No worries if you don´t, it´s summarized right here:
https://hms.harvard.edu/news/rewinding-clockThe team gave NMN over two months to a group of mice that were 20 months old—the rough equivalent of 70 in human years. NMN treatment restored the number of blood capillaries and capillary density to those seen in younger mice. Blood flow to the muscles also increased and was significantly higher than blood supply to the muscles seen in same-age mice that didn’t receive NMN.
The most striking effect, however, emerged in the aging mice’s ability to exercise. These animals showed between 56 and 80 percent greater exercise capacity, compared with untreated mice the study showed. The NMN-treated animals managed to run 430 meters, or about 1,400 feet, on average, compared with 240 meters, or 780 feet, on average, for their untreated peers.
This NEW study in humans, "Low skeletal muscle capillarization limits muscle adaptation to resistance exercise training in older adults",
didn´t involve any supplementation but it may be important for future studies into NMN or other NAD precursors to try and increase muscle capillarization in humans, not just in mice. It would have been great if another arm in this study in addition to the 12-weeks of resistance training also took 1000 mg of NMN.
https://www.sciencedirect.com/science/a ... via%3DihubObjectives
Adequate muscle perfusion supports the transport of nutrients, oxygen and hormones into muscle fibers. Aging is associated with a substantial decrease in skeletal muscle capillarization, fiber size and oxidative capacity, which may be improved with regular physical activity.
The aim of this study was to investigate the relationship between muscle capillarization and indices of muscle hypertrophy (i.e. lean mass; fiber cross sectional area (CSA)) in older adults before and after 12 weeks of progressive resistance exercise training (RET).
Conclusions
Muscle fiber capillarization before starting an exercise training program may be predictive of the muscle hypertrophic response to resistance exercise training (RET) in older adults. Increases in muscle fiber size following RET appear to be blunted when muscle capillarization is low, suggesting that an adequate initial capillarization is critical to achieving a meaningful degree of muscle adaptation to RET.