Intranasal delivery of NAD+, NMN and NR
Intranasal delivery is the quickest, most efficient way to deliver NAD+, NMN and NR directly to the brain. It is the best option to bypass the blood-brain barrier, reduce systemic adverse effects of drugs, and to allow a lower dose of drugs to be administered.
Intranasal Delivery Bypasses the Blood/Brain Barrier
The purpose of the blood–brain barrier is to protect against toxins or pathogens circulating in the blood that might cause brain infections, while at the same time allowing vital nutrients to reach the brain.
In a study published in September 2018, administration of LABELED NAD+ by IP and IV injection demonstrated that exogenous NAD+ crosses the blood brain barrier to enter the hypothalamus INTACT, reduces hunger and weight gain, and increases energy expenditure and fat burning in mice.
The study also shows that NR and NMN can not utilize the cd43 gap to cross the blood brain barrier.
"In conclusion, our results demonstrate that exogenous NAD is effectively imported into the hypothalamus and increases hypothalamic NAD content. Therefore, NAD supplement can constitute a therapeutic method for metabolic disorders characterized by hypothalamic NAD depletion in humans."(1)
Intranasal Delivery Reduces Systemic Adverse Effects of Drugs
Because intranasal delivers drugs to a targeted area, it reduces the chances for systemic adverse side effects. Systemic side effects are defined as those effects occurring in tissues distant from the site of contact between the body and the medical device or biomaterial.
"Furthermore, the drugs administered using nasal route have usually higher bioavailability, less side effects and result in higher brain exposure at similar dosage than the oral drugs."(2)
- Exogenous nicotinamide adenine dinucleotide regulates energy metabolism via hypothalamic Connexin 43 (Roh, 2018)
- Evaluation of intranasal delivery route of drug administration for brain targeting
- Intranasal administration with NAD+ profoundly decreases brain injury in a rat model of transient focal ischemia
- Prevention of Traumatic Brain Injury-Induced Neuron Death by Intranasal Delivery of Nicotinamide Adenine Dinucleotide
- Neuronal death induced by misfolded prion protein is due to NAD+ depletion and can be relieved in vitro and in vivo by NAD+ replenishment