NMN ⇒ Adrenal Glands and NMN

[Barlick]

First post so hoping for a good outcome of a tricky situation.

In 1977 I had 1¾ adrenalectomy to stop the surge of the hormone ALDOSTERONE. An MRI scan in 2017 revealed they have regenerated over time. For the last 12 months blood pressure meds have been increased substantially due to excess amounts of aldosterone production. I had also been taking NMN alongside Resveratrol, Quercetin, and a Sirt6 Activator. Is it possible that NMN might have caused the adrenals to up production in general. I hope not as I wish to continue NMN. Any advice greatly appreciated.
 

[jocko6889]

First post so hoping for a good outcome of a tricky situation.

In 1977 I had 1¾ adrenalectomy to stop the surge of the hormone ALDOSTERONE. An MRI scan in 2017 revealed they have regenerated over time. For the last 12 months blood pressure meds have been increased substantially due to excess amounts of aldosterone production. I had also been taking NMN alongside Resveratrol, Quercetin, and a Sirt6 Activator. Is it possible that NMN might have caused the adrenals to up production in general. I hope not as I wish to continue NMN. Any advice greatly appreciated.
 

 

NAD+ is needed for cellular energy and energy is needed for every physiological function in your body.  NAD+ is one of the most abundant molecules in your body, however we produce less and less of it as we age.  So even though supplementing with an NAD+ booster like NMN to produce more youthful levels of NAD+ is great for most people, this may or may not be true with someone who has a unique medical condition such as yours. 

I didn't see any specific studies when I googled "NAD+ adrenal glands" or something similar, however you know more about your condition and would be better at finding specific keywords for a google search to see if there is any available data or study in your particular case (hint: use NAD+ in your search, not NMN as NMN is just a precursor to NAD+).  I'm not sure an endocrinologist would be of much help either unless they were up on the latest anti-aging research.  

One obvious way to find out would be to stop taking any NAD+ boosters and see if this has an affect on your blood pressure or other factors you would measure in your blood by doing a blood test.

Something to also keep in mind is that even if NAD+ raises levels of a hormone like Aldosterone in your blood, a process known as homeostasis could kick in to lower it back down to normal levels again. If so, it would allow you to maintain proper levels of aldosterone while still achieving the other anti-aging benefits of NAD+.  Sorry I couldn't be of more help but hopefully this will point you in the right direction in your search.
 

[Newage]

Good advice from Jocko.
I searched  “high and low” to find a Medical Physician that practiced with Anti-aging and Longevity at the forefront in their way of thinking. I was lucky enough to find a Physician that practiced in that area that was also right up to speed with HRT (Hormone Replacement Therapy) or the restriction of. They are few and far between as most Doctors look at you like you have “Two Heads” as soon as you mention Anti-aging or Longevity. Although a minority, they are out there and hopefully you will find one to guide you on your longevity quest..
 

[Barlick]

Hi,

Thanks for that.

Absolutely correct on trying to take this to medical professionals. Totally out of their depth. The thing is, the collection of supplements I really want to continue taking will hopefully help mitigate against the after-effects of a life-time of resistant hypertension especially in the cardiovascular system by improving endothelial dysfunction, and also improve key aspects of kidney function. When taking NMN and the rest, I do feel 'healthier' and at 69 years old still paly tennis at a relatively high level, so not all doom and gloom.

I see a London-based top UK specialist for the first time in 45 years early December so mulling over whether to spill the longevity / healthspan protocols I have been on. In truth, the increased requirement of drugs to keep check on the affects of too much aldosterone has steadily been increased during the 45 years as the adrenal glands have continued to regenerate. I remain optomistic that I will be able to continue with my chosen supplements.

[drkris69]

I have a good one that I have to travel to see but worth it. He is on our level and thinks out side the box when it comes to just straight traditional medicine. Rick Cavender M.D. Columbus OH.

[Barlick]

Back on my DoNotAge supplement stack NMN, Resveratrol, TMG, Berberine, Quercetin, Sirt6 Activator, and Berberine. I have dropped Hyaluronic Acid, which worked well to ease my degenerative lower disc vertebrate whilst playing tennis, it did not help with kindney function as mine dropped very noticably. Just hope it bounced back.

Hyaluronan is a double-edged sword for kidney disease!!!
https://pubmed.ncbi.nlm.nih.gov/34009465/

 

[Boxcost]

Back on my DoNotAge supplement stack NMN, Resveratrol, TMG, Berberine, Quercetin, Sirt6 Activator, and Berberine. I have dropped Hyaluronic Acid, which worked well to ease my degenerative lower disc vertebrate whilst playing tennis, it did not help with kindney function as mine dropped very noticably. Just hope it bounced back.

Hyaluronan is a double-edged sword for kidney disease!!!
https://pubmed.ncbi.nlm.nih.gov/34009465/

 

 

Interesting, from the study "HMW-HA lends itself to protective effects, whereas LMW-HA promotes the deleterious characteristics of each disease"

They also found that LMW-HA (Low Molecular Weight) was pro-inflammation, where "high molecular weight-HA (HMW-HA) variants can exert anti-inflammatory and anti-fibrotic effects".

So the ABS HMW-HA LIPO is the one we want, and what I am on now!

Direct link to study:
https://link.springer.com/article/10.10 ... 21-05113-9
 

[Barlick]

Missed the difference between low and high molecular weight.Thanks.

[Newage]

Missed the difference between low and high molecular weight.Thanks.

 

Yes, not all supplement brands have the same ingredients in them. That’s why whenever I can I stick with AliveByScience products. That way It takes a lot of the guess work out of it..