NAD+ Forums

https://pubmed.ncbi.nlm.nih.gov/32926843/ Fisetin protects the heart against ischemia-reperfusion injury and the evident cardioprotection is PPAR-γ dependant. In conclusion, this study has revealed a prime mechanism involved in the cardioprotective effects of fisetin. Hence, Fisetin may be evaluated...

This might be interesting. Young.ai, an iPhone app created by Hong Kong–based technology company Deep Longevity, will use a variety of “biological clock” algorithms to compute a user’s biological age based on everything from blood samples and data collected from wearable fitness trackers to a simple...

A recent research! I remember someone asked about hepatic fibrosis months ago, and now we have some answer in this paper.  The present study aimed to investigate the protective role of the flavonoid fisetin (FI) on inflammation-mediated metabolic diseases, especially tissue fibrosis and insulin resi...

Check this new paper on partial reprogramming! It's a proof of concept that partial reprogramming can safely reverse aging! Partial reprogramming induces a steady decline in epigenetic age before loss of somatic identity https://onlinelibrary.wiley.com/doi/full/10.1111/acel.12877 Induced pluripoten...

Check this new paper on partial reprogramming! It's a proof of concept that partial reprogramming can safely reverse aging! Partial reprogramming induces a steady decline in epigenetic age before loss of somatic identity https://onlinelibrary.wiley.com/doi/full/10.1111/acel.12877 Induced pluripotent...

A new research on NMN! NMN fully reversed an age‐related deficiency in systolic function. https://onlinelibrary.wiley.com/doi/full/10.1111/acel.13213 The effects of two different mitochondrial‐targeted drugs, SS‐31 and NMN, were tested on Old mouse hearts. After treatment with the drugs, individuall...

https://www.medrxiv.org/content/10.1101/2020.08.06.20169854v1 "The genetic variation that leads to a longer lifespan is significantly associated with a lower risk of COVID-19 infection. The risk of been infected is decreased by 68% per additional 10 years of life." "At the phenotypic ...

Another piece of evidence on the effect of NMN to oocyte quality! https://doi.org/10.1016/j.celrep.2020.107987 Key points: - NMN supplementation restores NAD+ levels in maternally aged oocytes - NMN increases the number of ovulated oocytes in aged mice - NMN enhances meiotic competency and fertiliza...

This is an interesting study https://pubmed.ncbi.nlm.nih.gov/32718347/ They engineered Escherichia coli cells to biosynthesize the NMN, which has been efficiently used in cell-free biosynthesis. They explored various pathway combinations and host gene disruption to achieve an intracellular level of ...

Hello, I hope that you are all well. I’ve been doing some reading and went back to the original nmn mice article in cell. https://www.cell.com/cell/fulltext/S0092-8674(18)30152-1 “To restore NAD+ levels, we administered NMN to 18-month-old mice via drinking water for 2 months at 400 mg/kg/day” Plea...