to aging. Unfortunately, there is currently no commercial test to check for levels of cellular senescence. Howe...
by zisos
Fri Apr 10, 2020 5:39 am
Forum: NAD+ Preservers
Topic: Info on recent reports on increasing nad.
Replies: 10
Views: 31498

Re: Info on recent reports on increasing nad.

I do not know if this would add to the effects of nad precursor benefits. But you can peruse. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609577/?fbclid=IwAR2lCgHsSnXiWzv9GC7Zy4wdmIcA5qaxksCgWq4QlFrGdy94mIzOIakXpQU It certainly will add to the effect of nad precursors. apigenin will inhibit cd38,...
by zisos
Fri Apr 10, 2020 5:29 am
Forum: NAD+ Preservers
Topic: Info on recent reports on increasing nad.
Replies: 10
Views: 31498

Re: Info on recent reports on increasing nad.

Supplementation with apigenin (inhibitor of CD38) might be a more cost-effective and more appropriate way of keeping NAD+ level high. Most likely, a lower level of NAD+ as we age is due to higher CD38 as we age. Treating the problem (high CD38) is probably more appropriate than treating the symptom...
by zisos
Thu Apr 09, 2020 4:03 pm
Forum: NAD+ Preservers
Topic: Info on recent reports on increasing nad.
Replies: 10
Views: 31498

Re: Info on recent reports on increasing nad.

Supplementation with apigenin (inhibitor of CD38) might be a more cost-effective and more appropriate way of keeping NAD+ level high. Most likely, a lower level of NAD+ as we age is due to higher CD38 as we age. Treating the problem (high CD38) is probably more appropriate than treating the symptom ...