NAD+ Preservers ⇒ Resveratrol with NMN?

[Fred]

One of the side effects of metformin is B12 depletion.

Yes, this. Thank you DrDavid. I just wrote down the remedy but didn´t spell out the reason why the supplemental B12 is prudent when taking metformin.

[Pickleball101]

Dr. David Sinclair is matching a Gram a day of Resveratrol with a Gram of NMN. I've been taking the two for a year,
and found Dr. Martins 180 capsules of 1200 mg on Amazon the best that works for me. Ben, 78.

[Drdavid]

Does Dr. Sinclair offer any reason for the 1000mg of Resveratrol? Why is this the magic dose?

[NewLifeScience]

One of the side effects of metformin is B12 depletion. If you are taking this drug or its botanical derivative make sure you take B12 also.

Yes, thank you

[NewLifeScience]

Does Dr. Sinclair offer any reason for the 1000mg of Resveratrol? Why is this the magic dose?

Hmm he was at 500 mg per day in one interview i heard him on (unless i misheard him).

But i am going to guess that this is all new enough to be a best guess. if one weighs 200 pounds, it is hard to imagine 1 gram getting into all of your cells.

[Fred]

Does Dr. Sinclair offer any reason for the 1000mg of Resveratrol? Why is this the magic dose?

In his book he cites two reasons: low solubility in the gut (=low bioavailability) and low potency for SIRT1 activation. But exactly why it landed on 1000 mg I don´t know.

[Vandevalk1]

Can anyone please list the brand of Resveritrol they supplement with?

I am curious to find a reputable brand.

currently i am using Webber Naturals that I bought off Amazon. But it only contains 200mg of Japanese knotweed and 25mg of grape seed extract.

Thanks

[Drdavid]

Does Dr. Sinclair offer any reason for the 1000mg of Resveratrol? Why is this the magic dose?

In his book he cites two reasons: low solubility in the gut (=low bioavailability) and low potency for SIRT1 activation. But exactly why it landed on 1000 mg I don´t know.

Maybe the high dosage is to try to get the maximum bioavailability. This would be an interesting question to get to ask.

[edjee]

I'm reading to supplement B12 when taking Metformin. Is this the case when taking Resveratrol as well?

[Vandevalk1]

I'm reading to supplement B12 when taking Metformin. Is this the case when taking Resveratrol as well?

I have not read anything to say you should supplement with B12 while taking resveratrol.