https://pubmed.ncbi.nlm.nih.gov/32661350/
This new research demonstrates that fisetin is a promising agent for protecting against sepsis-induced inflammatory response and organ injury via inhibiting macrophage activation.
"Sepsis-induced multiple organ dysfunction and inflammatory response are life-threatening symptoms without effective treatment. Fisetin, a dietary flavonoid extracted from berries and family Fabaceae, has displayed neuroprotective and anti-oxidant activities. In this study we investigated whether fisetin exerted a protective effect against sepsis-induced multiple organ dysfunction in mouse cecum ligation and puncture (CLP) model. The mice were injected with fisetin (10 mg/kg, ip) 0.5 h prior to CLP, and sacrificed 18 h after CLP. We found that fisetin administration significantly alleviated CLP-induced lung, liver and kidney injury, as well as the expression levels of interleukin (IL)-6, tumor necrosis factor (TNF)-α and IL-1β in bronchoalveolar lavage fluid (BALF). "
Senolytics ⇒ Fisetin alleviates sepsis-induced multiple organ dysfunction
Fisetin alleviates sepsis-induced multiple organ dysfunction
Ph.D. student at Harvard Medical School, doing research on aging
Re: Fisetin alleviates sepsis-induced multiple organ dysfunction
Good article, wow fisetin is some powerful stuff!