NAD+ Forums

The research if very clear that the biggest obstacle to boosting NAD+ levels is bioavailabilty.  We took the first step in solving that problem with our NMN and NAD+ powders and sublingual tablets.


Now we’ve taken an even bigger step with our advanced nanoliposome hydrogel featuring Control Release Kinetics designed for sublingual delivery.

LSG™ - combining the power of Liposomes & Sublingual delivery in advanced Gel technology

LSG™ nanoparticles are 20-40 nanometers – smaller than wavelengths of visible light – to maximize biological efficiency and precision performance. Smaller lipsomes penetrate the epithelium more readily, and are not filtered out by the liver as larger liposomes are.

This sublingual delivery system features Control Release Kinetics™, using sustained release liposomes to protect nutrients before release into systemic circulation with improved efficacy.

Our nanoparticulate Gel technology is formulated to improve active compound permeability across the epithelium, provide optimal solubilization and maximize systemic release kinetics.

LIPOSOMES

Liposomes are vesicles comprised of phospholipid molecules – the same molecules that comprise cell membranes. Liposomal drug delivery systems have excellent biocompatibility, low toxicity and lack of immune system activation.

Phospholipid molecules consist of a hydrophilic phosphate head and two hydrophobic fatty acid tails. These features enable liposomes to be able to transport hydrophobic and hydrophilic compounds effectively. Due to low absorption and bioavailability rates of traditional oral dietary capsules, the encapsulation of hydrophilic and hydrophobic nutrients within liposomes allows the active ingredient to bypass the destructive elements of the gastric system.

Liposomes release drug molecules by membrane fusion. To release the protected molecules to a site of action, the lipid bilayer fuses with other bilayers such as the cell membrane, delivering the liposome contents directly into the cells and tissues intact.

Read more about the power of Liposomes


SUBLINGUAL

Wikipedia: "When a chemical comes in contact with the mucous membrane beneath the tongue, it is absorbed. Because the connective tissue beneath the epithelium contains a profusion of capillaries, the substance then diffuses into them and enters the venous circulation. In contrast, substances absorbed in the stomach and intestines are subject to first-pass metabolism in the liver before entering the general circulation and typically have very poor bioavailability." 

The phospholipids in liposomes utilize the sublingual pathway to bring their payload directly into systemic circulation.

However, the quantity of liposomes delivered in liquid or spray is extremely limited and larger dosages are required, resulting in more of the product being swallowed.

The highly permeable sublingual entry site can be utilized for longer duration when administered in the form of our proprietary bioadhesive gel.

Read more about the power of Sublingual delivery.


GEL

With a 0.1-0.7 mm thick mucus layer, the oral cavity is an effective route of administration for mucoadhesive dosages.

Our mucoadhesive gel is designed to adhere to biological tissues, prolong residence time and maintain an optimal release rate. LSG™ is designed to assure prolonged retention time by dynamically increasing the viscosity of the gel after application.

Controlled Release Kinetics™ within the hydrogel technology provide further advanced bioavailability and efficacy.

Bioadhesive Hydrogel – Innovative Liposomal Suspension

Our LSG™ technology provides controlled-release performance with liposomes suspended in a natural bioadhesive gel. The loaded hydrogel increases contact time to improve performance over liquid products where production of saliva induces swallowing rather than sublingual absorption.

The mucoadhesive gel in our LSG products is designed to avoid rapid clearance of nutrient nanoparticles and maintain a long-term concentration gradient at the mucosal surface to ensure the unidirectional diffusion, and provides unsurpassed bioavailability with higher systemic delivery of nutrients to systemic circulation.

Read more about our Gel technology


LSG Products



See all our Liposomal Products


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I cant wait to try them!!!!

Liposomal is the way to go as far as delivery into the bloodstream. Better chance of crossing the blood brain barrier.

A new area and product introduction by ABN that shows they are continually evolving to stay “ahead of the game”
Exciting times ABN and well done..
Looking forward to trying the new products.

Thanks, we are excited to get this in peoples hands. The taste and user experience is awesome.

I'm confident this will be our most popular product, although I do still like taking the powder in the morning sometimes, for the instant hit.

Is this form also part of that human pharmacokinetics study that ABN is conducting?

The big question is what is the actual estimated multiplier of LSG vs other methods?

That is how much more do you actually get into your system vs existing methods. This ties to 1) purchasing price per gram of active substance, 2) required dose. I can't find anything definitive on the web, studies that show more Vitamin C gets via liposomal delivery method but not how much more and imagine every active agent is different.

Either way keen to try it, I am guessing at this stage at least 2x more effective based on price as a guide.

Sounds like a new and exciting product. Is there any research being done on the delivery method and blood values?

Fred wrote: ↑Wed Feb 12, 2020 3:03 am Is this form also part of that human pharmacokinetics study that ABN is conducting?

Yes, it is. That study was held up a bit so they could include this liposomal delivery method. Will be very interesting to see results for NMN and NAD+ sublingual, liposomal, capsules vs NR capsules.

Boxcost wrote: ↑Wed Feb 12, 2020 4:14 am The big question is what is the actual estimated multiplier of LSG vs other methods?

That is how much more do you actually get into your system vs existing methods. This ties to 1) purchasing price per gram of active substance, 2) required dose. I can't find anything definitive on the web, studies that show more Vitamin C gets via liposomal delivery method but not how much more and imagine every active agent is different.

Either way keen to try it, I am guessing at this stage at least 2x more effective based on price as a guide.

Yes, we will know more when the study underway now if published late spring or early summer.

For now, it is guesswork to be honest. Liposomal B-12 is 3-5x more bioavailable than capsules. Fisetin is 47x more. We believe it will be much closer to B-12.

It will be interesting to see the difference from sublingual powder vs Liposomal Sublingual Gel. LSG will surely show availability in circulation for longer than powder, but don't know if there will be a significant difference in how fast they take effect.