NMN ⇒ NMN Dosage

[smokinjoe]

It is recommended you take something to replace lost methyl groups at the dose we're talking about. I was using 750mg of TMG (trimethylglycine) per day until I read that Sinclair recently switched from that to a combination of Methyl Folate and Methyl B12. Maybe this is a healthier alternative, so I've done the same. Didn't know his dosage of each so I'm guessing on that until I get more info.

Hey, this is the first time I've seen anyone comment "lost methyl groups". Could someone explain what this means, please?

Byproducts from NAD+ use are excreted out the urine along with a methyl group. Depending on how much NMN you are using, this could cause a shortage of methyl groups, in which case you should supplement. Methyl groups are needed for synthesizing creatine for muscle and dopamine for the brain. Having a shortage could mean feeling tired and/or depressed.

Can this happen with SL NMN? Or just NAD+?

[jocko6889]

Is there somewhere I can hear or read the Glenda interview?

It's not posted anywhere to my knowledge yet.

How did you find out about it?

The interview was posted briefly on a Facebook group page but taken down for unknown reasons. Waiting the see whether it will reappear on YouTube somewhere.

[jocko6889]

Hey, this is the first time I've seen anyone comment "lost methyl groups". Could someone explain what this means, please?

Byproducts from NAD+ use are excreted out the urine along with a methyl group. Depending on how much NMN you are using, this could cause a shortage of methyl groups, in which case you should supplement. Methyl groups are needed for synthesizing creatine for muscle and dopamine for the brain. Having a shortage could mean feeling tired and/or depressed.

Can this happen with SL NMN? Or just NAD+?

Either NMN or NAD+ can do it.

[canadahealthy]

I would imagine one symptom of this could be fatigue, yes?

I feel more and more invigorated taking NMN and RSV. So if i was raising the dose level and began to feel fatigue, i would suspect i am maybe taking too much.

I would rather take less and NOT experience lost methyl groups than have to take more suppliments.

[drkris69]

I recently added Methyl folate and Methyl B12 after reading the post from Jocko and I can honestly say I feel a difference in my mood and energy throughout the day. Definitely a nice compliment with taking NMN.

[Drdavid]

Sci Rep. 2019; 9: 9772.
Published online 2019 Jul 5. doi: 10.1038/s41598-019-46120-z
PMCID: PMC6611812
PMID: 31278280
Safety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults
Dietrich Conze,#1 Charles Brenner,corresponding author2 and Claire L. Krugercorresponding author#1

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611812/

[canadahealthy]

Jocko how much of the methyl folate and B12 are you taking? What MG or MCG?

5,000 mcg of Methyl B12
https://www.amazon.com/gp/aw/d/B07N4JZC ... asin_title

1,000 mcg of Methyl Folate
https://www.amazon.com/gp/aw/d/B07T8C9N ... asin_title

I'm taking one capsule of each per day. These are complete WAG's (wild-ass guesses) as Sinclair has not stated how much of each he is taking in place of TMG. So use the "how do I feel" method for now. If tired and/or depressed you are probably low on methyl groups, so up your dose. Having a little extra in your system is not going to hurt you if you overshoot.

It's like a full body recipe.

I wonder if the very elderly (80+ ?) will find themselves getting low on methyl Groups with moderate doses of NMN??

Would age be a factor here?

[Andreas]

5,000 mcg of Methyl B12
https://www.amazon.com/gp/aw/d/B07N4JZC ... asin_title
1,000 mcg of Methyl Folate
https://www.amazon.com/gp/aw/d/B07T8C9N ... asin_title

It can be tough to find the same products here in Norway as you have in the US (I've already asked you about Trans-Resveratrol because that's real difficult to find here). I found one supplement that I think included both Methyl B12 and Methyl Folate, but at smaller doses, am I correct or is it the wrong form?

Vitamin B1 (tiaminmononitrat) 31 mg 2818%
Vitamin B2 (riboflavin-5-fosfat) 25 mg 1786%
Niacin (inositolheksaniacinat) 50 mg 313%
Pantotensyre (kalsium-D-pantotenat)50 mg 833%
Vitamin B6 (pyridoksal-5-fosfat) 12 mg 857%
Biotin (D-biotin) 200 µg 400%
Folat (kalsium-L-metylfolat) 400 µg 200%
Vitamin B12 (metylkobalamin) 100 µg 4000%
Kolin (kolinbitartrat) 100 mg
Inositol (inositol/inositolheksaniacinat) 100 mg
Lecitin fra solsikke (fosfolipidblanding) 50 mg

Do you think the doses are OK and/or should I try to find pure supplements that focus on either Methyl B12 or Methyl Folate, instead of finding a supplement that "has it all"?

[jocko6889]

If it were me, I'd focus on finding methyl B12 and methyl folate. In the meantime, until you find it, just take TMG.

[Andreas]

I don't know if there has been any focus here on this study from 2018, that links an increased risk of lung cancer with high levels of B12 (regardless of whether you were a smoker or not). It received attention here in Norway, due to this article (unfortunately in Norwegian). It reduced the amount of people getting shots with B12 and the recommendation coming out of it was to avoid taking B12, unless you were deficient. Since the people here on this site are bio-hacking, everything comes with a risk, so it becomes a risk-reward question.

If it were me, I'd focus on finding methyl B12 and methyl folate. In the meantime, until you find it, just take TMG.

TMG could be a problem for me, because according to this study: TMG supplementation lowers homocysteine but also raises LDL-cholesterol. As I'm working to reduce my LDL levels, it could be counter-productive to take take TMG. And because of the above mentioned question about B12, I'm more on the fence now, especially since it's so hard to find "pure" Methyl B12 in Norway.