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Blue Zones are geographic regions where people supposedly have higher longevity, according to a 2016 review published in the American Journal of Lifestyle Medicine. For example, researchers identified the Italian island of Sardinia as the region with the highest concentration of male centenarians, o...

In a first of its kind randomized controlled trial an international team of researchers shows that caloric restriction can slow the pace of aging in healthy adults. The CALERIE intervention slowed pace of aging measured from participants' blood DNA methylation using an algorithm. The trial randomize...

An analysis of the life spans and social lives of nearly 1,000 mammal species shows that species that live in groups, such as horses and chimpanzees, tend to live longer than solitary beasts, like weasels and hedgehogs. The researchers found 31 genes whose relative activity levels were correlated wi...

Scientists have discovered that cytomegalovirus (CMV) can be used as a monthly inhaled gene therapy for delivering the exogenous genes TERT or FST safely and effectively. Exogenous telomerase reverse transcriptase or follistatin genes were safely and effectively delivered in mice. The treatment sign...

A team of British and Italian researchers has found that a specific mutated gene in so-called "superagers" who make it into their centenarian years could be used to help those with heart failure turn back the clock by ten years. The findings suggest that introducing a protein to the cells ...

A new study shows that LAV-BPIFB4 gene may exert its cardioprotective effects by promoting the formation of new blood vessels and reducing the number of blood vessel cells that have become senescent and stopped multiplying. Inducing the expression of LAV-BPIFB4 in aged mice led to improvements in ca...

New research findings, published on January 20 in the journal Aging Cell, show that animals treated with rilmenidine, currently used to treat hypertension (high blood pressure), at young and older ages increase lifespan and improve health markers, mimicking the effects of caloric restriction. Unlike...

In a University of Auckland study, mice were given alpelisib - currently used to treat cancer - which increased their lifespan by an average of 10 percent, compared to mice with the same diet that were not given the drug. The results, published in international journal Nature Ageing, found the mice ...

A new study of longevity in rockfish, which includes some species that live more than 200 years and others that live fewer than a dozen, identifies a set of genes controlling their aging process that has led to the discovery of a previously unappreciated group of genes associated with extended lifes...

The mainstreaming of longevity is being driven by advancements in biotechnology and genetics, as well as by the actions of "leading ladies" in the field, such as Maria Konovalenko, who is working to promote the idea of "healthy aging" through her research on mice and through her ...