NAD+ Forums

Another scientific study demonstrates the importance of maintaining high levels of coenzyme NAD+ for the prevention of neurodegenerative disorders

NAD+ in Brain Aging and Neurodegenerative Disorders
Sofie Lautrup, David A. Sinclair, Mark P. Mattson, Evandro F. Fang
Cell Metabolism - Volume 30, Issue 4, 1 October 2019, Pages 630-655

NAD+ is a pivotal metabolite involved in cellular bioenergetics, genomic stability, mitochondrial homeostasis, adaptive stress responses, and cell survival. Multiple NAD+-dependent enzymes are involved in synaptic plasticity and neuronal stress resistance. Here, we review emerging findings that reveal key roles for NAD+ and related metabolites in the adaptation of neurons to a wide range of physiological stressors and in counteracting processes in neurodegenerative diseases, such as those occurring in Alzheimer’s, Parkinson’s, and Huntington diseases, and amyotrophic lateral sclerosis. Advances in understanding the molecular and cellular mechanisms of NAD+-based neuronal resilience will lead to novel approaches for facilitating healthy brain aging and for the treatment of a range of neurological disorders.

Link to the study:
https://www.sciencedirect.com/science/a ... JISGgLbFeE

Great post David Dean.

daviddean wrote: ↑Tue Oct 15, 2019 5:05 am Another scientific study demonstrates the importance of maintaining high levels of coenzyme NAD+ for the prevention of neurodegenerative disorders

NAD+ in Brain Aging and Neurodegenerative Disorders
Sofie Lautrup, David A. Sinclair, Mark P. Mattson, Evandro F. Fang
Cell Metabolism - Volume 30, Issue 4, 1 October 2019, Pages 630-655

NAD+ is a pivotal metabolite involved in cellular bioenergetics, genomic stability, mitochondrial homeostasis, adaptive stress responses, and cell survival. Multiple NAD+-dependent enzymes are involved in synaptic plasticity and neuronal stress resistance. Here, we review emerging findings that reveal key roles for NAD+ and related metabolites in the adaptation of neurons to a wide range of physiological stressors and in counteracting processes in neurodegenerative diseases, such as those occurring in Alzheimer’s, Parkinson’s, and Huntington diseases, and amyotrophic lateral sclerosis. Advances in understanding the molecular and cellular mechanisms of NAD+-based neuronal resilience will lead to novel approaches for facilitating healthy brain aging and for the treatment of a range of neurological disorders.

Link to the study:
https://www.sciencedirect.com/science/a ... JISGgLbFeE

Anything that could help with neurodegenerative disease would be wonderful. Our current medical set of protocols provides very little relief for the patient or the family. NAD seems to be something that could help this large patient population.

Also Diet and fasting could have a great impact on neurodegenerative disorsers. Alzheimer is increasingly considered a type c diabetes.

I suggest the reading of this book: an approach to healing chronic autoimmune conditions by a doctor, researcher, and sufferer of progressive multiple sclerosis (MS).
www.amazon.com/Wahls-Protocol-Autoimmun ... 1583335544

David

Physical energy and stamina is but one small and literal expression of ATP energy that results from ATP production. “Energy” is used for every function of the body; from a heartbeat to replication of a healthy cell to liver detoxification to hair growth to ... well, you get the idea. It’s everything, everywhere, all the time, in every function.Excessive amounts of these free radicals can lead to cell injury and death, resulting in diseases such as cancer, stroke, fibromyalgia, hypertension, metabolic syndrome,hormonal resistance, weight gain, myocardial infarction, diabetes and other major
disorders.Current scientific breakthroughs tell us the theory of mitochondrial decline is that, “without adequate energy, the body is unable to control the free radicals andthus become damaged by its own metabolic by‐products.”WITHOUT ADEQUATE ENERGY, THE BODY CANNOT ELIMINATE FREE
RADICALS FROM THE CELL. THIS IS CALLED INFLAMMATION.!!!
Mitochondria render energy for every cellular function including the repair of the genetic code so the cells replicate themselves with minimal damage from aging. For a human being, there is an optimal range of active, energy‐producing mitochondria that are associated with optimal health. Most people today are suffering from a lack of energy, especially cellular energy, indicating there are rampant mitochondrial and cell membrane disruptor issues. This is why NMN and NAD+ are so important for keeping Mitochondria healthy.

Has anyone found threads on other boards (perhaps about Alzheimer’s or ALS about people experimenting with nad precursors?

Those are the more difficult cases, anything dealing with the brain in general, is going to be longer and drawn out as far as treating them. We can only assume that NAD+ would benefit these types of patients. I would say that the NAD+ IVs would be the best bet!

rhett wrote: ↑Wed Oct 16, 2019 11:28 am Has anyone found threads on other boards (perhaps about Alzheimer’s or ALS about people experimenting with nad precursors?

It's hard to know where to post things under sometimes. I posted this study in the LONGEVITY section on the 3rd of October but it didn't lead to any discussion at all lol. I didn't put it in the NAD+ section because that one is about supplementing with the molecule NAD+. Good that the paper is getting discussed now.
viewtopic.php?f=77&t=831

I think a "Brain aging" and "Skin and hair" section would be a great addition to the forum. We could have put this in the "Brain aging"-section.

Ah that makes sense. I’m wondering more if there are other forums out there on the Internet aside from Alive yNature, maybe ones that are created for Alzheimer’s it ALS patients where they talk about rheir conditions and share info about treatments. It’s possible that they’re already trying and discussing NMN within their online community. Would be super interesting to find them if so.

rhett wrote: ↑Thu Oct 17, 2019 9:50 pm Ah that makes sense. I’m wondering more if there are other forums out there on the Internet aside from Alive yNature, maybe ones that are created for Alzheimer’s it ALS patients where they talk about rheir conditions and share info about treatments. It’s possible that they’re already trying and discussing NMN within their online community. Would be super interesting to find them if so.

it might just be an issue of awareness at this point. many promising Alzheimer's treatments such as Aricept, for example haven't produced the results that had been expected.