Liposomal NMN Safety
Posted: Tue May 10, 2022 6:13 pm
Hi All,
In this Renue by Science video on Youtube (https://www.youtube.com/watch?v=-3RSi25g4LY), a comment (quoted below) raises the question about the safety of Liposomal NMN, and whether it has been tested on animals. The response from Renue By Science mentions a human study that has been done in Melbourne, but that the results are not yet out. Is there any update on this, considering that the response is from 8 months ago? Thanks!
User comment by Paulf Wolf: "Liposomal formulations of NMN make me nervous because cells have a way to control the amount of NMN inside. It gets converted to NR and then back into NMN if needed, but NMN doesn't seem to be able to go through the cell wall. The liposomes go through the cell walls with no controls at all. The normal way to get drugs to penetrate through tissues, such as the skin, is by using surfactants which open the pores. Then the drug goes through the pores, or around the cells, instead of going into them and then, supposedly, coming out the other side. The science behind this is not good. How can the cells repackage the NMN into new vesicles so it comes out from the opposite side? Have any of these liposomal formulations ever been tested on animals?"
Renue By Science response: "Renue has been tested on humans, but the extreme lockdown in Melbourne has held up publishing the results for 18 months now."
In this Renue by Science video on Youtube (https://www.youtube.com/watch?v=-3RSi25g4LY), a comment (quoted below) raises the question about the safety of Liposomal NMN, and whether it has been tested on animals. The response from Renue By Science mentions a human study that has been done in Melbourne, but that the results are not yet out. Is there any update on this, considering that the response is from 8 months ago? Thanks!
User comment by Paulf Wolf: "Liposomal formulations of NMN make me nervous because cells have a way to control the amount of NMN inside. It gets converted to NR and then back into NMN if needed, but NMN doesn't seem to be able to go through the cell wall. The liposomes go through the cell walls with no controls at all. The normal way to get drugs to penetrate through tissues, such as the skin, is by using surfactants which open the pores. Then the drug goes through the pores, or around the cells, instead of going into them and then, supposedly, coming out the other side. The science behind this is not good. How can the cells repackage the NMN into new vesicles so it comes out from the opposite side? Have any of these liposomal formulations ever been tested on animals?"
Renue By Science response: "Renue has been tested on humans, but the extreme lockdown in Melbourne has held up publishing the results for 18 months now."