NAD+ ⇒ NAD+ and Alzheimer’s Disease

[Drdavid]

NAD+ supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency
Yujun Hou, Sofie Lautrup, Stephanie Cordonnier, Yue Wang, Deborah L. Croteau, Eduardo Zavala, Yongqing Zhang, Kanako Moritoh, Jennifer F. O’Connell, Beverly A. Baptiste, Tinna V. Stevnsner, Mark P. Mattson, and Vilhelm A. Bohr
PNAS February 20, 2018 115 (8) E1876-E1885; first published February 5, 2018 https://doi.org/10.1073/pnas.1718819115

Could mice with Alzheimer’s disease introduced DNA repair deficiency, signs of neuroinflammation, decreased synaptic transmission and phosphorylated Tau pathologies improve with supplementation of Nicotinamide Riboside? The researchers saw that by supplementing with Nicotinamide Riboside there was a decrease in neuroinflammation, improved synaptic transmission and normalized DNA damage. The mice that were supplemented with Nicotinamide Riboside also showed improved memory, learning and motor function. These findings led the researchers to believe that NAD+ supplementation has therapeutic implications for humans with Alzheimer’s disease.

This article can be seen herehttps://www.pnas.org/content/115/8/E1876.short

[p75213]

What would be the most effective NAD+ supplement for treating alzheimer's - sublingual powder/tablets or nasal spray?

[Drdavid]

What would be the most effective NAD+ supplement for treating alzheimer's - sublingual powder/tablets or nasal spray?

I dont know that we have an answer for this yet. Currently the research has just begun to be deciphered and there are very few clinicians actually working with these products especially in the Alzheimer subset. I think anyone of these products would be beneficial but I recommend that a patient with neurodegenerative disease begin with the nasal spray and then add either the tablets or powder to increase dose.
Here is an article that was just published this year that you might find interesting

IUBMB Life. 2019 May; 71(5): 565–579.
Published online 2019 Jan 9. doi: 10.1002/iub.1997
PMCID: PMC6850382
PMID: 30624851
The “great” controlling nucleotide coenzymes
Richard L. Veech,corresponding author 1 Michael Todd King, 1 Robert Pawlosky, 1 Yoshihiro Kashiwaya, 2 Patrick C. Bradshaw, 3 and William Curtis 3
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6850382/

[Fred]

Here is an article that was just published this year that you might find interesting

IUBMB Life. 2019 May; 71(5): 565–579.
Published online 2019 Jan 9. doi: 10.1002/iub.1997
PMCID: PMC6850382
PMID: 30624851
The “great” controlling nucleotide coenzymes
Richard L. Veech,corresponding author 1 Michael Todd King, 1 Robert Pawlosky, 1 Yoshihiro Kashiwaya, 2 Patrick C. Bradshaw, 3 and William Curtis 3
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6850382/

Thank you David. Great article.

[Drdavid]

Another positive research study on the effect of NR on alzheimer's:

NR lessened pTau pathology in both 3xTgAD and 3xTgAD/Polβ+/- mice

NR-treated 3xTgAD/Polβ+/- mice exhibited reduced DNA damage, neuroinflammation, and apoptosis of hippocampal neurons and increased activity of SIRT3 in the brain. NR improved cognitive function in multiple behavioral tests and restored hippocampal synaptic plasticity in 3xTgAD mice and 3xTgAD/Polβ+/- mice


Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):E1876-E1885. doi: 10.1073/pnas.1718819115. Epub 2018 Feb 5.
NAD+ supplementation normalizes key Alzheimer's features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency.
Hou Y1, Lautrup S1,2, Cordonnier S1, Wang Y3, Croteau DL1, Zavala E1, Zhang Y4, Moritoh K5, O'Connell JF6, Baptiste BA1, Stevnsner TV2, Mattson MP3,7, Bohr VA8,9.

https://www.ncbi.nlm.nih.gov/pubmed/29432159

[p75213]

My mother, who has late stage Alzheimer's has had fantastic results using NAD+ nasal spray, Nuchido's Time+ and ashwagandha. The ashwagandha has been included for its ability to reduce cortisol. It took about 6 or 7 weeks to notice anything. The nurses can't believe it. Her symptoms have been reversed 7 or 8 months. I don't know how far she can go with this but she is still improving.

[Drdavid]

My mother, who has late stage Alzheimer's has had fantastic results using NAD+ nasal spray, Nuchido's Time+ and ashwagandha. The ashwagandha has been included for its ability to reduce cortisol. It took about 6 or 7 weeks to notice anything. The nurses can't believe it. Her symptoms have been reversed 7 or 8 months. I don't know how far she can go with this but she is still improving.

It is wonderful to hear this news and how NAD and other natural products have helped your mom. How much time has she been on the product and how many mg per day are you using to achieve these results?

[p75213]

She has been taking the nad+ nasal spray about 10 weeks and the time+ and ashwagandha about 8 weeks. The abn NAD+ nasal spray she has 4 squirts up each nostril per day. The time+ is the standard dose of 3 capsules twice a day taken 6 hours apart. The ashwagandha 6 g twice a day.
My mother will be 94 yo at the end of this month.

[drkris69]

Wow thats awesome news p75213. Thanks for sharing your Mother's condition and her positive response to NAD+. I hope others out there will read this and follow suit.

[p75213]

Wow thats awesome news p75213. Thanks for sharing your Mother's condition and her positive response to NAD+. I hope others out there will read this and follow suit.

It would be good to see if others have a similar response. I know the Vancouver Dementia Centre uses NAD+ in a nebuliser.