The link below is to a presentation on YouTube by Dr. David Sinclair, of why he moved from taking Metformin for 30 years . to Berberine, and his own research before doing so. He likes to equalize his intake of supplements, so you'll find that is true with NMN, TMG and Bereberine, taken WITH food for their low solubility in oral powder intake.
I have been following his suggestions, and after carrying a "Panzer" (Spanish for tummy) for 40 years, was amazed to see it disappear, with the loss of 15 more lbs, in about a months time. My belt loops tightened up two holes, and I can see my toes!. One Caution, if you're on an Ace Inhibitor blood thinner, wean yourself off of , as you wean your self onto Berberine. My Blood pressure dropped 30 points from 157 to 127/70, Theses benefits ALL come from the ability of Berberine to lower your Glucose levels, controlling your insulin tolerance. That allows More Good nutrition into the calls, with NMN for the anti-aging effects you desire. They are a natural combo. Another pathway , is Ca AKG. Research the many Blind Study trials for your age group for results.
Ben Y. , 81+ Pickleball 101 4 years RbS.
Nope, was never really taking it regularly. Only when a "bad meal" was unavoidable, so tasty stuff but not good for you so to speak I would take one to even out the glucose spikes. It did though impact my own gut bacteria so slight discomfort and then to put it bluntly then diarrhea!jamierh wrote: ↑Wed Sep 14, 2022 2:46 pmAre you still taking Metformin? What effects were you feeling on your gut?
Then trying the same thing with Berberine, did not have the same impact on gut but still did its job to lowering glucose spike, so Berberine all the way for me now.
Some interesting things noted when tracking myself for 4 weeks with a Glucose monitor:
Things that drop Glucose:
Taking 2 x RBS LIPO Activator capsules (So Fisetin, Quercetin and Spermidine)
Broccoli Sprout powder
Obviously Berberine and Metformin as well
Noting that I did take a Berberine thinking that I am about to eat a bunch of potato chips and a few beers would give me a spike, 2 hours later before just before dinner I ended up with a low Glucose (2.8 mmol/l) and felt very ordinary. So the lesson is learnt, that is I will only take just before or with 'bad meals".
Things that increase glucose:
Interestingly a black coffee while fasting and then kicking off some exercise lifts it a little, then it gradually reduces and levels out.
Of course the usual's being Pasta, Brown (not as bad) and White Rice, Cous Cous and with the biggest spike came from a can of Blackberry Cider (very tasty and sweet!).
I am taking so many plant based molecules already I think I have it covered for now on the cancer and Alzheimers front. Cause my Glucose is already in check and some supplements (like RBS LIPO Activator) can drop it further it risks a glucose drop. Not going to take metformin every day, unless of course this changes.drkris69 wrote: ↑Mon Sep 19, 2022 4:46 amYeah Im digging the Berberine as well. Ive lost about 5 lbs in 19 days along with I lost 2" in the waist and more 6 pack abs are showing again at the age of 53. I don't know if I will stay on Berberine as I might go back to taking Metformin. Reason being, Metformin is considered a "essential medication" in the Longevity world and proven that people who Metformin will live longer and be protected from Alzheimers disease and certain cancers as according to Dr. Sinclair. I dont think Berberine protects the body against these diseases.
Based on the science it is not one thing that will trigger or protect against degenerative brain diseases like Alzheimers. Check out the precision approach from Dr Dale Bredesen, I have been looking into his approach over the last week (seen a few of his presentation's, etc), I am going to do their free cognitive test just got to find the best / clear 10-15min to ace the test