Re: Eliminating senescent cells may be harmful?
Posted: Sat Aug 07, 2021 12:10 am
These forums are for discussion of NAD+ Boosters and other longevity products
https://renuebyscience.com/forums/
https://www.lifespan.io/news/are-senoly ... longevity/Here is the argument: 1) theoretically, senolytics should make things worse and 2) the available data support this theoretical concern. To use an analogy, imagine that you have a factory in which 10 of the 100 factory workers are feeling overworked and tired. Furthermore, their complaints are disrupting the other workers. You have two possible interventions. You can:You have to keep a few points in mind. 1) Will the stem cells populate as desired? 2) If you do get a stem cell population, that requires cell division, which shortens telomeres, which accelerates cell senescence, and once again you have accelerated pathology. 3) Why would you bother recruiting stem cells when you can much more easily reset cell senescence in the resident cells of the tissue? 4) The long-term data (what there is of it) supports the failure of senolytics.
- Fire the 10 workers, thereby removing the complainers. The result is that the remaining 90 workers are now overworked, and they, too, begin to complain. You end up with 30 workers who are now complaining and disrupting your factory. This is the senolytic approach.
Again: remember where those “new cells” come from: you are accelerating senescence in the stem cell pool. The only way to “replace them with healthy working cells” is to simply and effectively reset gene expression, taking senescing cells and turning them into functionally young cells. This was first demonstrated 21 years ago in human cells in vitro, then repeatedly in human tissues in vitro.
Sure Evan so look in the forum and find the title for Fisetin. There you will find everything about the protocol and also what Fisetin is and does.
Here's my original post linked below about the new Mayo Clinic protocol. The short version is for a 185lb person, you would do 24 pumps of our liposomal fisetin per day for 3 days, pause 1 month, then repeat 24 pumps per day for 3 days with 1 month rest between. You would do this cycle of 3 days on fisetin and 1 month rest for 5 months total.
This is exactly what I want my sister to do, and I am getting her the PSG Fisetinjocko6889 wrote: ↑Fri Aug 13, 2021 12:38 pmHere's my original post linked below about the new Mayo Clinic protocol. The short version is for a 185lb person, you would do 24 pumps of our liposomal fisetin per day for 3 days, pause 1 month, then repeat 24 pumps per day for 3 days with 1 month rest between. You would do this cycle of 3 days on fisetin and 1 month rest for 5 months total.
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