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NR and NR Chloride

Posted: Wed Oct 09, 2019 6:33 pm
by p75213
In addition to nicotinamide riboside there is also nicotinamide riboside chloride. Which one does everyone take and why? Does it really matter?

Re: NR and NR Chloride

Posted: Wed Oct 09, 2019 6:41 pm
by Fred
The chloride salt is bound to NR to stabilise it. The tradename "Niagen" is the chloride form and was first to market.

Re: NR and NR Chloride

Posted: Thu Oct 10, 2019 12:46 am
by p75213
So all the NR that is sold as a supplement is in fact NR chloride? Some brands don't specifically say niagen or NR chloride. Just NR.

Re: NR and NR Chloride

Posted: Thu Oct 10, 2019 1:27 am
by Fred
Elysium used Niagen from the beginning. Now the source or form of NR in Elysium's Basis is unknown. True Niagen, Thorne and LEF use Niagen.

Re: NR and NR Chloride

Posted: Thu Oct 24, 2019 5:17 pm
by ChrisBON
Fred wrote: Thu Oct 10, 2019 1:27 am Elysium used Niagen from the beginning. Now the source or form of NR in Elysium's Basis is unknown. True Niagen, Thorne and LEF use Niagen.
So if i am taking NMN sl and NAD+ as well as Astaxanthin and Blueberry Concentrate, is NR really necessary?

Re: NR and NR Chloride

Posted: Thu Oct 24, 2019 5:53 pm
by Fred
The difference in pharmacokinetics and target tissues between NR and NMN in humans is currently unknown (we have to wait for human NMN data to be published).

They are similar molecules. NMN is NR with a phosphate group attached (which makes it more stable in solution). NR converts to NMN inside the cell and NMN can convert to NR outside the cell. Both have produced positive effects in animal trials.

There have been no published animal experiments using the two together so we don't know if there's any synergistic effect.

Re: NR and NR Chloride

Posted: Fri Oct 25, 2019 9:49 am
by Vandevalk1
Thanks Fred. Very interesting!

Re: NR and NR Chloride

Posted: Sat Oct 26, 2019 3:49 pm
by ChrisBON
Thanks Fred
I appreciate it!

Re: NR and NR Chloride

Posted: Sun Oct 27, 2019 2:08 pm
by canadahealthy
ChrisBON wrote: Thu Oct 24, 2019 5:17 pm
Fred wrote: Thu Oct 10, 2019 1:27 am Elysium used Niagen from the beginning. Now the source or form of NR in Elysium's Basis is unknown. True Niagen, Thorne and LEF use Niagen.
So if i am taking NMN sl and NAD+ as well as Astaxanthin and Blueberry Concentrate, is NR really necessary?
i think NR is another way of elevating NAD+ and there is some arguing as to whether it is as effective or even more effective than NMN. However, the leading researcher, Dr David Sinclair, insists NMN is the most reliable method.

I think with all you are taking that you do not need NR.

Re: NR and NR Chloride

Posted: Thu Oct 31, 2019 4:42 pm
by smokinjoe
canadahealthy wrote: Sun Oct 27, 2019 2:08 pm
ChrisBON wrote: Thu Oct 24, 2019 5:17 pm
Fred wrote: Thu Oct 10, 2019 1:27 am Elysium used Niagen from the beginning. Now the source or form of NR in Elysium's Basis is unknown. True Niagen, Thorne and LEF use Niagen.
So if i am taking NMN sl and NAD+ as well as Astaxanthin and Blueberry Concentrate, is NR really necessary?
i think NR is another way of elevating NAD+ and there is some arguing as to whether it is as effective or even more effective than NMN. However, the leading researcher, Dr David Sinclair, insists NMN is the most reliable method.

I think with all you are taking that you do not need NR.
I think ChrisBON is taking the stuff I need to take.