NAD+ Forums

Posted: **Fri Jan 03, 2020 10:39 pm**

According to Sinclair, you'll want to use Trans-Reveratrol as it is a better form and you'll want to take it with yogurt. Something about the fat in yogurt that helps it absorb into the system better.

As far as brand, I use "We Like Vitamins" Trans-Reveratrol on Amazon. Tons of great reviews and is also the best price I have found yet. I take one 1,000 mg capsule per day with yogurt. Hope this helps.

https://www.amazon.com/gp/aw/d/B01I1YI0 ... asin_title

Posted: **Sat Jan 04, 2020 7:54 pm**

Here is an article that I hope anyone taking Resveratrol will read:

Biomedicines. 2018 Sep; 6(3): 91.
Published online 2018 Sep 9. doi: 10.3390/biomedicines6030091
PMCID: PMC6164842
PMID: 30205595
Resveratrol: A Double-Edged Sword in Health Benefits
Bahare Salehi,1,2 Abhay Prakash Mishra,3 Manisha Nigam,4 Bilge Sener,5 Mehtap Kilic,5 Mehdi Sharifi-Rad,6,* Patrick Valere Tsouh Fokou,7,* Natália Martins,8,9,* and Javad Sharifi-Rad10,11,*

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164842/

Posted: **Sun Jan 05, 2020 2:24 am**

Drdavid wrote: ↑Sat Jan 04, 2020 7:54 pm Here is an article that I hope anyone taking Resveratrol will read:

Biomedicines. 2018 Sep; 6(3): 91.
Published online 2018 Sep 9. doi: 10.3390/biomedicines6030091
PMCID: PMC6164842
PMID: 30205595
Resveratrol: A Double-Edged Sword in Health Benefits
Bahare Salehi,1,2 Abhay Prakash Mishra,3 Manisha Nigam,4 Bilge Sener,5 Mehtap Kilic,5 Mehdi Sharifi-Rad,6,* Patrick Valere Tsouh Fokou,7,* Natália Martins,8,9,* and Javad Sharifi-Rad10,11,*

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164842/

Thank you David. A good read. I remember reading it when it came out but reading it again now as I´m thinking of ordering micronized trans-resveratrol from Megaresveratrol (used in several human clinical studies). It seems that the salutary effects on metabolic syndrome appear when reaching a dose of at least 500 mg. Reading the literature a dose of 500-1000 mg seems to have some effects in humans on cerebral blood flow, glucose and inflammation.

I still haven´t found conclusive data on dosing with regards to one dose per 24 h with food as Dr. Sinclair is doing or twice a day dosing with meals. Anyone knows of a paper arguing one way or the other with regards to pharmacokinetics and time of dosing?

Posted: **Mon Jan 06, 2020 2:39 pm**

Thanks DrDavid I just read your post and the article. Thanks for the info.

Posted: **Tue Jan 07, 2020 11:46 am**

Drdavid wrote: ↑Sat Jan 04, 2020 7:54 pm Here is an article that I hope anyone taking Resveratrol will read:

Biomedicines. 2018 Sep; 6(3): 91.
Published online 2018 Sep 9. doi: 10.3390/biomedicines6030091
PMCID: PMC6164842
PMID: 30205595
Resveratrol: A Double-Edged Sword in Health Benefits
Bahare Salehi,1,2 Abhay Prakash Mishra,3 Manisha Nigam,4 Bilge Sener,5 Mehtap Kilic,5 Mehdi Sharifi-Rad,6,* Patrick Valere Tsouh Fokou,7,* Natália Martins,8,9,* and Javad Sharifi-Rad10,11,*

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164842/

Thanks Drdavid
Your science based article attachments are always beneficial to the topic under discussion.

Posted: **Tue Jan 07, 2020 12:19 pm**

Drdavid.
You attach the articles to your post and then
“walk away, so to speak” which allows the forum member to choose to read the article and then form their own opinion. The proper procedure in my view.
Thanks again.

Posted: **Tue Jan 07, 2020 5:27 pm**

Drdavid wrote: ↑Sat Jan 04, 2020 7:54 pm Here is an article that I hope anyone taking Resveratrol will read:

Biomedicines. 2018 Sep; 6(3): 91.
Published online 2018 Sep 9. doi: 10.3390/biomedicines6030091
PMCID: PMC6164842
PMID: 30205595
Resveratrol: A Double-Edged Sword in Health Benefits
Bahare Salehi,1,2 Abhay Prakash Mishra,3 Manisha Nigam,4 Bilge Sener,5 Mehtap Kilic,5 Mehdi Sharifi-Rad,6,* Patrick Valere Tsouh Fokou,7,* Natália Martins,8,9,* and Javad Sharifi-Rad10,11,*

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164842/

Hey David, useful article

Firstly happy new year to you - could you get back to me re: previous post

Posted: **Wed Jan 08, 2020 6:59 am**

Fred wrote: ↑Sun Jan 05, 2020 2:24 am
Drdavid wrote: ↑Sat Jan 04, 2020 7:54 pm Here is an article that I hope anyone taking Resveratrol will read:

Biomedicines. 2018 Sep; 6(3): 91.
Published online 2018 Sep 9. doi: 10.3390/biomedicines6030091
PMCID: PMC6164842
PMID: 30205595
Resveratrol: A Double-Edged Sword in Health Benefits
Bahare Salehi,1,2 Abhay Prakash Mishra,3 Manisha Nigam,4 Bilge Sener,5 Mehtap Kilic,5 Mehdi Sharifi-Rad,6,* Patrick Valere Tsouh Fokou,7,* Natália Martins,8,9,* and Javad Sharifi-Rad10,11,*

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164842/
Thank you David. A good read. I remember reading it when it came out but reading it again now as I´m thinking of ordering micronized trans-resveratrol from Megaresveratrol (used in several human clinical studies). It seems that the salutary effects on metabolic syndrome appear when reaching a dose of at least 500 mg. Reading the literature a dose of 500-1000 mg seems to have some effects in humans on cerebral blood flow, glucose and inflammation.

I still haven´t found conclusive data on dosing with regards to one dose per 24 h with food as Dr. Sinclair is doing or twice a day dosing with meals. Anyone knows of a paper arguing one way or the other with regards to pharmacokinetics and time of dosing?

Fred,
I use the micronized transresveratrol and have been happy. I have not found any conclusive data on the one dose with food either. I think that Dr. Sinclair is on the leading edge of his field and sometimes uses his personal responses and regimens as scientific fact. If you find any data I would appreciate seeing it.

Posted: **Wed Jan 08, 2020 10:53 am**

Drdavid wrote: ↑Wed Jan 08, 2020 6:59 am
Fred wrote: ↑Sun Jan 05, 2020 2:24 am I still haven´t found conclusive data on dosing with regards to one dose per 24 h with food as Dr. Sinclair is doing or twice a day dosing with meals. Anyone knows of a paper arguing one way or the other with regards to pharmacokinetics and time of dosing?
Fred,
I use the micronized transresveratrol and have been happy. I have not found any conclusive data on the one dose with food either. I think that Dr. Sinclair is on the leading edge of his field and sometimes uses his personal responses and regimens as scientific fact. If you find any data I would appreciate seeing it.

Sure, I´ll do. Since 1000 mg twice a day has been tested in absorption studies I´m thinking we don´t have to split a 1 g dose into two 0.5 g doses unless GI distress occurs (the most common side effect of resveratrol).

Posted: **Wed Jan 08, 2020 1:45 pm**

Fred wrote: ↑Sun Jan 05, 2020 2:24 am
Drdavid wrote: ↑Sat Jan 04, 2020 7:54 pm Here is an article that I hope anyone taking Resveratrol will read:

Biomedicines. 2018 Sep; 6(3): 91.
Published online 2018 Sep 9. doi: 10.3390/biomedicines6030091
PMCID: PMC6164842
PMID: 30205595
Resveratrol: A Double-Edged Sword in Health Benefits
Bahare Salehi,1,2 Abhay Prakash Mishra,3 Manisha Nigam,4 Bilge Sener,5 Mehtap Kilic,5 Mehdi Sharifi-Rad,6,* Patrick Valere Tsouh Fokou,7,* Natália Martins,8,9,* and Javad Sharifi-Rad10,11,*

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164842/
Thank you David. A good read. I remember reading it when it came out but reading it again now as I´m thinking of ordering micronized trans-resveratrol from Megaresveratrol (used in several human clinical studies). It seems that the salutary effects on metabolic syndrome appear when reaching a dose of at least 500 mg. Reading the literature a dose of 500-1000 mg seems to have some effects in humans on cerebral blood flow, glucose and inflammation.

I still haven´t found conclusive data on dosing with regards to one dose per 24 h with food as Dr. Sinclair is doing or twice a day dosing with meals. Anyone knows of a paper arguing one way or the other with regards to pharmacokinetics and time of dosing?

Hey Fred. Thanks for pointing them out. They have test results showing purity but do not mention any heavy metal content.

I asked Bulk Supplements for their testing documentation and this is what they sent. I think I would like to do the tablet way for now and see how these things pan out. I am on NR from TruNiagen but think I am going to switch over to NMN and add TransReservatrol from MegaReservatrol or AliveByNature. Both sell it. I am suprised that I have not seen their documentation on their products on this forum.

Here is their report from my Drive: https://drive.google.com/open?id=0B_EgW ... VqOHNYTlRR

I agree with most, we need a recommendation for NMN and Reservatrol from a company that will provide test results for both products.

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