Miscellaneous Topics ⇒ Caloric Restriction Mimetics against Age-Associated Disease: hydroxycitrate, spermidine and resveratrol

[Fred]

I posted about the life-extending properties of spermidine earlier (yes, found in sperm...and soybeans, peas, wheatgerm and aged cheese) but this article has an extensive list of many other natural compounds that activate autophagy in different organisms.

The most effective seems to be hydroxycitrate, aspirin, resveratrol and spermidine. Worth a read!

The permanent or periodic reduction of calorie intake without malnutrition (caloric restriction and fasting) is the only strategy that reliably extends healthspan in mammals including non-human primates.

However, the strict and life-long compliance with these regimens is difficult, which has promoted the emergence of caloric restriction mimetics (CRMs).

We define CRMs as compounds that ignite the protective pathways of caloric restriction by promoting autophagy, a cytoplasmic recycling mechanism, via a reduction in protein acetylation.

Here, we describe the current knowledge on molecular, cellular, and organismal effects of known and putative CRMs in mice and humans. We anticipate that CRMs will become part of the pharmacological armamentarium against aging and age-related cardiovascular, neurodegenerative, and malignant diseases.

https://sci-hub.se/10.1016/j.cmet.2019.01.018

[canadahealthy]

I posted about the life-extending properties of spermidine earlier (yes, found in sperm...and soybeans, peas, wheatgerm and aged cheese) but this article has an extensive list of many other natural compounds that activate autophagy in different organisms. The most effective seems to be hydroxycitrate, aspirin, resveratrol and spermidine. Worth a read!

The permanent or periodic reduction of calorie intake without malnutrition (caloric restriction and fasting) is the only strategy that reliably extends healthspan in mammals including non-human primates.

However, the strict and life-long compliance with these regimens is difficult, which has promoted the emergence of caloric restriction mimetics (CRMs).

We define CRMs as compounds that ignite the protective pathways of caloric restriction by promoting autophagy, a cytoplasmic recycling mechanism, via a reduction in protein acetylation.

Here, we describe the current knowledge on molecular, cellular, and organismal effects of known and putative CRMs in mice and humans. We anticipate that CRMs will become part of the pharmacological armamentarium against aging and age-related cardiovascular, neurodegenerative, and malignant diseases.

https://sci-hub.se/10.1016/j.cmet.2019.01.018

Very interesting. I was pleasantly surprised to see aspirin in this list.