Glutathione precursors increase lifespan in mice by 24%
Posted: Thu Apr 07, 2022 9:47 pm
Scientists from Baylor College of Medicine in Houston studying glutathione precursors have demonstrated some of the best life extension results ever achieved in mice – increasing their lifespan by 24%.
Glutathione is the most abundant intracellular antioxidant and the backbone of natural defenses against reactive oxygen species, which are byproducts of normal oxygen metabolism that accumulate in the body with age and interfere with chemical processes.
Oxidative stress happens when the delicate balance between the production and degradation of reactive oxygen species is lost. This can be caused by various stressors, such as UV radiation, but also by aging.
Glutathione levels decline with age, so supplementing it could affect other processes of aging.
GlyNac – Glycine plus NAC
Regular Glutathione by itself has poor bioavailabilty, so researchers in this study used GlyNAC, a combination of two Glutathione precursors, glycine and N-acetylcysteine, or NAC). GlyNAC has already been an object of several studies.
The same group that is behind this new paper has previously shown that continuous GlyNAC supplementation in humans alleviates mitochondrial dysfunction and improves mitophagy, nutrient sensing, and genome stability. It also reverses premature aging in people with HIV.For this study, the researchers took the study back to mice because humans are so long-lived that it makes studying any intervention’s direct effect on lifespan extremely difficult.
The researchers ran two studies simultaneously, one dedicated solely to determining the effect of GlyNAC on lifespan and the second one on various other parameters. In the first study, 32 mice were equally divided between the study group and the control group. At the age of 65 weeks, which is mid-life by mouse standards, 8 males and 8 females started receiving GlyNAC with food. Supplementation continued until the mice died of age-related diseases.
Read the full article by clicking the link below:
https://renuebyscience.com/glutathione- ... ice-by-24/
Glutathione is the most abundant intracellular antioxidant and the backbone of natural defenses against reactive oxygen species, which are byproducts of normal oxygen metabolism that accumulate in the body with age and interfere with chemical processes.
Oxidative stress happens when the delicate balance between the production and degradation of reactive oxygen species is lost. This can be caused by various stressors, such as UV radiation, but also by aging.
Glutathione levels decline with age, so supplementing it could affect other processes of aging.
GlyNac – Glycine plus NAC
Regular Glutathione by itself has poor bioavailabilty, so researchers in this study used GlyNAC, a combination of two Glutathione precursors, glycine and N-acetylcysteine, or NAC). GlyNAC has already been an object of several studies.
The same group that is behind this new paper has previously shown that continuous GlyNAC supplementation in humans alleviates mitochondrial dysfunction and improves mitophagy, nutrient sensing, and genome stability. It also reverses premature aging in people with HIV.For this study, the researchers took the study back to mice because humans are so long-lived that it makes studying any intervention’s direct effect on lifespan extremely difficult.
The researchers ran two studies simultaneously, one dedicated solely to determining the effect of GlyNAC on lifespan and the second one on various other parameters. In the first study, 32 mice were equally divided between the study group and the control group. At the age of 65 weeks, which is mid-life by mouse standards, 8 males and 8 females started receiving GlyNAC with food. Supplementation continued until the mice died of age-related diseases.
Read the full article by clicking the link below:
https://renuebyscience.com/glutathione- ... ice-by-24/
