Healthy Aging News and ResearchFisetin Protects Against Cardiac Cell Death

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AlbertY
Posts: 175
Joined: Mon Aug 12, 2019 4:01 pm
Location: Boston, MA

Fisetin Protects Against Cardiac Cell Death

Post by AlbertY »

Here, we mined the data and performed a deep in silico analysis to identify drugs highly likely to induce cardiac regeneration. Fisetin was identified as the top candidate. We validated its effects in an in vitro model of MI/IRI in mammalian cardiac cells. Fisetin enhances viability of rat cardiomyocytes following hypoxia/starvation - reoxygenation. It inhibits apoptosis, decreases ROS generation and caspase activation and protects from DNA damage. Interestingly, fisetin also activates genes involved in cell proliferation. Fisetin is thus a highly promising candidate drug with clinical potential to protect from ischemic damage following MI and to overcome IRI.
https://pubmed.ncbi.nlm.nih.gov/3207607 ... -activity/


Ph.D. student at Harvard Medical School, doing research on aging
rhett
Posts: 205
Joined: Wed Sep 18, 2019 1:39 pm

Re: Fisetin Protects Against Cardiac Cell Death

Post by rhett »

Good to see our buddy fisetin having other positive effects beyond clearing senescent cells.

Am I reading this correctly that they’re looking at the effect of fisetin immediately after ischemic event and in the following? It’s preventing damage rather than reversing it?
drkris69
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Joined: Tue Aug 20, 2019 2:41 pm

Re: Fisetin Protects Against Cardiac Cell Death

Post by drkris69 »

Thanks for the post AlbertY. Very interesting indeed.
Newage
Posts: 1808
Joined: Thu Aug 22, 2019 10:22 pm

Re: Fisetin Protects Against Cardiac Cell Death

Post by Newage »

drkris69 wrote: Mon Feb 24, 2020 3:14 pm Thanks for the post AlbertY. Very interesting indeed.
Can’t wait for the lipo product to be made available from ABN..
canadahealthy
Posts: 541
Joined: Tue Aug 20, 2019 5:31 pm

Re: Fisetin Protects Against Cardiac Cell Death

Post by canadahealthy »

I guess this is better as a preventative but it can also regenerate.

This is the strongest Senolytic, yes?
CeeJayBee
Posts: 243
Joined: Thu Aug 22, 2019 4:19 pm

Re: Fisetin Protects Against Cardiac Cell Death

Post by CeeJayBee »

canadahealthy wrote: Mon Feb 24, 2020 6:17 pm I guess this is better as a preventative but it can also regenerate.

This is the strongest Senolytic, yes?
I think it's very high up on the list, canadahealthy i give it to my mom (NAD+ booster) along with Blue Berry extract, which is a major source of Fisetin.
jessicaP
Posts: 214
Joined: Sun Nov 03, 2019 10:52 am

Re: Fisetin Protects Against Cardiac Cell Death

Post by jessicaP »

I think it is one of the strongest. Eventually the results of the trials on elderly frailty will be out.

They do High doses 2 days followed by 28 days no fisetin.

Not sure how that will compare to daily fisetin.
rhett
Posts: 205
Joined: Wed Sep 18, 2019 1:39 pm

Re: Fisetin Protects Against Cardiac Cell Death

Post by rhett »

Very interested to see those results. I’ve done the 2 day high dose protocol 3 times now. No obvious effects but I wouldn’t expect to see much as I’m on the “younger” (relatively speaking) end of things.
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