NMN ⇒ MTHFR Mutation & Success with NMN

[mydarlingesme]

I would love to hear from people who are successfully using NMN with the MTHFR mutation. How did you scale up? Where are you at dosage-wise? What else are you taking? Are you getting good results from NMN? Any other thoughts, traps, tips? THANK YOU!

[michaeljkelly]

Wow, I had never heard of this mutation, but i can think of a couple candidates.

I imagine there is a test?

[canadahealthy]

If you are in Canada, there is a fairly reasonably priced test,

https://empowerdxlab.com/products/produ ... s6EALw_wcB

I imagine there is a cheaper version for US residents.

[NewLifeScience]

I would love to hear from people who are successfully using NMN with the MTHFR mutation. How did you scale up? Where are you at dosage-wise? What else are you taking? Are you getting good results from NMN? Any other thoughts, traps, tips? THANK YOU!

 

Hi 
So is this something you are living with?
Do you know how prevalent it is?

[canadahealthy]

I wonder how many people have this mutation without being aware.

These are very common symptoms unfortunately.

[JanCOhio]

I got curious about this MTHFR mutation, since some websites attributed it to common, yet serious problems.

Now, I am not trying to delegitimize anyone who may have it, as some variants can be very serious. But a PHD of epidemiology at Kent State discusses the prevalence and possibly how the idea of a mutation gives alternative health website the reason to sell supplements that may not be necessary.

Anyway, here is the article.

 https://www.self.com/story/mthfr-geneti ... -explained

[Boxcost]

I got curious about this MTHFR mutation, since some websites attributed it to common, yet serious problems.

Now, I am not trying to delegitimize anyone who may have it, as some variants can be very serious. But a PHD of epidemiology at Kent State discusses the prevalence and possibly how the idea of a mutation gives alternative health website the reason to sell supplements that may not be necessary.

Anyway, here is the article.

 https://www.self.com/story/mthfr-geneti ... -explained



 

This is a good take as well:
https://blog.23andme.com/health-traits/ ... thfr-gene/

Both article's above make the same statement: "Some very rare variants in MTHFR can cause a severe condition called homocystinuria, which affects fewer than 1 in 200,000 people in most ethnicities."

There are not to many options for genetic health information as this is still not a mature business and I believe for Australia would require TGA approval etc, each country is different. I found at the time https://www.promethease.com/ (Less curation of other data i.e. studies and recommendations but a lot more coverage of different genes) and https://www.foundmyfitness.com/genetics  that curated open sourced data from https://www.snpedia.com/ and published studies to deliver some interesting genetic health insights. The options for me at the time for testing were 23andMe and Ancestry, I ended up with 23andme.com or https://www.23andme.com/en-int/ which one of the sites tests more with but if you have already done https://www.ancestry.com.au/anstry you should be able to just download your DNA file and upload it to these sites.

As a result of the testing I have been inspired to tweak my diet and supplements to mitigate against any notable issues to support healthy aging.

I have a partial MTHFR risk as an example that inspired me to add in equivalent TMG to my NMN as an insurance policy.  Turns out my Dad when we ran his through the sites has the "two variant alleles of the rs1801133(T;T) polymorphism" which from the report has "approximately 30% MTHFR enzyme activity as compared to normal levels" and "This diminished enzyme activity 'may' result in elevated homocysteine levels associated with a variety of diseases" so he has a higher risk of being in the 1 in 200,000 risk category! 

Our good or bad genes are activated by lifestyle and environment, so view these genetic insights (at this stage of the science) as helpful. Highlighting more like a "tenancy towards" or risk factors that we can do things or be mindful about.
 
 

[Slodok]

I would love to hear from people who are successfully using NMN with the MTHFR mutation. How did you scale up? Where are you at dosage-wise? What else are you taking? Are you getting good results from NMN? Any other thoughts, traps, tips? THANK YOU!

 

When you get vitamin B9 from food  has to be metylated to be used by body. Same with vitamin B12. When you have mutation in MTHFR genotype B9 can't be used. When you have mutation in MTRR genotype B12 can't be used.Aditionally you can have AMPD1 mutation and double lactose alergy mutations. All these nmn + diets +healthy living don't count that there are mutants which don't do methylation, can't process sugars and has meat eating metabolism which survive on proteins and fats. These are from cro magnons + maybe neandertals mutations.I think science on aging has some issues with human spectrum. 

[pparker]

Hi, I guess this is a little late but I Just joined.  I have MTHFR;  to be precise I have a single copy of C677T IIRC.  I found this out from 23andme testing.

W.r.t., NMN, I started with 500 mg of NMN in lozenge for a few weeks ago (paired with resveratrol in a smaller quantity) and after a day or two moved up to 1000 mg.  For the most part it seems to have significant good effects on me;  it helped significantly with some neck/back problems I have.  After many years of problems and NSAID's I can identify when something helps with those very quickly;  NMN helped within minutes.

I am pretty sure that taking NMN means I'm running my body out of certain nutrients faster;  most obviously electrolytes (currently I'm supplementing those twice a day) and also B vitamins (B1 as benfotiamine, and also general B-complex).  Based on my prior experience I expect that this running me out of these things is indicative of healing (some MTHFR people refer to "refeeding syndrome", see discussion on Phoenix Rising).

However, I am doubting the safety and utility of NMN paired with resveratrol, particularly given Charles Bremmer's talk today.  I will consult my doctors.

I am not sure that there is much relationship between MTHFR and NMN.  MTHFR is about the methylation cycle, which is very important for many things.  NMN is about NAD and mitochondrial function, which is very important for many things.  But as far as overlap, I don't know of anything specific.  Here are a couple links I Just found that may be relevant:
* https://www.thorne.com/take-5-daily/art ... e-riboside
* viewtopic.php?t=1228

Note:  I am an outlier in that I respond rapidly and strongly to many supplements.  Presumably this is a combination of poor gut absorption and being bad enough off that there are lots of things that are limiting factors for me.  In particular, I responded very strongly and positively to methyl folate and methyl B12 initially, then had problems after a few weeks and had to discontinue.  Recently I discovered glycine, which is a common deficiency IIUC, and is used to buffer excess methyl groups, and now I can take as much or as little methylation stuff as I want.

Paul