STUDY: Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults
Posted: Tue Feb 14, 2023 10:38 am
In a first of its kind randomized controlled trial an international team of researchers shows that caloric restriction can slow the pace of aging in healthy adults. The CALERIE intervention slowed pace of aging measured from participants' blood DNA methylation using an algorithm.
The trial randomized 220 healthy men and women at three sites in the U. S. to a 25 percent calorie-restriction or normal diet for two years.
The intervention represented a 2-3 percent slowing in the pace of aging, which in other studies translates to a 10-15 percent reduction in mortality risk, an effect similar to a smoking cessation intervention.
Full Study: https://www.nature.com/articles/s43587-022-00357-y
The trial randomized 220 healthy men and women at three sites in the U. S. to a 25 percent calorie-restriction or normal diet for two years.
The intervention represented a 2-3 percent slowing in the pace of aging, which in other studies translates to a 10-15 percent reduction in mortality risk, an effect similar to a smoking cessation intervention.
Full Study: https://www.nature.com/articles/s43587-022-00357-y
