Why NAD+ Matters
Regulates Cellular Metabolism
NAD+ is a substrate for enzymes like sirtuins, which regulate DNA repair, gene expression, mitochondrial function, and cellular stress responses. It ensures efficient metabolic function and supports cellular repair to help every cell in your body work together so you feel your best.
Promotes DNA Repair
NAD+ is indispensable for enzymes like PARPs (poly(ADP-ribose) polymerases), which repair damaged DNA and protect genomic stability. This supports healthy aging and safeguards your body from the cumulative effects of cellular stress.
Boosts Energy Levels
Mitochondria rely on a constant level of NAD+ to produce ATP, the energy currency of your cells. By replenishing NAD+ levels, NR ensures sustained energy output, delaying fatigue and promoting metabolic efficiency.
Supports Epigenetic Health
Through its interaction with sirtuins, NAD+ influences gene expression, regulating pathways associated with stress resilience, tissue healing, and longevity. This epigenetic regulation helps preserve cellular function as we age.
Why Choose Nicotinamide Riboside (NR)?
Nicotinamide Riboside (NR) is a scientifically validated NAD+ precursor that offers a direct, efficient way to replenish declining NAD+ levels and promote cellular health. Here's why it's one of the top choices for enhancing vitality and longevity.
Restores NAD+ Levels Efficiently
NR is a form of vitamin B3 that your body naturally converts into NAD+ using the Preiss-Handler pathway. This process makes NR a reliable and direct method for restoring NAD+, a coenzyme essential for energy production, DNA repair, and healthy cellular function.
Think of NAD+ as the fuel that powers nearly every cell in your body. Over time, aging and stress deplete NAD+ reserves, leading to lower energy, slower repair processes, and reduced resilience to stress. By taking NR, you provide your cells with the materials they need to replenish their NAD+ supply, helping them work more efficiently.
Mechanistically, NR is absorbed into cells where enzymes, such as NR kinases, convert it via an intermediate step on the way to NAD+ synthesis. Once NAD+ is produced, it fuels vital processes such as mitochondrial energy production and the activation of repair enzymes like sirtuins and PARPs.
NR Supports Cellular Repair and Maintenance
When NAD+ levels are restored, the entire cellular repair network becomes more active. NAD+ fuels sirtuins, enzymes that regulate cellular repair and metabolism, helping to maintain genetic stability and protect against the damage caused by oxidative stress.
This means that with NR supplementation, you may feel more energized and notice improvements in overall health. Over time, the effects of sustained NAD+ levels include faster recovery from stress, increased mental clarity, and a renewed sense of optimism and motivation.
At the cellular level, NAD+ also drives DNA repair through enzymes like poly(ADP-ribose) polymerases (PARPs). These enzymes fix breaks in DNA strands caused by everyday wear and tear or exposure to environmental toxins, preserving the integrity of your genetic code.
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Scientifically Validated
Nicotinamide Riboside (NR) is one of the most extensively studied precursors to NAD+, with a growing body of clinical and preclinical research demonstrating its efficacy and safety. These studies validate the transformative potential of NR in restoring NAD+ levels and supporting cellular
health, making it a foundational step in your longevity strategy.
Proven to Raise NAD+ Levels
Human trials consistently show that NR supplementation effectively increases NAD+ levels in a safe and sustained manner.
A landmark study published in Nature Communications demonstrated that NR supplementation increased NAD+ levels by 60% in healthy middle-aged and older adults over eight weeks, with no significant side effects reported. This highlights NR's suitability for long-term use. (1)
Another trial in Cell Metabolism confirmed similar NAD+ elevations in individuals supplemented with NR, emphasizing its ability to promote energy metabolism and cellular repair. (2)
Benefits for Mitochondrial Health
Mitochondrial function is essential for energy production and metabolic health, yet it declines with age. NR supplementation has been shown to restore mitochondrial efficiency by replenishing NAD+, a critical coenzyme for energy metabolism.
Animal studies published in Science found that boosting NAD+ levels with NR improved mitochondrial function and physical endurance in aged mice, highlighting its role in combating age-related energy decline. (3)
Research in Nature Communications further demonstrated that NR supplementation enhanced mitochondrial biogenesis—the process by which cells generate new mitochondria—leading to improved metabolic flexibility and energy output. (4)
Supports Metabolic Health and Insulin Sensitivity
NR has been studied for its effects on metabolic health, particularly its ability to protect insulin sensitivity and support glucose regulation.
A study in Scientific Reports reported that NR supplementation improved insulin sensitivity and reduced liver fat accumulation in prediabetic mice, suggesting potential benefits for managing metabolic disorders. (5)
Slowing Age-Related Decline
Emerging research highlights NR’s potential to mitigate age-related conditions by promoting cellular repair and reducing oxidative stress:
DNA Repair: Studies have shown that NAD+ levels are essential for DNA repair mechanisms. By raising NAD+, NR activates enzymes like PARPs that fix damaged DNA, preserving genomic stability. (6)
Oxidative Stress Reduction: Research in Aging Cell demonstrated that NR supplementation reduced markers of oxidative stress in aged cells, protecting against cellular damage. (7)
Practical and Safe for Long-Term Use
NR is not only effective but also safe. Clinical trials have consistently reported no significant adverse effects, even with prolonged supplementation at therapeutic doses. This makes NR a practical and reliable option for anyone seeking to enhance their healthspan and energy levels as they age.
With robust scientific backing, NR stands out as a validated solution for restoring NAD+ levels, protecting cellular function, and promoting overall vitality. These findings make it an essential choice for those looking to take proactive control of their long-term health.
