Clinical study affirms Niagen nicotinamide riboside ingredient’s long-term safety, optimal dosing
Posted: Fri Jul 26, 2019 7:14 pm
ChromaDex (Los Angeles) announced a recently published clinical study affirming the safe use of the company’s Niagen nicotinamide riboside (NR) ingredient. NR is a member of the vitamin B3 family and plays a role in the production of nicotinamide adenine dinucleotide (NAD+), “an essential molecule found in every living cell,” the company says.
The new randomized, double-blind, placebo-controlled, parallel-arm study1 published in Scientific Reports explored the safety of chronic Niagen supplementation as well as the level of dosing required to sustainably increase blood NAD+ levels. The eight-week study, conducted in 132 healthy overweight adults, is the largest trial conducted on Niagen to date and the first to “measure kinetic and dose-dependent effects of chronic NR supplementation” and demonstrate “safety and optimal dosing levels critical for validation in ongoing research,” ChromaDex said in a press release.
In the study, subjects were given either placebo, 100 mg, 300 mg, or 1000 mg of Niagen NR daily for eight weeks. According to researchers: “Consumption of 100, 300, and 1000 mg [of] NR dose-dependently and significantly increased whole blood NAD+ (i.e., 22%, 51%, and 142%) and other NAD+ metabolites within two weeks. The increases were maintained throughout the remainder of the study. There were no reports of flushing and no significant differences in adverse events between the NR and placebo-treated groups or between groups at different NR doses. NR also did not elevate low-density lipoprotein cholesterol or dysregulate 1-carbon metabolism.”
The researchers said the data in the study support establishing a tolerable upper intake limit for Niagen NR. “Here," the wrote, "we show that once-a-day doses of NR up to 1 gram per day are safe and orally available.”
http://www.nutritionaloutlook.com/scien ... mal-dosing
The new randomized, double-blind, placebo-controlled, parallel-arm study1 published in Scientific Reports explored the safety of chronic Niagen supplementation as well as the level of dosing required to sustainably increase blood NAD+ levels. The eight-week study, conducted in 132 healthy overweight adults, is the largest trial conducted on Niagen to date and the first to “measure kinetic and dose-dependent effects of chronic NR supplementation” and demonstrate “safety and optimal dosing levels critical for validation in ongoing research,” ChromaDex said in a press release.
In the study, subjects were given either placebo, 100 mg, 300 mg, or 1000 mg of Niagen NR daily for eight weeks. According to researchers: “Consumption of 100, 300, and 1000 mg [of] NR dose-dependently and significantly increased whole blood NAD+ (i.e., 22%, 51%, and 142%) and other NAD+ metabolites within two weeks. The increases were maintained throughout the remainder of the study. There were no reports of flushing and no significant differences in adverse events between the NR and placebo-treated groups or between groups at different NR doses. NR also did not elevate low-density lipoprotein cholesterol or dysregulate 1-carbon metabolism.”
The researchers said the data in the study support establishing a tolerable upper intake limit for Niagen NR. “Here," the wrote, "we show that once-a-day doses of NR up to 1 gram per day are safe and orally available.”
http://www.nutritionaloutlook.com/scien ... mal-dosing