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Is Urolithin A the next longevity supplement?
Posted: Tue May 24, 2022 6:10 am
by Boxcost
Urolithins exerts potent anticancer properties, are anti-inflammatory and neuroprotective compounds.
A recent trial demonstrated improved muscle strength:
https://medicalxpress.com/news/2022-05- ... iddle.html
The study was sponsored by what it looks like one of the few companies that make Urolithin A in supplement form available (expensive too!):
https://www.timelinenutrition.com/
Urolithin A is actually not found in food, but produced by our gut bacteria when we consume ellagic acid, one of the keys ones:
https://www.sciencedirect.com/science/a ... 4618301324
Ellagic acid is found in a number of foods:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015040/
So the top foods to target:
pomegranates
apples
grapes
strawberries
raspberries
cranberries
cloudberries
walnuts
pistachios
cashews
pecans
I have been tracking my gut bacteria for a few years, over the last year I added pure pomegranate juice (just a little per day, like a cup) and have also been prioritising pomegranates more into my diet when I can. I have also added now a lot of the pomegranate white stuff (very high in Ellagic acid) and the seeds into my regular smoothie. I re-tested my gut bacteria and the percentage of the key bacteria Bifidobacterium pseudocatenulatum went from 1.25% (August 21) to 13.8% (March 22) of my total sample in less than a year
I probably don't need to supplement Urolithin A, unless of course RBS comes out with a cost effective LIPO version
Re: Is Urolithin A the next longevity supplement?
Posted: Tue May 24, 2022 8:52 am
by Newage
Boxcost wrote: ↑Tue May 24, 2022 6:10 am
Urolithins exerts potent anticancer properties, are anti-inflammatory and neuroprotective compounds.
A recent trial demonstrated improved muscle strength:
https://medicalxpress.com/news/2022-05- ... iddle.html
The study was sponsored by what it looks like one of the few companies that make Urolithin A in supplement form available (expensive too!):
https://www.timelinenutrition.com/
Urolithin A is actually not found in food, but produced by our gut bacteria when we consume ellagic acid, one of the keys ones:
https://www.sciencedirect.com/science/a ... 4618301324
Ellagic acid is found in a number of foods:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015040/
So the top foods to target:
pomegranates
apples
grapes
strawberries
raspberries
cranberries
cloudberries
walnuts
pistachios
cashews
pecans
I have been tracking my gut bacteria for a few years, over the last year I added pure pomegranate juice (just a little per day, like a cup) and have also been prioritising pomegranates more into my diet when I can. I have also added now a lot of the pomegranate white stuff (very high in Ellagic acid) and the seeds into my regular smoothie. I re-tested my gut bacteria and the percentage of the key bacteria Bifidobacterium pseudocatenulatum went from 1.25% (August 21) to 13.8% (March 22) of my total sample in less than a year
I probably don't need to supplement Urolithin A, unless of course RBS comes out with a cost effective LIPO version
Very good information Boxcost.
As they say “the gut is the second brain” and you obviously give it the priority that it deserves. Wellbeing can start and finish with one’s gut bacteria…
I am also a strong believer in the benefits of pure Pomegranate Juice (Organic Nuris no sugar added ) or the fruit itself when available..
Re: Is Urolithin A the next longevity supplement?
Posted: Tue May 24, 2022 7:21 pm
by vauss88
Boxcost wrote: ↑Tue May 24, 2022 6:10 am
Urolithins exerts potent anticancer properties, are anti-inflammatory and neuroprotective compounds.
A recent trial demonstrated improved muscle strength:
https://medicalxpress.com/news/2022-05- ... iddle.html
The study was sponsored by what it looks like one of the few companies that make Urolithin A in supplement form available (expensive too!):
https://www.timelinenutrition.com/
Urolithin A is actually not found in food, but produced by our gut bacteria when we consume ellagic acid, one of the keys ones:
https://www.sciencedirect.com/science/a ... 4618301324
Ellagic acid is found in a number of foods:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015040/
So the top foods to target:
pomegranates
apples
grapes
strawberries
raspberries
cranberries
cloudberries
walnuts
pistachios
cashews
pecans
I have been tracking my gut bacteria for a few years, over the last year I added pure pomegranate juice (just a little per day, like a cup) and have also been prioritising pomegranates more into my diet when I can. I have also added now a lot of the pomegranate white stuff (very high in Ellagic acid) and the seeds into my regular smoothie. I re-tested my gut bacteria and the percentage of the key bacteria Bifidobacterium pseudocatenulatum went from 1.25% (August 21) to 13.8% (March 22) of my total sample in less than a year
I probably don't need to supplement Urolithin A, unless of course RBS comes out with a cost effective LIPO version
I investigated Urolithin A a year or two ago, and what was interesting was that humans broke down into three different categories: 1) those who produced urolithin A without supplementation, 2) those who could produce urolithin A with supplementation, and 3) those would couldn't produce urolithin A no matter what.
Re: Is Urolithin A the next longevity supplement?
Posted: Tue May 24, 2022 9:28 pm
by JanCOhio
vauss88 wrote: ↑Tue May 24, 2022 7:21 pm
Boxcost wrote: ↑Tue May 24, 2022 6:10 am
Urolithins exerts potent anticancer properties, are anti-inflammatory and neuroprotective compounds.
A recent trial demonstrated improved muscle strength:
https://medicalxpress.com/news/2022-05- ... iddle.html
The study was sponsored by what it looks like one of the few companies that make Urolithin A in supplement form available (expensive too!):
https://www.timelinenutrition.com/
Urolithin A is actually not found in food, but produced by our gut bacteria when we consume ellagic acid, one of the keys ones:
https://www.sciencedirect.com/science/a ... 4618301324
Ellagic acid is found in a number of foods:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015040/
So the top foods to target:
pomegranates
apples
grapes
strawberries
raspberries
cranberries
cloudberries
walnuts
pistachios
cashews
pecans
I have been tracking my gut bacteria for a few years, over the last year I added pure pomegranate juice (just a little per day, like a cup) and have also been prioritising pomegranates more into my diet when I can. I have also added now a lot of the pomegranate white stuff (very high in Ellagic acid) and the seeds into my regular smoothie. I re-tested my gut bacteria and the percentage of the key bacteria Bifidobacterium pseudocatenulatum went from 1.25% (August 21) to 13.8% (March 22) of my total sample in less than a year
I probably don't need to supplement Urolithin A, unless of course RBS comes out with a cost effective LIPO version
I investigated Urolithin A a year or two ago, and what was interesting was that humans broke down into three different categories: 1) those who produced urolithin A without supplementation, 2) those who could produce urolithin A with supplementation, and 3) those would couldn't produce urolithin A no matter what.
That's pretty interesting. Were there any consequences from the inability to produce urolithin A?
Re: Is Urolithin A the next longevity supplement?
Posted: Wed May 25, 2022 6:33 am
by Boxcost
JanCOhio wrote: ↑Tue May 24, 2022 9:28 pm
vauss88 wrote: ↑Tue May 24, 2022 7:21 pm
Boxcost wrote: ↑Tue May 24, 2022 6:10 am
Urolithins exerts potent anticancer properties, are anti-inflammatory and neuroprotective compounds.
A recent trial demonstrated improved muscle strength:
https://medicalxpress.com/news/2022-05- ... iddle.html
The study was sponsored by what it looks like one of the few companies that make Urolithin A in supplement form available (expensive too!):
https://www.timelinenutrition.com/
Urolithin A is actually not found in food, but produced by our gut bacteria when we consume ellagic acid, one of the keys ones:
https://www.sciencedirect.com/science/a ... 4618301324
Ellagic acid is found in a number of foods:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015040/
So the top foods to target:
pomegranates
apples
grapes
strawberries
raspberries
cranberries
cloudberries
walnuts
pistachios
cashews
pecans
I have been tracking my gut bacteria for a few years, over the last year I added pure pomegranate juice (just a little per day, like a cup) and have also been prioritising pomegranates more into my diet when I can. I have also added now a lot of the pomegranate white stuff (very high in Ellagic acid) and the seeds into my regular smoothie. I re-tested my gut bacteria and the percentage of the key bacteria Bifidobacterium pseudocatenulatum went from 1.25% (August 21) to 13.8% (March 22) of my total sample in less than a year
I probably don't need to supplement Urolithin A, unless of course RBS comes out with a cost effective LIPO version
I investigated Urolithin A a year or two ago, and what was interesting was that humans broke down into three different categories: 1) those who produced urolithin A without supplementation, 2) those who could produce urolithin A with supplementation, and 3) those would couldn't produce urolithin A no matter what.
That's pretty interesting. Were there any consequences from the inability to produce urolithin A?
Yes, I understand that some cancer targeting medical treatments do not work without the specific gut bacteria (In one of Dr William Li's interviews or presentations, will need to track it down). Not sure if the impact to cancer in this case related to Urolithin A or any other metabolites that gut bacteria produce. Our gut bacteria are in effect vitamin factories, both consume and output vitamins, etc. We still don't know the full scope of what they do or how important they are to our health. As an example and interesting fact that Bears when in hibernation, it is their gut bacteria producing some critical B vitamins that keeps them alive.
In summary I suppose the "consequences" on less or no Urolithin A based on the current science I would assume to be reduced protection against cancer, inflammation, muscle loss and neurodegenerative diseases.
Re: Is Urolithin A the next longevity supplement?
Posted: Wed May 25, 2022 4:55 pm
by TKK
I have consistently taken between [url=tel:500-1000]500-1000[/url] mg of Urolithin A daily (via Mitopure supplement) for the last ten months or so. Prior to that, for many years I had been drinking 8-12,oz of pomegranate juice daily. I have never been tested to see if I am one of the 40% of the population whose gut microbiome naturally produces Urolithin A. I have since stopped drinking pomegranate juice.
Several months after starting mitopure, I did notice an increase in muscular endurance during weight training. Whether that was due to the Mitopure is hard to say. For all I know, the benefits I was seeing could have been from the near daily consumption of yogurt, which I mix the Mitopure powder into.
In any event, I am feeling great and the research on Urolithin A continues to be encouraging, and I see no need to go back to consuming the extra sugar pomagranate juice provides.
Re: Is Urolithin A the next longevity supplement?
Posted: Thu May 26, 2022 6:49 pm
by NewLifeScience
I am not sure if it ranks with CaAKG and NMN for longevity (not sure it doesn't either for that matter), but i know my mom needs to be taking it.
thank you for this research, TKK.
Re: Is Urolithin A the next longevity supplement?
Posted: Fri May 27, 2022 5:11 pm
by jocko6889
New study:
Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults
https://www.cell.com/cell.../fulltext/S ... 22)00158-6