NAD+ Forums

https://pubmed.ncbi.nlm.nih.gov/32467649/ This is a really good review paper that systemically reviewed known anti-aging drugs. In this review paper, the authors summarized recent efforts on identifying compounds with longevity properties. They then selected a few longevity compounds from animal stu...

This paper provides the mechanism of anti-cancer property of fisetin. https://pubmed.ncbi.nlm.nih.gov/32530958/ Fisetin was previously reported to induce the p53-mediated apoptotic pathway in human renal carcinoma cells [40]. Yet, the underlying mechanism and direct connection to SUMO1 has not been ...

Very low-carbohydrate, high-fat ketogenic diets (KDs) induce a pronounced shift in metabolic fuel utilization that elevates circulating ketone bodies; however, the consequences of these compounds for host-microbiome interactions remain unknown. Here, we show that KDs alter the human and mouse gut mi...

Hi jessicaP, welcome to the forum. There were some reports said long-term fasting is more difficult for female than male, probably due to sex difference. It would be interesting if NAD precursor plays a role in helping fasting, great to hear!

/quote] Actually, it makes a lot of sense. If you look at the expression level of Slc12a8 (the transport of NMN on the cell membrane) across different tissue, the pancreas is one of the top three organs with the highest expression level of l. https://i.postimg.cc/d7bqq5dJ/Screen-Shot-2020-06-04-at-...

/quote] Actually, it makes a lot of sense. If you look at the expression level of Slc12a8 (the transport of NMN on the cell membrane) across different tissue, the pancreas is one of the top three organs with the highest expression level of Slc12a8. https://i.postimg.cc/d7bqq5dJ/Screen-Shot-2020-06-...

A few years ago, my wife was diagnosed with type 2 diabetes. Although the article below is a bit dated, it explains very well how NAD+ boosters can actually reverse this terrible, life-threatening disease. Since her initial diagnoses, she began taking NMN, not steadily or in great quantity at first...

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Preprint published yesterday: Recent reports of metformin drug products contaminated with unacceptable levels of the probable human carcinogen N-Nitrosodimethylamine (NDMA) prompted a national sampling of post-market metformin drug products. To most broadly sample the market and minimize supply chai...

This study shows that the age-dependent degeneracy of the circadian timing system can be reversed in mice by pharmacologically increasing the intracellular pools of nicotinamide adenine dinucleotide (NAD+). https://www.sciencedirect.com/science/article/abs/pii/S1097276520302367?via%3Dihub Comment fr...