NAD+ Forums

orian wrote: ↑Sun Jan 29, 2023 10:13 am Hi, I'm new here. I sometimes go on the Longecity forum, but in the past few years, that forum isn't as active as it used to be, and so my posts there are seldom replied to. 

A week ago I came across a senolytic supplement by a company called Life Extension. It's called
"Life Extension's Senolytic Activator". It has 36 capsules in the bottle, and you only need to take 3 capsules a week. Each capsule contains:

Bio-Fisetin 312 mg
Theaflavins 275 mg
Bio-Quercetin 74 mg
Apigenin 50 mg
 
If you took 3 capsules a week, you would be getting the following dosages:
 
Bio-Fisetin 936 mg
Theaflavins 825 mg
Bio-Quercetin 222 mg
Apigenin 150 mg
 
These amounts seem too low to properly clear out senescent cells, given that to do so using the customary "hit and miss" protocol of taking fisetin alone in large dosages every few months requires a dosage of 1500 mg each day for two days.

Life extension say that their product is 25 times more bioavailable than other fisetin products, but they don't give any information for that claim.

Besides, fisetin alone when mixed with an oily substance becomes bioavailable. I have used the "hit and miss" protocol in the past, mixing fisetin with olive oil.

So my question is, is Life Extension's product worth buying? Are any of you taking it, and if so what do you think of it?
 
 

 

jocko6889 wrote: ↑Mon Jan 30, 2023 9:58 pm

orian wrote: ↑Sun Jan 29, 2023 10:13 am Hi, I'm new here. I sometimes go on the Longecity forum, but in the past few years, that forum isn't as active as it used to be, and so my posts there are seldom replied to. 

A week ago I came across a senolytic supplement by a company called Life Extension. It's called
"Life Extension's Senolytic Activator". It has 36 capsules in the bottle, and you only need to take 3 capsules a week. Each capsule contains:

Bio-Fisetin 312 mg
Theaflavins 275 mg
Bio-Quercetin 74 mg
Apigenin 50 mg
 
If you took 3 capsules a week, you would be getting the following dosages:
 
Bio-Fisetin 936 mg
Theaflavins 825 mg
Bio-Quercetin 222 mg
Apigenin 150 mg
 
These amounts seem too low to properly clear out senescent cells, given that to do so using the customary "hit and miss" protocol of taking fisetin alone in large dosages every few months requires a dosage of 1500 mg each day for two days.

Life extension say that their product is 25 times more bioavailable than other fisetin products, but they don't give any information for that claim.

Besides, fisetin alone when mixed with an oily substance becomes bioavailable. I have used the "hit and miss" protocol in the past, mixing fisetin with olive oil.

So my question is, is Life Extension's product worth buying? Are any of you taking it, and if so what do you think of it?
 
 


 

You didn't mention the price but in my opinion, these are pretty low and ineffectual doses of each.  Check out the same supplements over at renuebyscience.com.  We don't carry Theaflavins but do carry the others in a liposomal version, which is much more bioavailable than what you're using now.

 

Newage wrote: ↑Mon Jan 30, 2023 11:15 pm I totally agree Jocko. Along with the Fisetin Monthly Protocol I also use a couple of pumps daily of the RBS Lipo Fisetin as a consistent maintenance dose..


 

YouthRenue wrote: ↑Wed Feb 01, 2023 3:23 pm How much Fisetin is needed to properly clear out senescent cells?

I'm on the Renue Lipo Acticator which is 245mg a week if taken daily? Do we think is should start taking twice as much?

 

You will need higher doses of fisetin than the Activator product provides.  I suggest buying the RBS LIPO Fisetin capsules and taking 3 per day for 3 straight days (dose for a typical 190lb person so adjust accordingly), then rest one month, then repeat this on/off cycle for 4 more months. "