Senolytics ⇒ Mayo Clinc Protocol?

[gabby]

When researching the Mayo Clinc Prototcol on Pub Med I discovered that "Patents on senolytic drugs and their uses are held by Mayo Clinic and the University of Minnesota"  While I am not discounting the benefits of this protocol, before I begin it, I wanted to make sure there was no conflick of interest here and it appears there is. Any thoughts? 

[Newage]

When researching the Mayo Clinc Prototcol on Pub Med I discovered that "Patents on senolytic drugs and their uses are held by Mayo Clinic and the University of Minnesota"  While I am not discounting the benefits of this protocol, before I begin it, I wanted to make sure there was no conflick of interest here and it appears there is. Any thoughts? 

 

I personally see it as a good protocol to put in place on a consistent basis.
 

[michaeljkelly]

There are a lot of studies for senolytics going on, including Quercitin and Dasantanib. But Fisetin has shown to get rid of senescent cells, especially fat cells.

I have used it. I have benefitted from it. I recommend googling NIH and fisetin to get studies posted on the Institute of health.

[NewLifeScience]

When researching the Mayo Clinc Prototcol on Pub Med I discovered that "Patents on senolytic drugs and their uses are held by Mayo Clinic and the University of Minnesota"  While I am not discounting the benefits of this protocol, before I begin it, I wanted to make sure there was no conflick of interest here and it appears there is. Any thoughts? 

 

I am getting less cautious about disclosed conflicts of interest, because these days, everyone has at least one. Science is becoming more political and even militant, as it were.

Here is a more thorough overview that I think you will like:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197652/

and

https://pubmed.ncbi.nlm.nih.gov/30279143/
 

[jocko6889]

When researching the Mayo Clinc Prototcol on Pub Med I discovered that "Patents on senolytic drugs and their uses are held by Mayo Clinic and the University of Minnesota"  While I am not discounting the benefits of this protocol, before I begin it, I wanted to make sure there was no conflick of interest here and it appears there is. Any thoughts? 

 

The Mayo Clinic protocol on fisetin does not recommend a particular brand, so I think they are pretty above board on keeping profit motive out of their studies, unlike some others.
 

[gabby]

Thanks everyone for your responses. Very helpful. 
  I just completed my first month of the 3 day protocol. I had no side effects and nothing unusual happened. I will continue on to the next month and do the whole 5 months protocol. I am wondering if there is any benefit to taking the "one pill daily dose" for the rest of this month or should I not take any at all until my next 3 pill dose? 

[drkris69]

Personally, I would follow the 5 month protocol to the T. I think you will be impressed with the outcome. Fisetin is a very powerful Senolytic.

[gabby]

Personally, I would follow the 5 month protocol to the T. I think you will be impressed with the outcome. Fisetin is a very powerful Senolytic.

 

Yes I plan to complete the entire 5 month protocol. My previous question was if I should also continure to do my "daily" 125mg dose after the 3 day high dose, that I've been doing for awhile now. Not sure if that will be too much in conjuction with the Mayo protocol. 
 

[drkris69]

That's why I responded, no I don't you should continue with a daily dose of 125 mgs of Fisetin. Stick to the 3 day 5 mo cycle. It is the best way to rid the body of bad cells. 

[jocko6889]

Personally, I would follow the 5 month protocol to the T. I think you will be impressed with the outcome. Fisetin is a very powerful Senolytic.


 

Yes I plan to complete the entire 5 month protocol. My previous question was if I should also continure to do my "daily" 125mg dose after the 3 day high dose, that I've been doing for awhile now. Not sure if that will be too much in conjuction with the Mayo protocol. 
 

 

The only caveat is if you are thin with low BMI and fat, you shouldn't do the protocol.  It does target adipose (fat) senescent cells and if you have very little, you run the risk of getting rid of some of the essential senescent cells used for things like healing wounds.