NR ⇒ Clinical study affirms Niagen nicotinamide riboside ingredient’s long-term safety, optimal dosing

[guest2701]

ChromaDex (Los Angeles) announced a recently published clinical study affirming the safe use of the company’s Niagen nicotinamide riboside (NR) ingredient. NR is a member of the vitamin B3 family and plays a role in the production of nicotinamide adenine dinucleotide (NAD+), “an essential molecule found in every living cell,” the company says.

The new randomized, double-blind, placebo-controlled, parallel-arm study1 published in Scientific Reports explored the safety of chronic Niagen supplementation as well as the level of dosing required to sustainably increase blood NAD+ levels. The eight-week study, conducted in 132 healthy overweight adults, is the largest trial conducted on Niagen to date and the first to “measure kinetic and dose-dependent effects of chronic NR supplementation” and demonstrate “safety and optimal dosing levels critical for validation in ongoing research,” ChromaDex said in a press release.

In the study, subjects were given either placebo, 100 mg, 300 mg, or 1000 mg of Niagen NR daily for eight weeks. According to researchers: “Consumption of 100, 300, and 1000 mg [of] NR dose-dependently and significantly increased whole blood NAD+ (i.e., 22%, 51%, and 142%) and other NAD+ metabolites within two weeks. The increases were maintained throughout the remainder of the study. There were no reports of flushing and no significant differences in adverse events between the NR and placebo-treated groups or between groups at different NR doses. NR also did not elevate low-density lipoprotein cholesterol or dysregulate 1-carbon metabolism.”

The researchers said the data in the study support establishing a tolerable upper intake limit for Niagen NR. “Here," the wrote, "we show that once-a-day doses of NR up to 1 gram per day are safe and orally available.”

http://www.nutritionaloutlook.com/scien ... mal-dosing

[PaulN]

NR was my introductory molecule into the longevity world and I rapidly felt very good on it, with increased energy and better sleep. I then started using NMN ( 500 mg daily) and decided to keep using the NR as well but at half the dose ( 300 mg per day instead of 600mg). My rationale was a Japanese study I found that showed some overlap between the 2 molecules ( that is, they both did a lot of the same things but also had some separate benefits). Hence for me it was about maximising increased NAD uptake. I also added the NAD+ nasal spray and to be frank, I feel the nasal spray does result in clearer cognition. It will be nice when we finally have some human trial data on the NMN and the NAD+ nasal spray.

[Longevity36]

This is an Interesting take. (Using both NR and NMN). I have both but I currently use 1 at a time. Either NR OR NMN but not both simultaneously. NR enters cells and converts into NMN. NMN has to reportedly convert into Nr to enter the cell and then convert back to NMN. Using both simultaneously is an interesting take .

[Vandevalk1]

This is an Interesting take. (Using both NR and NMN). I have both but I currently use 1 at a time. Either NR OR NMN but not both simultaneously. NR enters cells and converts into NMN. NMN has to reportedly convert into Nr to enter the cell and then convert back to NMN. Using both simultaneously is an interesting take .

I was under the assumption that NMN (a much smaller molecule than NR) enters the cell wall with ease and is therefor more efficient than NR...

[Longevity36]

No. I read somewhere the opposite. NMN is a larger molecule. It has been compared to brick dust!

[AlbertY]

No. I read somewhere the opposite. NMN is a larger molecule. It has been compared to brick dust!

There is a paper on nature metabolism this year shows that NMN can be transported into the cell through a transporter Slc12a8.

Check this "Slc12a8 is a nicotinamide mononucleotide transporter": https://doi.org/10.1038/s42255-018-0009-4

[Drdavid]

Thank you for the article. This is fascinating that there is a NMN transporter and that it allows quick uptake.

[Longevity36]

Exactly. It is a molecule that takes NMN into the cell. That doesn’t make NMN smaller than NR. NR I believe is smaller . NMN just has a connection. A friend who escorts him in the club. NR moves in and out on it’s own.

[Vandevalk1]

So why do we pay more for the "highly sought after" NMN if NR can enter the cell wall all on its own?

[Longevity36]

Good question. I think it’s because of who endorses which. The discoverer of resveratrol benefits and leading face of anti-aging , whether wanting to be or not, push’s NMN. Maybe because of proprietary reasons? NR is being fought for in court and NMN isn’t? The ultimate goal is NMN which increases NAD . . NR is NR that turns to NMN that turns to NAD. So there’s more steps? I’m curious about cutting to the chase and just taking NAD.