NAD+ Forums

AlbertY wrote: ↑Thu Apr 23, 2020 1:27 pm This is kind of cool since it is the currently MOST POTENT anti-aging drug and was used as IMMUOSUPRESSOR before people noticed its anti-aging property. Very excited to see the result of this.

jocko6889 wrote: ↑Thu Apr 23, 2020 7:31 pm

AlbertY wrote: ↑Thu Apr 23, 2020 1:27 pm This is kind of cool since it is the currently MOST POTENT anti-aging drug and was used as IMMUOSUPRESSOR before people noticed its anti-aging property. Very excited to see the result of this.

Why would you use an immunosuppressor to fight COVID-19? Isn't this a bit counter intuitive?

"Sirolimus is used with other medications to prevent rejection of a kidney transplant. This medication belongs to a class of drugs known as immunosuppressants. It works by weakening your body's defense system (immune system) to help your body accept the new organ as if it were your own."

https://www.webmd.com/drugs/2/drug-1770 ... al/details

TORC1 inhibition enhances immune function and reduces infections in the elderly

Inhibition of the mechanistic target of rapamycin (mTOR) protein kinase extends life span and ameliorates aging-related pathologies including declining immune function in model organisms.

The objective of this phase 2a randomized, placebo-controlled clinical trial was to determine whether low-dose mTOR inhibitor therapy enhanced immune function and decreased infection rates in 264 elderly subjects given the study drugs for 6 weeks.

A low-dose combination of a catalytic (BEZ235) plus an allosteric (RAD001) mTOR inhibitor that selectively inhibits target of rapamycin complex 1 (TORC1) downstream of mTOR was safe and was associated with a significant (P = 0.001) decrease in the rate of infections reported by elderly subjects for a year after study drug initiation.

In addition, we observed an up-regulation of antiviral gene expression and an improvement in the response to influenza vaccination
in this treatment group. Thus, selective TORC1 inhibition has the potential to improve immune function and reduce
infections in the elderly.

Fred wrote: ↑Fri Apr 24, 2020 4:31 am

jocko6889 wrote: ↑Thu Apr 23, 2020 7:31 pm

AlbertY wrote: ↑Thu Apr 23, 2020 1:27 pm This is kind of cool since it is the currently MOST POTENT anti-aging drug and was used as IMMUOSUPRESSOR before people noticed its anti-aging property. Very excited to see the result of this.

Why would you use an immunosuppressor to fight COVID-19? Isn't this a bit counter intuitive?

"Sirolimus is used with other medications to prevent rejection of a kidney transplant. This medication belongs to a class of drugs known as immunosuppressants. It works by weakening your body's defense system (immune system) to help your body accept the new organ as if it were your own."

https://www.webmd.com/drugs/2/drug-1770 ... al/details

I agree it seems counter-intuitive but a LOW DOSE of molecules with mTORC1 inhibitory function actually enhanced immune function and reduced infection rate in the elderly:

TORC1 inhibition enhances immune function and reduces infections in the elderly

Inhibition of the mechanistic target of rapamycin (mTOR) protein kinase extends life span and ameliorates aging-related pathologies including declining immune function in model organisms.

The objective of this phase 2a randomized, placebo-controlled clinical trial was to determine whether low-dose mTOR inhibitor therapy enhanced immune function and decreased infection rates in 264 elderly subjects given the study drugs for 6 weeks.

A low-dose combination of a catalytic (BEZ235) plus an allosteric (RAD001) mTOR inhibitor that selectively inhibits target of rapamycin complex 1 (TORC1) downstream of mTOR was safe and was associated with a significant (P = 0.001) decrease in the rate of infections reported by elderly subjects for a year after study drug initiation.

In addition, we observed an up-regulation of antiviral gene expression and an improvement in the response to influenza vaccination
in this treatment group. Thus, selective TORC1 inhibition has the potential to improve immune function and reduce
infections in the elderly.

https://www.researchgate.net/profile/Ha ... lderly.pdf

In addition, we observed an up-regulation of antiviral gene expression and an improvement in the response to influenza vaccination
in this treatment group. Thus, selective TORC1 inhibition has the potential to improve immune function and reduce
infections in the elderly.

NewLifeScience wrote: ↑Fri Apr 24, 2020 7:56 pm Good stuff!

I guess i am ready to start looking for a way to get my hands on both Rapamycin and Metformin.


Love this item:

In addition, we observed an up-regulation of antiviral gene expression and an improvement in the response to influenza vaccination
in this treatment group. Thus, selective TORC1 inhibition has the potential to improve immune function and reduce
infections in the elderly.