Healthy Aging News and ResearchDr. Ocampo: predictions on the aging field for the next 10 years

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AlbertY
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Location: Boston, MA

Dr. Ocampo: predictions on the aging field for the next 10 years

Post by AlbertY »

1. TAME trial: metformin will not be the best anti-aging drug but will pave the regulatory way for future anti-aging trials with "real" anti-aging endpoints
2. Dog Aging Project: this clinical trial will demonstrate significant effects of rapamycin on lifespan and the onset of age-related diseases in a species very close and very relevant to humans.
3. Senolytics: this field will explode in the next decade with not only significant effects of this class of drugs on multiple age-associated diseases such as OA and cancer but also new and better ways to target senescent cells based on more knowledge of their biology.
4. NAD-related compounds (NR and NMR) and sirtuin-activating compounds (STACs): these compounds will show modest effects on human trials but they will be extensively used as supplements.
5. We will see the development of novel and stronger ways to slow-down and/or reverse aging based on other approaches such as cellular reprogramming, parabiosis/young plasma or other biological strategies that we cannot even imagine at this moment.
6. CRISPR/Cas9 and AAV will not play a significant role in the development of anti-aging therapies due to the low contribution of genetics to aging and the high efficacy/low-risk ratio that will be required for the implementation of long-term preventive anti-aging therapies.
7. Political, economic and social changes on many systems including health, retirement, and education will start to occur as global demographics continue to change. The global warming of humanity will hit the world and it will not be possible to avoid it or ignore it anymore.


Ph.D. student at Harvard Medical School, doing research on aging
rhett
Posts: 205
Joined: Wed Sep 18, 2019 1:39 pm

Re: Dr. Ocampo: predictions on the aging field for the next 10 years

Post by rhett »

Curious about #6... seems like there may be a role for inserting Yamanaka factor genes into cells so they can reverse epigenetic aging. At least that’s one of the things Dr Sinclair’s lab is working on.
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