Healthy Aging News and Research ⇒ Young blood plasma fraction reverse the epigenetic age of rats by 54%
Young blood plasma fraction reverse the epigenetic age of rats by 54%
https://www.biorxiv.org/content/10.1101 ... 7.082917v1
This is a shocking result. If it holds true, it would be the most powerful intervention we ever have seen.
Plasma fraction treatment consists of two series of IV injections, four times on alternate days for 8 days. A 2nd series of injections were given 95 days later. The epigenetic clocks reversal was: liver 75%, blood 66%, heart 57%, hypothalamus 19%. Average rejuvenation across four tissues was 54.2%.
The plasma fraction is from Nugenics, a commercial company, and they didn't reveal the exact content of the "plasma fraction" they used.
David Sinclair's twitter thread: https://twitter.com/davidasinclair/stat ... 8695857152
This is a shocking result. If it holds true, it would be the most powerful intervention we ever have seen.
Plasma fraction treatment consists of two series of IV injections, four times on alternate days for 8 days. A 2nd series of injections were given 95 days later. The epigenetic clocks reversal was: liver 75%, blood 66%, heart 57%, hypothalamus 19%. Average rejuvenation across four tissues was 54.2%.
The plasma fraction is from Nugenics, a commercial company, and they didn't reveal the exact content of the "plasma fraction" they used.
David Sinclair's twitter thread: https://twitter.com/davidasinclair/stat ... 8695857152
Ph.D. student at Harvard Medical School, doing research on aging
Re: Young blood plasma fraction reverse the epigenetic age of rats by 54%
Of course, this all hinges on the accuracy of Horvath's custom epigenetic clock. Also the FDA has stated that plasma from young people offers “no proven clinical benefit” as a treatment against aging or Alzheimer’s disease.AlbertY wrote: ↑Sun May 24, 2020 2:42 pm https://www.biorxiv.org/content/10.1101 ... 7.082917v1
This is a shocking result. If it holds true, it would be the most powerful intervention we ever have seen.
Plasma fraction treatment consists of two series of IV injections, four times on alternate days for 8 days. A 2nd series of injections were given 95 days later. The epigenetic clocks reversal was: liver 75%, blood 66%, heart 57%, hypothalamus 19%. Average rejuvenation across four tissues was 54.2%.
The plasma fraction is from Nugenics, a commercial company, and they didn't reveal the exact content of the "plasma fraction" they used.
David Sinclair's twitter thread: https://twitter.com/davidasinclair/stat ... 8695857152
https://www.scientificamerican.com/arti ... nsfusions/
Re: Young blood plasma fraction reverse the epigenetic age of rats by 54%
It is exciting to know that science is exploring these different types treatments to reverse aging. I think we are very close to having a viable treatment available to the public for those interested in becoming younger and healthier.
Re: Young blood plasma fraction reverse the epigenetic age of rats by 54%
It is probably going to benefit any older mammal to get complete blood transfusion from a younger source.
Re: Young blood plasma fraction reverse the epigenetic age of rats by 54%
Yeah... It is really too good to be true... The paper hasn't gone through peer review yet, so we will see.jocko6889 wrote: ↑Tue May 26, 2020 2:53 amOf course, this all hinges on the accuracy of Horvath's custom epigenetic clock. Also the FDA has stated that plasma from young people offers “no proven clinical benefit” as a treatment against aging or Alzheimer’s disease.AlbertY wrote: ↑Sun May 24, 2020 2:42 pm https://www.biorxiv.org/content/10.1101 ... 7.082917v1
This is a shocking result. If it holds true, it would be the most powerful intervention we ever have seen.
Plasma fraction treatment consists of two series of IV injections, four times on alternate days for 8 days. A 2nd series of injections were given 95 days later. The epigenetic clocks reversal was: liver 75%, blood 66%, heart 57%, hypothalamus 19%. Average rejuvenation across four tissues was 54.2%.
The plasma fraction is from Nugenics, a commercial company, and they didn't reveal the exact content of the "plasma fraction" they used.
David Sinclair's twitter thread: https://twitter.com/davidasinclair/stat ... 8695857152
https://www.scientificamerican.com/arti ... nsfusions/
Ph.D. student at Harvard Medical School, doing research on aging
Re: Young blood plasma fraction reverse the epigenetic age of rats by 54%
If it ever does, this would be a game changer!
Re: Young blood plasma fraction reverse the epigenetic age of rats by 54%
Here is the comment on the paper above.
https://blogs.sciencemag.org/pipeline/a ... ent-321890
"Overall, I still find such results hard to believe, but at the same time they seem to be showing up from multiple experiments. "
https://blogs.sciencemag.org/pipeline/a ... ent-321890
"Overall, I still find such results hard to believe, but at the same time they seem to be showing up from multiple experiments. "
Ph.D. student at Harvard Medical School, doing research on aging
Re: Young blood plasma fraction reverse the epigenetic age of rats by 54%
It seems that they are saying any results would only be short lived at best.
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Re: Young blood plasma fraction reverse the epigenetic age of rats by 54%
This type of therapy is indeed radical but the results would be dramatic.
K am wondering if they will soon be able to multiply a small amount of plasma in the same way they can multiple DNA using PCR (polymerase chain reaction).
That way it would not depend on a heavy donor supply.
PCR is extremely accurate. It can make exact duplicates of large strands of dna.
This would be a trillion dollar technilogy if it ever emerged.
K am wondering if they will soon be able to multiply a small amount of plasma in the same way they can multiple DNA using PCR (polymerase chain reaction).
That way it would not depend on a heavy donor supply.
PCR is extremely accurate. It can make exact duplicates of large strands of dna.
This would be a trillion dollar technilogy if it ever emerged.