Healthy Aging News and ResearchTelomeres

NewLifeScience
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Joined: Thu Aug 22, 2019 4:17 pm

Telomeres

Post by NewLifeScience »

So, while this may not relate directly to the processes of NMN, NAD+ and even Resvertatrol, it does relate to longevity.

Some people have longer telomeres (somewhat like tails) at the end of their DNA than others and it has long been thought, that the benefit to this feature is a longer life, since the tails essentially better protect the DNA from damage if they are longer.
Telomeres are the caps at the end of each strand of DNA that protect our chromosomes, like the plastic tips at the end of shoelaces.
https://www.tasciences.com/what-is-a-telomere.html
Inside the nucleus of a cell, our genes are arranged along twisted, double-stranded molecules of DNA called chromosomes. At the ends of the chromosomes are stretches of DNA called telomeres, which protect our genetic data, make it possible for cells to divide, and hold some secrets to how we age and get cancer.

Telomeres have been compared with the plastic tips on shoelaces, because they keep chromosome ends from fraying and sticking to each other, which would destroy or scramble an organism's genetic information.
https://learn.genetics.utah.edu/content ... telomeres/

I think the molecules we are speaking about protect our DNA in a different way, but perhaps the outcome is similar.

Although it seems NMN targets mostly mitochondrial DNA.. is there also a connection with nuclear DNA?


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AlbertY
Posts: 175
Joined: Mon Aug 12, 2019 4:01 pm
Location: Boston, MA

Re: Telomeres

Post by AlbertY »

NMN is actually working through Sirtuin, there are 7 sirtuins in sirtuin family; Some of them are in mitochondria and some of them are in the nucleus. So the answer might be both. :lol:
Ph.D. student at Harvard Medical School, doing research on aging
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