A great new write-up and overview of autophagy and how it is related to sirtuins, mTOR, AMPK, fasting and especially exercise.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6742954/
Maximizing Longevity and Healthspan: Multiple Approaches All Converging on Autophagy
Abstract
Our understanding of the molecular basis of aging has greatly increased over the past few decades. In this review, we provide an overview of the key signaling pathways associated with aging, and whose modulation has been shown to extend lifespan in a range of model organisms.
We also describe how these pathways converge onto autophagy, a catabolic process that functions to recycle dysfunctional cellular material and maintains energy homeostasis.
Finally, we consider various approaches of therapeutically modulating these longevity pathways, highlighting exercise as a potent geroprotector.
Longevity ⇒ Autophagy and how it is related to sirtuins, mTOR, AMPK, fasting and especially to exercise.
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Re: Autophagy and how it is related to sirtuins, mTOR, AMPK, fasting and especially to exercise.
So how could one best summarize in layman's terms what autophagy is?Fred wrote: ↑Thu Oct 03, 2019 1:55 pm A great new write-up and overview of autophagy and how it is related to sirtuins, mTOR, AMPK, fasting and especially exercise.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6742954/
Maximizing Longevity and Healthspan: Multiple Approaches All Converging on Autophagy
Abstract
Our understanding of the molecular basis of aging has greatly increased over the past few decades. In this review, we provide an overview of the key signaling pathways associated with aging, and whose modulation has been shown to extend lifespan in a range of model organisms.
We also describe how these pathways converge onto autophagy, a catabolic process that functions to recycle dysfunctional cellular material and maintains energy homeostasis.
Finally, we consider various approaches of therapeutically modulating these longevity pathways, highlighting exercise as a potent geroprotector.
recycling poor/older cellular material into new, better quality cells?
Re: Autophagy and how it is related to sirtuins, mTOR, AMPK, fasting and especially to exercise.
Yes. I think autophagy (self-eating) is described pretty good in the abstract:
"...a catabolic process that functions to recycle dysfunctional cellular material and maintains energy homeostasis."
"...a catabolic process that functions to recycle dysfunctional cellular material and maintains energy homeostasis."
Re: Autophagy and how it is related to sirtuins, mTOR, AMPK, fasting and especially to exercise.
I've always found this to be extremely interesting, hence the reason i got started in IF in the first place. Switching to one meal a day is hard but not impossible, I find I get brain fog if i don't get that "second meal". Also i'm interested in gaining muscle mass, so the 2 meal balance seems to help me attain both goals.
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- Joined: Thu Aug 22, 2019 4:17 pm
Re: Autophagy and how it is related to sirtuins, mTOR, AMPK, fasting and especially to exercise.
I have been doing intermittent fasting for a very long time, even before i knew of its benefits for longevity and health, i found it helped with weight loss.Asclepius wrote: ↑Thu Oct 31, 2019 8:19 pm I've always found this to be extremely interesting, hence the reason i got started in IF in the first place. Switching to one meal a day is hard but not impossible, I find I get brain fog if i don't get that "second meal". Also i'm interested in gaining muscle mass, so the 2 meal balance seems to help me attain both goals.
After doing it for weeks (calories under 500 for 5 days, then a break) i found it had no effect on my brain or even energy.