https://www.youtube.com/watch?v=0mD-wupqvQE
Some points that stood out to me:
- He says it's still possible that removing senescent cells may play both positive and negative roles in ways we don't yet understand
- He actually isn't confident that this is safe yet. They are only attempting to treat fairly frail/sick individuals in the trials who have no better options, but does not recommend it to healthy people because there are too man unknowns
- He thinks this "hit and run" approach (large occasional doses) is the way to go with senolytics and does not think daily dosing is a good idea
- Fisetin doesn't kill the cells, but instead interrupts the protective capacities of the senescent cells which allows them to be killed though normal processes