1.7 Ounces
Per Bottle
Recommended
2 Pumps
Liposomal
Face Serum
New! Renue Blue™ Face Serum with Methylene Blue, Glutathione, NAD⁺, NMN, NR (Liposomal)
$57.95
Experience the transformative power of the NEW & IMPROVED Renue Blue Face Serum formula delivering TWICE the amount of Methylene Blue, along with liposomal NAD+, NMN, NR, Apocynin, Glutathione and ALA across the layers of the skin using breakthrough nanoliposome technology.
2 mL (2 pumps) provides ▸1.1μm Methylene Blue ▸100 mg NAD⁺ Complex ▸ 5 mg Apocynin ▸1 mg Glutathione
1.7 Ounces
Per Bottle
Recommended
2 Pumps
Liposomal
Face Serum
Renue Blue™ Face Serum
Renue Blue Face Serum works at the cellular level to deliver time-released actives that restore NAD⁺ to improve skin’s texture, firmness, and dermal matrix.
The epitome of science and performance, Renue Blue Face Serum renews cells from within using a proprietary Liposomal Methylene Blue with NAD⁺ Complex (NAD+, NMN, and NR)—science-backed nutrients that provide nourishment on the cellular level.
Renue Blue works at the cellular level to deliver time-released actives that restore NAD⁺ to improve skin’s texture, firmness, and dermal matrix.
Nano-sized liposomes penetrate quickly and deeply into dermal layers to deliver a very high concentration of active ingredients that provide unique therapeutic benefits over all other serums.
Expertly formulated with liposomal NAD⁺ Complex (NAD+, NMN, and NR) and Methylene Blue, along with Apocynin, and Glutathione, this potent delivery system offers a deeper penetration of key ingredients into the skin’s surface to combat the most visible signs of aging and promote vibrant, youthful-looking skin.
Use day and night with Renue Blue Face Creme or Renue Blue Body Lotion. Suitable for all skin types.
METHYLENE BLUE
Methylene Blue has been studied for a wide range of ailments, many of which are aging-related illnesses, and there are currently over 20,000 studies on Pubmed. One study conducted at the University of Maryland tested the potential dermal anti-aging benefits of four antioxidants, one of which was Methylene Blue.
Among all of the antioxidants studied, Methylene Blue was by far, the most effective.
University of Maryland Study
The study was conducted by the Department of Cell Biology & Molecular Genetics, at the University of Maryland.
In the study, researchers tested out four antioxidants on the skin, one of which was Methylene Blue. The second one was N. Acetyl Cysteine, or NAC, a very popular antioxidant, often taken as a supplement. The last two were MitoQ and mTEM - both of which are mitochondrial targeting antioxidants.
They applied each one topically to skin fibroblasts of healthy middle-aged adults, adults 80 and older and from people with progeria.
For most studies, skin fibroblasts are obtained through a non-invasive procedure that involves numbing at the site and taking a punch skin biopsy sample.
Progeria is an extremely rare genetic condition characterized by dramatic and rapid aging. It causes severe hardening of the arteries at a young age, and often those afflicted don't live past their teenage years.
Some researchers believe that Progeria may hold the key to understanding the precise causes of aging - so that it can be slowed down.
For this study, the Progeria fibroblasts were used as an accelerated model for normal aging - because they share many of the features in common with normal aging.
One part of the study looked at the effectiveness of these antioxidants to decrease oxidative stress. Oxidative stress plays a major role in the aging process in the skin, much of which is driven by UV exposure.
Among all of the antioxidants studied, Methylene Blue was the most effective.
It reduced mitochondrial reactive oxygen species, and promoted skin cell proliferation - which involves an increase in the cell division rate and that leads to a higher number of new, healthy cells created during cell turn-over.
The normal skin and the progeria skin treated with the Methylene Blue, showed much higher skin proliferation levels.
Research shows that as a person ages, proliferation of cells in the basal (or deepest) layer reduces. The epidermis (or the outer layer) then becomes thinner. The nutrition supply to the outer layer then weakens because of dysfunction in the deeper layers.
This process of decreased proliferation in the skin, is associated with senescence. Senescent cells, also known as zombie cells, can cause a lot of damage. They are cells that eventually stop multiplying, yet they don't die off like they should. Instead, they remain in the body and continue to release damaging chemicals that trigger inflammation.
In the second part of the study, cellular senescence was examined.
Different fibroblasts were used and treated with Methylene Blue. Two fibroblasts from people over 80 were used and two fibroblasts from people under 30 were used.
The over 80 fibroblasts showed increases in biomarkers of senescence. When treated with Methylene Blue, there was a reduction in cellular senescence, especially notable for the older skin fibroblasts. This showed that Methylene Blue is effective at reducing cellular senescence.
The study revealed that skin treated with Methylene Blue had an increase in skin thickness and improved levels of skin hydration.
This is important because skin thickness and loss of hydration are issues of aging skin. Dermal thickness decreases by about 6% every decade.
Among all of the antioxidants studied, Methylene Blue was the most effective.
The Methylene Blue-treated skin showed a greater reduction in DNA damage, leading to cell rejuvenation.
There was an increase the cell division rate, leading to a higher number of healthy new cells created during cellular turnover.
In addition, there was less senescence - and a slower rate of cell death, indicating that skin cells became healthier and lived longer.
There was also improved hydration levels and dermal thickness was increased.
Study: Anti-Aging Potentials of Methylene Blue for Human Skin Longevity https://www.nature.com/articles/s41598-017-02419-3
Fighting against Skin Aging The Way from Bench to Bedside https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047276/
The evolving role of the NAD+/nicotinamide metabolome in skin homeostasis, cellular bioenergetics, and aging https://sci-hub.do/10.1016/j.dnarep.2014.04.005
NAD in Skin: Therapeutic Approaches for Niacin https://sci-hub.do/10.2174/138161209787185760
Characteristics of the Aging Skin https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840548/
Xiong, ZM, O’Donovan, M., Sun, L., et al. Anti-Aging Potentials of Methylene Blue for Human Skin Longevity. Sci Rep 7, 2475 (2017) (https://doi.org/10.1038/
RENUE™ - 2 Step Skin Rejuvenation Protocol
What's the ideal pH for skin-care products?
You want to look for skin-care products with a pH of 5.5. If anything, they could be as low as 4.5 and as high as 7. The general rule is slightly acidic is preferred for the best complexion.
What pH are Renue™ Products?
Renue™ NAD+ Skincare products are on the optimal 5.5 mark on the pH scale.
High pH (8 to 14)
Skin-care products with a high pH level (also known as alkaline) pose the biggest threat to your skin's pH and acid mantle. That tight, squeaky-clean feeling you might experience after washing your face is the truest sign of cleansers with a high pH and damaged skin barrier. They, as well as other alkaline skin-care products, tend to strip away sebum and natural oils.
Low pH (1 to 6)
Because products with a low pH are at a level closer to skin's natural pH, they will more effectively work with your skin and help cell turnover gently. They're more likely to keep skin bright and smooth, instead of flaky and angry.
However, certain products can be too low of a pH for skin and irritate it. At-home peels and other acid-spiked products tend to have a lower pH level, making them great exfoliants but just as stripping as products with a high pH.
Ingredients
Active Liposomal Ingredients
- Methylene Blue
- NAD+ Complex: Nicotinamide Adenine Dinucleotide (NAD+) · Nicotinamide Mononucleotide (NMN)
- Apocynin
- Glutathione
- Alpha-Lipoic Acid (ALA)
- Hyaluronic Acid (HLA)
Helianthus Annuus (from Sunflower Lecithin) · Glycerin · Aloe Barbadensis (Aloe Vera) · Rosmarinus Officinalis · Chondrus Crispus (Seaweed Extract) · Hyaluronic Acid (HLA) · Alpha-Lipoic Acid (ALA) · Citric Acid
Emollients & Stabilizers
Tocopherols (Vitamin E) · Propylene Glycol · Carbomer · Cetearyl Alcohol · Glycerol Stearate · Triethanolamine · Potassium Sorbate
Resveratrol
“The Longevity Molecule"
Resveratrol is a stilbenoid polyphenol synthesized by plants in response to stressful stimuli and is protective in aging. 9, 10, 6
Its broad-spectrum properties (antimicrobial, anti-inflammatory, antioxidant and anti-aging) make it a potent bioactive for dermatological application by limiting the effects of cellular aging. 11
Its antioxidant activity (95%) is higher than vitamin E (65%) and C (37%) and has been shown to be active in neutralizing and inhibiting the formation of reactive oxygen species. 6, 12
Apocynin
The Skin Cell Tonic”
Apocynin, a natural vanilloid compound, has emerged as a bioactive phytochemical with potent anti-inflammatory properties for the skin. 13
A new paper published in Nature, found that declining levels of a collagen protein called COL17A1 (Collagen 17), cause our skin to develop wrinkles, sag and lose elasticity. 4
Apocynin was able to restore levels of Collagen 17 and repair damaged skin, leading scientists to believe it’s possible to reverse our skin’s timeline at the cellular level. 14
NAD+
"The Youth Molecule"
May Improve Rosacea
According to research Topical NAD+ has been shown to improve metabolism of skin cells. Its profound antioxidant properties can lessen inflammation that is associated with the damaging effects of free radicals.
May Improve Psoriasis
According to this study, it’s as effective as the leading pharmaceutical at treating psoriasis, and without side effects. NAD+ mitigates cellular damage and lessens inflammation, which leads to a visible improvement in the skin.
RELATED PRODUCTS
Testing
Videos
"I have a skincare product that I am really loving right now & it's a mix between a skincare product & a supplement." - Claudia Glows (Length: 7:37)
"This will really help maintain your levels of collagen." - Madison (Length: 4:38)
"It feels like I'm putting liquid gold on my arm." - Madison (Length: 4:40)
"I wish I could take a bath in it." - Claudia Glows (Length: 3:25)
"I'm amazed at the difference I'm seeing." - Claudia Glows (Length: 2:35)
"Overall, this is a powerhouse of ingredients!" - Claudia Glows (Length: 4:13)
RELATED PRODUCTS
Testimonials
NAD+ levels in the skin drop as we age. Our Renue skin care products utilize Liposomes to deliver NAD+ to all layers of the skin to help fight the effects of aging on the skin.
Clinical research (in humans) at a top university is ongoing now to verify the beneficial effects of these products. In the meantime, we have been hearing of a surprisingly wide variety of benefits to the skin, including lessening of wrinkles and age spots, and improvement in appearance in many skin disorders.
The following are uncompensated testimonials from some of our happy customers.
Sun Damage Greatly Diminished
"I applied the serum and day cream to my face after washing it every morning, and before applying my regular SPF moisturizer, and noticed a difference on my skin about 2 months after I started using it. My skin looks brighter, and some sun spots have definitely gotten lighter. I also noticed that the texture of my skin feels like it has more elasticity to it. I love that the products are very light, and absorb quickly. I can't wait to see the results after using it for longer." - Alexia, Age 38.
Smoother Skin and Less Redness
"I've definitely noticed less redness and smoother skin around my eyes and forehead. I LOVE these products. They are the only ones I'd ever use going forward because I see actual results. Most creams and serums are overly expensive and truly don't do anything. I have spent so much money on luxury facial treatments in the past and now I will not be going back. I love the Renue skin care line." - Caitlin H.
"I have been using Renue for several months on my face, forehead and scalp. Both the serum and the lotion get completely absorbed within minutes. I don't know much about NAD+ but I can tell you it's like pouring the fountain of youth into my tissues. My face is smoother or more even. Skin irritation clears up within minutes.
Even better, I had skin damage from past sunburns on my forehead. Over 8 weeks using Renue, the rough skin reduced in size and then simply went away! Even better, being 53, I have had a bald spot on my crown for 15 years. Still, I decided to try Renue for that too. I took a before picture about 2.5 months ago. Then I took the same photo just last week. There is no question that the hairs are thicker and that some new hairs have returned. Renue restores youthful skin, repairs damage and seems to literally turn back time. These products are in a league of their own." - Chris B.
Inflammatory Dermatitis Improved in 2 Weeks
"I see a big improvement on the skin on my forehead. My other dry patches of my inflammatory dermatitis on my cheeks and redness stayed the same where I didn't use Renue. I am hoping for more improvement continuing with this product. I am so happy. I am finally going to start using it on my whole face." - Liz G.
"Super impressive result. The improvement to my facial skin (& the back of my hands) is absolutely associated with the Renue applications. I had noticed it but when other people started commenting I felt that I had something more concrete to contribute. So in summary this is a remarkable result by any standards. Of course I also take ABS Liposomal NMN & Fisetin amongst a range of other supplements." - Lloyd D.
"I have found great results with the Renue Serum! Most specifically and surprisingly in my spider-veins on my left thigh, something I didn’t expect to happen when I decided to try the serum in the first place (wanted to target my fine lines and discoloration in my facial skin - which btw *did* produce results I am happy with) but nothing as much as the clear reduction of my hereditary varicose veins! This first picture was taken Feb 2nd 2021 when I decided to begin applying it there out of simple curiosity, the second image there is a very significant visual reduction in both vein size length and fading pigment back into my skin. " - Michaela B.
“Renue Transdermal Lotion with Liposomal NAD+ has helped my skin tremendously within the last month that I’ve started using it. I use it at night and my face feels soft and renewed every morning. I’ve struggled with acne and scars and have invested in many products without knowing what the ingredients inside do. I saw potential in Renue’s transdermal lotion because of its ingredients that were scientifically proven to work. Because I believed in the research and science behind the ingredients, I took a dive at this product. I am glad that I found it!” - Jason H.
"I am actually astonished looking at these photos.
The creasing under my eyes and the crease of my smile line are significantly reduced as the pigmentation of many of the small “age” spots on my cheek. Pore size has also shrunk." (after 30 days of use) -Anne D.
"I was using Renue Topical Lotion on my face and neck for about 2 months and noticed that my eyebrows had regrown and were actually darker. I started using Renue Topical Lotion on my hair as well as my face and neck. Note: sun damage is gone. The scalp looks refreshed and I believe there was some hair growth although it is hard to tell in these photos. I see a more pronounced hairline when I look at myself in the mirror. It is my hope that perhaps the hair will darken so it becomes more visible. Over the month I believe that the scalp condition has improved considerably, the sunspots have disappeared and I believe there has been some improvement in hair quality and growth." - Bill N.
This is an amazing product!!!
"Check this out!!! I've been using the day cream only on my left hand (the hand on the right in this pic) for only one week!
The day cream has definitely faded some age spots!!!! It also seems like it's taken some of the wrinkles away. This is an amazing product!!!” - Reba W.
"I wish I had photographed my hands- the dark spots gone; I alway rubbed remaining serum and cream after applying to face as an "after thought"... Then I realized the dark spots are essentially gone! The face texture is more radiant and skin tone improving - I use religiously morning and nighttime. that plus the NMN powder, AMPK activators and resveratrol. I keep at it. Thanks so much. Photo coming soon. " - Mary R., Age 73
"I LOVE the serum and the lotion! I can’t say enough about this holy grail product! For years I’ve struggled with mild eczema and have tried so many products that promise but fail to deliver. Some products actually irritated my skin further but not Renue skin care. It absorbs quickly and the best thing is that my skin feels the benefits for days after a few times of application! Honestly, it doesn’t even feel like my skin it’s so soft and dry patch free! Also I noticed that several old acne scars are fading within 1 month of trial and no more new dark spots pop out ever after, which is totally amazing!" - Chi Z., Age 30
Recent Renue™ Testimonial - Eczema Improvements
1/25/2021 (before photo)
I have suffered from severe eczema on my hands and feet for over 50 years. For years, my hands would itch so bad from deep under the skin that I would have to run extremely hot water over them to calm the itching. Consequently, afterwards, the cycle would repeat; apply cortisone and wear nitrile gloves to heal the inflamed hands which then led to dryness, cracking and bleeding. I have been using steroids by a Dermatologist to "manage" my eczema in addition to changing diet, etc.
I knew that using high percentage steroids for prolonged periods of time is not healthy which led me to research more natural remedies – some worked briefly – some were a waste of time and money. Eventually, my search let me to NAD+ by Alive by Science and I have to say that I am a very satisfied customer! The picture shows Red, swollen hands with bleeding, dry, cracked fingers and knuckles.
2/9/2021 (2 weeks later, after photo)
After applying NAD+ Renue serum and lotion every day for 2 weeks there was remarkable improvement in the condition of my hands. The pictures really do not tell the actual incredible story. From a comfort perspective, the redness is gone along with the swelling itching, dryness, scaling, cracking and inflammation. Aside from the natural age-related condition, my natural pigment has returned with zero evidence of Eczema – I mean no itching, scaling, bleeding, or dryness! Thank you, NAD+ serum and lotion!
Trial
Our Renue™ Lotion was first introduced in May of 2019 and we've received great feedback on it. Our Renue™ Skincare line has since expanded and we are even more excited about the potential of our Renue™ Age Defying Serum for restoring and repairing skin that is ravaged by aging.
We decided to perform our own little trial, and sent out an email to our customer base asking for volunteers that would allow use to use their before and after images in exchange for free product to test. The first 100 people to reply were accepted and were shipped the first bottle of Renue™ Serum just before Thanksgiving 2020.
We were pleased to find that after 30 days, all of the 100 subjects wanted to continue use, and gave us feedback on what they experienced. The overwhelming majority was extremely positive!
Of course these results are mostly subjective and not proof of anything, but we are very encouraged by them, and believe we will be getting a lot of good before/after images like the ones below.
BEFORE & AFTER PHOTOS
Smoother Skin & Sun Damage Diminished
"I applied the serum and day cream to my face after washing it every morning, and before applying my regular SPF moisturizer, and noticed a difference on my skin about 2 months after I started using it. My skin looks brighter, and some sun spots have definitely gotten lighter. I also noticed that the texture of my skin feels like it has more elasticity to it. I love that the products are very light, and absorb quickly. I can't wait to see the results after using it for longer." - Alexia, Age 38.
Smoother Skin & Hair Growth
"I have been using Renue for several months on my face, forehead and scalp. Both the serum and the lotion get completely absorbed within minutes. I don't know much about NAD+ but I can tell you it's like pouring the fountain of youth into my tissues. My face is smoother or more even. Skin irritation clears up within minutes. Even better, I had skin damage from past sunburns on my forehead. Over 8 weeks using Renue, the rough skin reduced in size and then simply went away!
Even better, being 53, I have had a bald spot on my crown for 15 years. Still, I decided to try Renue for that too. I took a before picture about 2.5 months ago. Then I took the same photo just last week. There is no question that the hairs are thicker and that some new hairs have returned. Renue restores youthful skin, repairs damage and seems to literally turn back time. These products are in a league of their own." - Chris B.
Improvement in Skin Texture & Wrinkles
"Super impressive result. The improvement to my facial skin (& the back of my hands) is absolutely associated with the Renue applications. I had noticed it but when other people started commenting I felt that I had something more concrete to contribute. So in summary this is a remarkable result by any standards. Of course I also take ABS Liposomal NMN & Fisetin amongst a range of other supplements." - Lloyd D.
Smoother Skin and Less Redness
"I've definitely noticed less redness and smoother skin around my eyes and forehead. I LOVE these products. They are the only ones I'd ever use going forward because I see actual results. Most creams and serums are overly expensive and truly don't do anything. I have spent so much money on luxury facial treatments in the past and now I will not be going back. I love the Renue skin care line." - Caitlin H.
Inflammatory Dermatitis Improved in 2 Weeks
"I see a big improvement on the skin on my forehead. My other dry patches of my inflammatory dermatitis on my cheeks and redness stayed the same where I didn't use Renue. I was testing it out on my forehead alone first. I am hoping for more improvement continuing with this product. I am so happy. I am finally going to start using it on my whole face." - Liz G.
Pigmentation and Pore Improvements
I am actually astonished looking at these photos. The creasing under my eyes and the crease of my smile line are significantly reduced as the pigmentation of many of the small “age” spots on my cheek. Pore size has also shrunk. (after 30 days of use) - Anne D.
Recent Renue™ Testimonial - Eczema Improvements
1/25/2021 (before photo)
I have suffered from severe eczema on my hands and feet for over 50 years. For years, my hands would itch so bad from deep under the skin that I would have to run extremely hot water over them to calm the itching. Consequently, afterwards, the cycle would repeat; apply cortisone and wear nitrile gloves to heal the inflamed hands which then led to dryness, cracking and bleeding. I have been using steroids by a Dermatologist to "manage" my eczema in addition to changing diet, etc.
I knew that using high percentage steroids for prolonged periods of time is not healthy which led me to research more natural remedies – some worked briefly – some were a waste of time and money. Eventually, my search let me to NAD+ by Alive by Science and I have to say that I am a very satisfied customer! The picture shows Red, swollen hands with bleeding, dry, cracked fingers and knuckles.
2/9/2021 (2 weeks later, after photo)
After applying NAD+ Renue serum and lotion every day for 2 weeks there was remarkable improvement in the condition of my hands. The pictures really do not tell the actual incredible story. From a comfort perspective, the redness is gone along with the swelling itching, dryness, scaling, cracking and inflammation. Aside from the natural age-related condition, my natural pigment has returned with zero evidence of Eczema – I mean no itching, scaling, bleeding, or dryness! Thank you, NAD+ serum and lotion!
Bill's 30 Day Results - Sunspots Diminished
Here is an image we received recently from a Renue™ trial participant, Bill, who has been using the Renue™ Age Defying Serum in the morning and evening, 4 pumps each time, massaging it into the scalp.
There is a noticeable diminishment in his sunspots and scalp hyperpigmentation, as well as possible hair growth - and all in a span of one month!
Here you can read about Bill's experience, in his own words.
Background
I was using Renue Topical Lotion on my face and neck for about 2 months and noticed that my eyebrows had regrown and were actually darker. Due to my hypothyroid condition, my eyebrows had thinned out to a point where you could barely tell I had any. This discovery encourage me to allow my hair to grow back (until this time I was shaving my head). I started using Renue Topical Lotion on my hair as well as my face and neck. I felt I saw some improvement. I wanted to investigate further for products similar to the lotion so I went on the Alive by Science website and notice they were conducting a trial for the Renue Age Defying Serum. I immediately applied to be a part of the trial. I received the first shipment of product, Renue Age Defying Serum, on November 20, 2020.
Procedure
I use the product both morning and evening. I use 4 pumps each time, messaging the serum into the scalp. Photographs for November 20, 2020 Please note the sun damage at the crown of the head.
December 10, 2020 Photographs - note: sun damage continues to disappear. Although it is hard to tell I believe that I am seeing new hair growth.
Note: sun damage is gone. The scalp looks refreshed and I believe there was some hair growth although it is hard to tell in these photos. I see a more pronounced hairline when I look at myself in the mirror. It is my hope that perhaps the hair will darken so it becomes more visible.
Over the month I believe that the scalp condition has improved considerably, the sunspots have disappeared and I believe there has been some improvement in hair quality and growth. I received the second shipment of product on December 19, 2020. Along with the Renue Age Defying Serum, I received a canister of Renue Topical Lotion. I will continue the regime of twice a day application with the Renue Age Defying Serum and I will apply the Renue Topical lotion once a day in the mornings. I look forward to the next month with anticipation of more improvement with scalp conditioning and hair growth.
Transdermal Delivery
Transdermal delivery is a method of applying medications or active ingredients through the skin. It's convenient and can improve product delivery, absorption and effectiveness. The skin's protective barrier creates a challenge for transdermal delivery. As a result, liposomes can be used to carry ingredients past the skin's barrier. (Source)
Some liposomes work to deliver nutrients by diffusion, meaning the surface of the skin (stratum corneum) absorbs them, and then transfers the active ingredients directly from the liposomes to the skin.
In addition, lecithin in often used in liposome formulations and it increases the permeability of the skin's surface or barrier, enhancing transdermal delivery. (Source)
Liposomes
Liposomes are an advanced delivery vehicle, protecting a much higher percentage of active ingredients from digestion, while slowly releasing the payload into the bloodstream.
- liposomes improve permeation of products to the site where applied, for localized treatment (in the skin)
- liposomes also offer systemic nutrient delivery (in the body)
- liposomal topicals and transdermals can optimize cellular uptake and effectiveness
What Liposomes Are Made Of
A Liposome is made up of a spherical vesicle with the inner contents containing the active ingredients, which are protected by an outer layer comprised of tiny fat-like particles, called the Phospholipid Layer. Liposomes have the ability to carry ingredients that are hydrophobic ("water-fearing") and hydrophilic ("water-loving"). (Source)
Advantages to Transdermal Liposomal Delivery
- superior stability of active ingredients
- higher absorption and greater efficacy
- may circumvent first-pass metabolism - meaning, more of the nutrients will reach your bloodstream
- enhanced skin permeability, allowing more actives past the outer layer & deeper into the cells
- the dose is slowly released so the supplement's concentration level can stay fairly constant in the body
Safety of Liposomal Delivery
Liposomes closely resemble the structure of cell membranes, and as a result the
"Liposomes are valued for their biological and technological advantages, and are considered to be the most successful drug-carrier systems known to date." - International Journal of Nanomedicine, Liposomes As Nanomedical Devices
How Are they Absorbed?
The inclusion of lipid vesicles into lotions can enhance their stability, prolong active product release, enhance transdermal permeability, and increase localization of the active within the skin. - Hydrogels and Their Combination with Liposomes, Niosomes, or Transfersomes for Dermal and Transdermal Drug Delivery
Advantages of Transdermal NAD+ on Aging Skin
Accelerated Skin Aging
Accelerated skin aging is common, and it's important to understand some of the causes, in order to address them. Daily exposure to solar radiation contributes to cellular dysfunction within the skin. This results in accelerated skin aging (photoaging), and disturbances to the normal hormeostatic state of the skin. *Homeostasis: This is the condition of optimal functioning within your skin.Skin's Appearance & Evidence of Damage
Evidence of damage may appear in numerous ways. Chronological aging is characterized by thinning of the skin, which appears as dryness and wrinkles. UV-damaged skin has a thicker, leathery-like appearance with deeper wrinkles and pigmentation issues. (Source) Cellular NAD+ pools are lower in aged skin. Mitochondria are one of the primary targets of damage from chronological and UV-induced skin aging. (Source, Source)"Several studies have directly or indirectly linked mitochondrial dysfunction to both chronological and photo-aging of the skin." - Mitochondria in Skin Health, Aging, and Disease, Cell Death & Disease
Mitochondrial Dysfunction & Depletion of NAD+
An increase in oxidative stress contributes to the depletion of NAD+ and ATP (a molecule that carries energy within a cell). The damage contributes to mitochondrial dysfunction in both the short-term & long-term, creating a
NAD+ Regulates Mitochondrial Maintenance
Mitochondrial maintenance through mitophagy (selectively eliminating the defective mitochondria) and mitochondrial biogenesis (synthesis and production of new mitochondria) is vital to cellular homeostasis and health. (Source) NAD+ regulates mitochrondrial maintenance. In this study, when levels of NAD+ in old mice were raised, their mitochondrial function was restored to that of young mice. (Source)"NAD+ and its primary precursor nicotinamide have been known for some time to impact skin homeostasis based on linkages to dietary requirements, treatment of various inflammatory conditions, photoaging..." - The evolving role of the NAD+/nicotinamide metabolome in skin homeostasis, cellular bioenergetics, and aging
Increasing NAD+ Levels in the Skin
Delivery of NAD+ through transdermal liposomal serums and lotions, is an optimal way to safely raise levels of NAD+ in the skin. In dermal fibroblasts (cells within the dermis), nicotinamide protects against oxidative stress, glycolisis, oxidative phosphorylation and increases mitochondrial efficiency. (Source) Low NAD+ levels are common in aging skin, and directly contribute to impairement in mitochondrial function and ATP production. Numerous factors contribute to the impaired hormeostatic state of the skin and numerous methods can be used to treat it. Targeted nutrient therapy with NAD+ and other active ingredients, delivered through transdermal liposomal skincare formulations, is one way to address numerous skin-aging issues. Raising NAD+ levels can create a positive cascading effect on numerous processes."Bioactive compounds targeting the mitochondria have proved effective against age-related as well as UV-induced skin damage, in addition to different skin diseases with mitochondrial involvement." - The evolving role of the NAD+/nicotinamide metabolome in skin homeostasis, cellular bioenergetics, and aging
Renue works at the cellular level
The Renue™ skincare line offers an advanced skin treatment system.
