NMNLiposomal NMN Safety

greenjoy
Posts: 2
Joined: Tue May 10, 2022 4:54 pm

Liposomal NMN Safety

Post by greenjoy » Tue May 10, 2022 6:13 pm

Hi All,

In this Renue by Science video on Youtube (https://www.youtube.com/watch?v=-3RSi25g4LY), a comment (quoted below) raises the question about the safety of Liposomal NMN, and whether it has been tested on animals. The response from Renue By Science mentions a human study that has been done in Melbourne, but that the results are not yet out. Is there any update on this, considering that the response is from 8 months ago? Thanks!

User comment by Paulf Wolf: "Liposomal formulations of NMN make me nervous because cells have a way to control the amount of NMN inside. It gets converted to NR and then back into NMN if needed, but NMN doesn't seem to be able to go through the cell wall. The liposomes go through the cell walls with no controls at all. The normal way to get drugs to penetrate through tissues, such as the skin, is by using surfactants which open the pores. Then the drug goes through the pores, or around the cells, instead of going into them and then, supposedly, coming out the other side. The science behind this is not good. How can the cells repackage the NMN into new vesicles so it comes out from the opposite side? Have any of these liposomal formulations ever been tested on animals?"

Renue By Science response: "Renue has been tested on humans, but the extreme lockdown in Melbourne has held up publishing the results for 18 months now."


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jocko6889
Posts: 551
Joined: Tue Jul 23, 2019 11:35 pm
Location: Tulsa, OK

Re: Liposomal NMN Safety

Post by jocko6889 » Wed May 11, 2022 6:29 pm

greenjoy wrote:
Tue May 10, 2022 6:13 pm
Hi All,

In this Renue by Science video on Youtube (https://www.youtube.com/watch?v=-3RSi25g4LY), a comment (quoted below) raises the question about the safety of Liposomal NMN, and whether it has been tested on animals. The response from Renue By Science mentions a human study that has been done in Melbourne, but that the results are not yet out. Is there any update on this, considering that the response is from 8 months ago? Thanks!

User comment by Paulf Wolf: "Liposomal formulations of NMN make me nervous because cells have a way to control the amount of NMN inside. It gets converted to NR and then back into NMN if needed, but NMN doesn't seem to be able to go through the cell wall. The liposomes go through the cell walls with no controls at all. The normal way to get drugs to penetrate through tissues, such as the skin, is by using surfactants which open the pores. Then the drug goes through the pores, or around the cells, instead of going into them and then, supposedly, coming out the other side. The science behind this is not good. How can the cells repackage the NMN into new vesicles so it comes out from the opposite side? Have any of these liposomal formulations ever been tested on animals?"

Renue By Science response: "Renue has been tested on humans, but the extreme lockdown in Melbourne has held up publishing the results for 18 months now."


 
There are several errors in the comment you quote above.  First, "NMN doesn't seem to be able to go through the cell wall" isn't correct.  It really depends on the type of cell.  In the gut, NMN is readily taken into cells via an escort enzyme called slc12a8.  Secondly, liposomes don't go through cell walls with no controls.  The liposomes simply get the molecules inside past the GI tract where much of it typically gets broken down so that it can get to the tissues intact.  Then from outside the cell wall, the NMN is either converted to NR or gets escorted inside.

The science behind liposomal delivery is well established and there are no safety concerns.  We do testing to ensure greater bioavailability of Lipo NMN over the powdered form and to be able to establish how much more bioavailable it is, but there is no concern on safety.  You can of course consume too much of any supplement, so we recommend not more than 1.5grams of NMN per day of the powder and probably no more than 500mg of the liposomal NMN.
 
drkris69
Posts: 1188
Joined: Tue Aug 20, 2019 2:41 pm

Re: Liposomal NMN Safety

Post by drkris69 » Sat May 14, 2022 9:23 am

Thanks Jocko, great advise..
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