NAD+ therapy in age-related degenerative disorders: A benefit/risk analysis
"Most studies indicated that the NAD+ precursors NAM, NR, nicotinamide mononucleotide (NMN), and to a lesser extent NAD+ and NADH had a favourable outcome on several age-related disorders associated with the accumulation of chronic oxidative stress, inflammation and impaired mitochondrial function.
While these compounds presented with a limited acute toxicity profile, evidence is still quite limited and long-term human clinical trials are still nascent in the current literature.
Potential risks in raising NAD+ levels in various clinical disorders using NAD+ precursors include the accumulation of putative toxic metabolites, tumorigenesis and promotion of cellular senescence.
Therefore, NAD+ metabolism represents a promising target and further studies are needed to recapitulate the preclinical benefits in human clinical trials."
The authors conclude the review with: "Overall, consuming more nutritious plant foods and less meat remains the best guidelines to obtain "real‟ health benefits and improve healthspan."
https://sci-hub.se/downloads-ii/2020-01 ... 110831.pdf
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