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I agree drkris69. I think the Mayo Clinic would have a very good idea in what they are trying to achieve with the Fisetin protocol. The only change is the dosage quantity having taken into account the AliveByScience products superior absorption.
I believe Jocko has put effort into converting the ABS Fisetin Product against normal Fisetin and has also taken into account the new Mayo Clinic Fisetin Protocol.Pilgrim79 wrote: ↑Sun Jun 20, 2021 4:13 pm At 81 years of age, and a faithful user of Alive by Science products, I thought I would weigh in on the topic as I am currently trying this Fisitin product; Here is the math as I see it:
2X pumps twice a day = 150mg of product. But, for some time now, ABS has been showing in various forms that the LSG Fisitin is 47X more bio available than than standard fisintin as used in the studies referenced. That is TIMES, not %. So, 150 mg X 47 = 7050 mg fisitin old powder equivalent.
I think that is a more than adequate dosage to get those old senolytic cells at attention and marching out the doors!
The real question now is, do I continue the dosage indefinitely or just do a couple of days a week,month, or a couple of days every three months? I am on day 2 today. I am at 180 lbs.
I read recently that loperamide, the active ingredient in Imodium has been used to induce autophagy in cancerous brain cells, and is nothing short of a life saver.TedB wrote: ↑Wed Jun 23, 2021 9:54 am I have learned that Fisetin acts on senescent cells, but a select few, like fat cells.
i wonder if there will eventually be a known list of these senolytics and which cells they target.
I'd like to know the full list of cells that Fisetin targets.
I don't think it is yet fully known.
https://www.fightaging.org/archives/202 ... s-in-mice/
https://alivebyscience.com/liposome-research/jocko6889 wrote: ↑Fri May 28, 2021 3:39 pmUnfortunately, the only way to rid the body of senescent cells is in high doses in a hit-and-run fashion, i.e. short bursts in high dosages is the key. You must shock the senescent cells into apoptosis.
Here's the math I came up with. To emulate the new Mayo Clinic protocol for Fisetin, the formula Mayo Cinic used was 20mg of Fisetin per 1 kg of weight. That translates to about 1,800mg for a 180lb person. To find the exact amount for your weight, you can use this pounds to kg converter:
https://www.google.com/search?q=pounds+to+kg+conversion
After getting the total number of kilograms (kg), multiply it times 20 to get the total milligrams of Fisetin you would consume per day.
Using the 180lb person and our Alive by Science Liposomal (LSG) Fisetin as an example,
2 pumps of Fisetin gel = 75mg
There are 120 pumps per bottle
Mayo Clinic target for 185lb person would be 1,800mg of Fisetin powder per day, but Liposomal Fisetin is significantly more bioavailable, so I halved it to 900mg per day, which is equal to 24 pumps per day.
24 pumps per day equals 72 pumps per month (3 days) or 360 pumps for entire 5 month protocol
Each bottle contains 120 pumps, so 3 bottles of Alive by Science liposomal Fisetin would cover the entire 5 month protocol
Liposomal is generally about 3 to 5 times more bioavailable than a powdered version. That's more of a guideline than a rule, though. I halved it because Fisetin is very safe and I believe it's better to be a little over the Mayo protocol than under. You could also call it a WAG and I wouldn't disagree with you.SunConure wrote: ↑Thu Jul 08, 2021 1:33 amhttps://alivebyscience.com/liposome-research/jocko6889 wrote: ↑Fri May 28, 2021 3:39 pmUnfortunately, the only way to rid the body of senescent cells is in high doses in a hit-and-run fashion, i.e. short bursts in high dosages is the key. You must shock the senescent cells into apoptosis.
Here's the math I came up with. To emulate the new Mayo Clinic protocol for Fisetin, the formula Mayo Cinic used was 20mg of Fisetin per 1 kg of weight. That translates to about 1,800mg for a 180lb person. To find the exact amount for your weight, you can use this pounds to kg converter:
https://www.google.com/search?q=pounds+to+kg+conversion
After getting the total number of kilograms (kg), multiply it times 20 to get the total milligrams of Fisetin you would consume per day.
Using the 180lb person and our Alive by Science Liposomal (LSG) Fisetin as an example,
2 pumps of Fisetin gel = 75mg
There are 120 pumps per bottle
Mayo Clinic target for 185lb person would be 1,800mg of Fisetin powder per day, but Liposomal Fisetin is significantly more bioavailable, so I halved it to 900mg per day, which is equal to 24 pumps per day.
24 pumps per day equals 72 pumps per month (3 days) or 360 pumps for entire 5 month protocol
Each bottle contains 120 pumps, so 3 bottles of Alive by Science liposomal Fisetin would cover the entire 5 month protocol
From the table, at the same dose, intraperitoneal administration of LSG fisetin seems to have on average 27x more plasma concentration compared to regular fisetin. Obviously we (human) are not doing intraperitoneal injection when taking fisetin.
What's the logic behind halving the dose for LSG fisetin (900mg for a 180lb person)? Is this because the intravenous comparison is more relevant than intraperitoneal? In this case Cmax ratio of LSG fisetin and regular fisetin is 5/3, no where near 27x
I see now, thanks for the clarification!jocko6889 wrote: ↑Thu Jul 08, 2021 6:25 amLiposomal is generally about 3 to 5 times more bioavailable than a powdered version. That's more of a guideline than a rule, though. I halved it because Fisetin is very safe and I believe it's better to be a little over the Mayo protocol than under. You could also call it a WAG and I wouldn't disagree with you.SunConure wrote: ↑Thu Jul 08, 2021 1:33 amhttps://alivebyscience.com/liposome-research/jocko6889 wrote: ↑Fri May 28, 2021 3:39 pm
Unfortunately, the only way to rid the body of senescent cells is in high doses in a hit-and-run fashion, i.e. short bursts in high dosages is the key. You must shock the senescent cells into apoptosis.
Here's the math I came up with. To emulate the new Mayo Clinic protocol for Fisetin, the formula Mayo Cinic used was 20mg of Fisetin per 1 kg of weight. That translates to about 1,800mg for a 180lb person. To find the exact amount for your weight, you can use this pounds to kg converter:
https://www.google.com/search?q=pounds+to+kg+conversion
After getting the total number of kilograms (kg), multiply it times 20 to get the total milligrams of Fisetin you would consume per day.
Using the 180lb person and our Alive by Science Liposomal (LSG) Fisetin as an example,
2 pumps of Fisetin gel = 75mg
There are 120 pumps per bottle
Mayo Clinic target for 185lb person would be 1,800mg of Fisetin powder per day, but Liposomal Fisetin is significantly more bioavailable, so I halved it to 900mg per day, which is equal to 24 pumps per day.
24 pumps per day equals 72 pumps per month (3 days) or 360 pumps for entire 5 month protocol
Each bottle contains 120 pumps, so 3 bottles of Alive by Science liposomal Fisetin would cover the entire 5 month protocol
From the table, at the same dose, intraperitoneal administration of LSG fisetin seems to have on average 27x more plasma concentration compared to regular fisetin. Obviously we (human) are not doing intraperitoneal injection when taking fisetin.
What's the logic behind halving the dose for LSG fisetin (900mg for a 180lb person)? Is this because the intravenous comparison is more relevant than intraperitoneal? In this case Cmax ratio of LSG fisetin and regular fisetin is 5/3, no where near 27x