NRNicotinamide riboside is a potential therapeutic target for cardiac fibrosis.

Fred

Nicotinamide riboside is a potential therapeutic target for cardiac fibrosis.

Post by Fred »

Highlights

•TGF-β1 can induce EndMT and repress mitochondrial unfolded protein response in endothelial cells.

•NAD + repletion can ameliorate TGF-β1-induced EndMT through improving mitochondrial unfolded protein response in endothelial cells.

•Inhibition of prohibitin proteins (PHB and PHB2) inhibits the protective effect of nicotinamide riboside via repressing mitochondrial unfolded protein response in endothelial cells.

•Overexpression of prohibitin proteins can alleviate TGF-β1-induced EndMT by improving mitochondrial unfolded protein response in endothelial cells.


https://www.sciencedirect.com/science/a ... 22?sfns=mo


SeanYates
Posts: 6
Joined: Tue Aug 20, 2019 7:09 pm

Re: Nicotinamide riboside is a potential therapeutic target for cardiac fibrosis.

Post by SeanYates »

interesting for cardiac fibrosis patients..

:D
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