NMN ⇒ Any mood changes while taking NMN?

[Vandevalk1]

Are you allowed to recommend a drug that has no published studies in human yet?

[Drdavid]

NMN typically improves moods and focus.

Curious if you recommend it to patients who have mild anxiety?

I have not. However, I have told patients that have anxiety that they should take NAD/NMN to possibly improve mitochondrial function.

[daviddean]

Its interesting the correlation between mithocondrial disorders and psychiatric illness, included anxiety and depression.
I do some quotes from 2 interesting studies:

There is evidence that people with known mitochondrial disorders suffer psychiatric illness at rates higher than the general population.
A mitochondrial bioenergetic basis of depression
N. Jennifer Klinedinst & William T. Regenold
Link: https://www.ncbi.nlm.nih.gov/pubmed/25262287

Here is another intesting study, more specific the depression and mitochondrial disorders.
Brain is highly active organ with high energy consumption and organs with highest energy demand are more susceptible to the deleterious effect of reduced energy production. Mainly neurons obtain energy from mitochondrial OXPHOS. Neuron obtains energy through glycolysis but brain is unable to store glycogen so constant supply of glucose is needed. When oxidative phosphorylation is compromised, neurons are unable to meet their energy demand and alteration in their various physiological functions occurs due to reduced ATP production. Studies have shown that chronic mild stress inhibits mitochondrial OXPHOS, dissipates mitochondrial membrane potential and damages mitochondrial ultrastructure in various brain regions including hippocampus, cortex and hypothalamus of mice [77, 78]. These observations lead to the conclusion that most probably depression is caused by energy impairment in the brain due to mitochondrial dysfunction [79, 80].

Mitochondrial Dysfunction in Depression
Yashika Bansal and Anurag Kuhad
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981740/


In my personal experience, using Alybe by Nature NMN sublingual, I assume 8 tablets daily and I can affirm a mood more stable, no more depression symptoms, rare anxiety and, above all, an improved mental and physical energy. I'm 50 now and for me it works well.
David

[Newage]

Thank you for the links and your brief story David.
Your input is always appreciated.

[Drdavid]

Its interesting the correlation between mithocondrial disorders and psychiatric illness, included anxiety and depression.
I do some quotes from 2 interesting studies:

There is evidence that people with known mitochondrial disorders suffer psychiatric illness at rates higher than the general population.
A mitochondrial bioenergetic basis of depression
N. Jennifer Klinedinst & William T. Regenold
Link: https://www.ncbi.nlm.nih.gov/pubmed/25262287

Here is another intesting study, more specific the depression and mitochondrial disorders.
Brain is highly active organ with high energy consumption and organs with highest energy demand are more susceptible to the deleterious effect of reduced energy production. Mainly neurons obtain energy from mitochondrial OXPHOS. Neuron obtains energy through glycolysis but brain is unable to store glycogen so constant supply of glucose is needed. When oxidative phosphorylation is compromised, neurons are unable to meet their energy demand and alteration in their various physiological functions occurs due to reduced ATP production. Studies have shown that chronic mild stress inhibits mitochondrial OXPHOS, dissipates mitochondrial membrane potential and damages mitochondrial ultrastructure in various brain regions including hippocampus, cortex and hypothalamus of mice [77, 78]. These observations lead to the conclusion that most probably depression is caused by energy impairment in the brain due to mitochondrial dysfunction [79, 80].

Mitochondrial Dysfunction in Depression
Yashika Bansal and Anurag Kuhad
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981740/


In my personal experience, using Alybe by Nature NMN sublingual, I assume 8 tablets daily and I can affirm a mood more stable, no more depression symptoms, rare anxiety and, above all, an improved mental and physical energy. I'm 50 now and for me it works well.
David

David,
I had read the first article but not the second. Thank you for sharing this with the community. I agree that we can see psychiatric applications for NMN/NAD products. I fear that many of those that are speaking about NAD/NMN currently are hoping to patent a molecule for pharmaceutical purposes and financial gain. NAD/NMN is a product that could be used for millions of people and it is inexpensive.
Thank you again for the research. I always enjoy your posts.

[rachwozere]

Yes, again... Could be coincidence but I am experiencing unexplained anxiety which is quite a physical thing as oppose to it feeling psychological. 
It may be the NMN or resveratrol? 
I was taking 1g of NMN but I think, from today, I'm going to reduce to 500mg. I'm only 120 pounds and 46 so I think the dosage may have been too high? 

[jocko6889]

Yes, again... Could be coincidence but I am experiencing unexplained anxiety which is quite a physical thing as oppose to it feeling psychological. 
It may be the NMN or resveratrol? 
I was taking 1g of NMN but I think, from today, I'm going to reduce to 500mg. I'm only 120 pounds and 46 so I think the dosage may have been too high? 

 

Hi, the symptoms could be related to low methyl pools.  Used up NAD+ takes the form of nicotinamide (NAD) which if you get too much is attached to a a methyl group and excreted out the urine.  Methyl groups are needed to make creatine for muscle and dopamine for the brain, so if you're low you could experience depression, possibly anxiety.  Take an equal amount of TMG in milligrams with your NMN and this should help.

 

[drkris69]

Jocko you nailed it, low methyl groups. TMG is a great place to start.