Longevity ⇒ Dr Rhonda Patrick interviews David Sinclair -NMN, resveratrol and more

[Fred]

In this episode, Dr. David Sinclair discusses exciting new findings in the field of aging research, with special emphasis on the roles of sirtuins, resveratrol, and NAD+.

THE INTERVIEW
https://youtu.be/5DtWqzalEnc

DIVIDED INTO CLIPS
https://www.youtube.com/playlist?list=P ... A7xfiTcQZu

1. History and discovery of longevity genes
2. The link between sirtuins, calorie restriction, fasting and the insulin pathway
3. How NAD+ resets the circadian clock and regulates sirtuins
4. NAD+ and resveratrol levels affect the aging process
5. Why we lose NAD+ in aging—DNA repair & inflammation
6. Link between sirtuin pathway and the Horvath Clock
7. Discovery of genes that reset the Horvath Clock
8. Induced stem cells used to heal eye-related diseases
9. Dr. Sinclair explains reprogramming of epigenetics via the Informational Theory of Aging
10. NAD+ boosters: NR, NMN, and how they affect sirtuins
11. Does your body become fitter if your food is stressed out?
12. Resveratrol improves aortic stiffness (in rhesus monkeys)
13. Resveratrol's impact on the cardiovascular system
14. Dosage & supplement factors to consider for resveratrol supplementation
15. Resveratrol shown to have positivity impact on brand health (or in Alzheimer's Disease prevention
16. Increased NAD+ levels have positive impacts on vascular dementia
17. NR vs. NMN: dosing and effects on NAD+ levels
18. Why keeping NR & NMN supplements cold is crucial
19. NMN supplementation improved health parameters in mice
20. Why NR is more commonly used in studies (vs. NMN)
21. Dr. David Sinclair's personal dosage and supplementation habits
22. The relationship between sleep and insulin sensitivity
23. Dr. David Sinclair's personal sleep habits
24. Resveratrol: dosage considerations and effects on cardiovascular health

[Vandevalk1]

Thanks for this Fred! I didn’t know this was out there yet. Dr. Rhonda Patrick is so well versed and articulate all while keeping it interesting and easy to follow for the people without a medical or nutritionalists degree. Can’t wait to put this one on, on the ride home.

[Fred]

DIVIDED INTO CLIPS

https://www.youtube.com/playlist?list=P ... A7xfiTcQZu

1. History and discovery of longevity genes
2. The link between sirtuins, calorie restriction, fasting and the insulin pathway
3. How NAD+ resets the circadian clock and regulates sirtuins
4. NAD+ and resveratrol levels affect the aging process
5. Why we lose NAD+ in aging—DNA repair & inflammation
6. Link between sirtuin pathway and the Horvath Clock
7. Discovery of genes that reset the Horvath Clock
8. Induced stem cells used to heal eye-related diseases
9. Dr. Sinclair explains reprogramming of epigenetics via the Informational Theory of Aging
10. NAD+ boosters: NR, NMN, and how they affect sirtuins
11. Does your body become fitter if your food is stressed out?
12. Resveratrol improves aortic stiffness (in rhesus monkeys)
13. Resveratrol's impact on the cardiovascular system
14. Dosage & supplement factors to consider for resveratrol supplementation
15. Resveratrol shown to have positivity impact on brand health (or in Alzheimer's Disease prevention
16. Increased NAD+ levels have positive impacts on vascular dementia
17. NR vs. NMN: dosing and effects on NAD+ levels
18. Why keeping NR & NMN supplements cold is crucial
19. NMN supplementation improved health parameters in mice
20. Why NR is more commonly used in studies (vs. NMN)
21. Dr. David Sinclair's personal dosage and supplementation habits
22. The relationship between sleep and insulin sensitivity
23. Dr. David Sinclair's personal sleep habits
24. Resveratrol: dosage considerations and effects on cardiovascular health

[Longevity36]

These guys are givin us “fellacio” so to speak. It’s like they know what the answer is already to rewind the clock. And all these supplements are to basically keep us on ice! To keep our organs intact in the meantime . Has anyone read the book Sinclair wrote? It’s very telling. The direction these scientists are going is miraculous .and it’s not just Sinclair and his lab. It’s a bulk of them discovering and chiming in and sharing data. These young Asian scientists are running with it. It’s an awesome thing to read about. Imagine? Regrowing a damaged optic nerve. I wonder how it works ? For those that know what I’m talking about. When we rewind the clock. Will our teeth fall out and regrow?

[drkris69]

Great video I posted it last week on one of the other posts. Thanks for breaking it down like you did Fred.

[Longevity36]

So this question goes to ALIVE BY NATURE. Sinclair in this video mentions NMN having a poor shelf life & needing to be refrigerated or it could turn into a poisonous form of NMN. What’s up with this?

[Neddy99]

So this question goes to ALIVE BY NATURE. Sinclair in this video mentions NMN having a poor shelf life & needing to be refrigerated or it could turn into a poisonous form of NMN. What’s up with this?

The Part 18 interview " 18. Why keeping NR & NMN supplements cold is crucial [Link]" explains it fully.

NMN has a limited shelf life AND MUST BE KEPT COLD, unless it is in the stabilised form. [/size]

Degraded NMN turns into nasty nicotinamide which has a negative influence on certain genes/processes. In the words of Sinclair " It is something you would not want to take in high doses..........etc...... "

The question to Alive By Nature _ "Does the various forms of NMN sold by you have the NMN stabilised against degradation?"

[/size]