Renue Blue™ Face Cream with Methylene Blue, NAD⁺, NMN, NR (Liposomal) – Currently Expected Back In Stock By Late May – RENUE BY SCIENCE

Renue Blue™ Face Cream with Methylene Blue, NAD⁺, NMN, NR (Liposomal) – Currently Expected Back In Stock By Late May

$49.95

Renue Blue™ Face Cream is a multi-tasking powerhouse formulated to restore skin elasticity, increase youthful suppleness, preserve and rejuvenate skin’s surface & visibly enhance firmness. Our reformulation now includes FOUR TIMES the Methylene Blue than previous versions.

2 mL provides ▸100 mg NAD⁺ Complex ▸10 mg Resveratrol ▸10 mg Apocynin ▸ Methylene Blue

2 Ounces

Per Bottle

Recommended

2 Pumps

Liposomal

Face Cream

2 Ounces

Per Bottle

Recommended

2 Pumps

Liposomal

Face Cream

 

Out of stock - coming soon!

NEW Renue Blue™ Liposomal Face Cream with Methylene Blue

Renue Blue™ Face Cream with Methylene Blue and NAD⁺ Complex, features our proprietary liposomal delivery system for faster and deeper penetration of key ingredients into the skin’s surface for deep cellular renewal.

Light, but deeply nourishing, this cream hydrates the skin and works as a protective shield against environmental factors. Bring your skin back to life with this fast-absorbing formula packed with Methylene Blue, NAD⁺, NMN, NR, Resveratrol, Apocynin, powerful nutrients, antioxidants and cell-renewing Alpha Lipoic Acid.

NAD⁺ COMPLEX

NAD⁺ Complex is a powerful trio, containing NAD⁺, NMN and NR. As you age, your skin requires higher levels of NAD⁺ to combat damage and keep your skin in a youthful and healthy state. Aging is directly associated with lower NAD⁺ levels in the skin. Delivery of NAD⁺ and NAD⁺ boosters through liposomal skincare is the optimal way to safely raise levels of NAD⁺ in the skin.

METHYLENE BLUE

Methylene Blue has been studied for a wide range of ailments, many of which are aging-related illnesses, and there are currently over 20,000 studies on Pubmed. One study conducted at the University of Maryland tested the potential dermal anti-aging benefits of four antioxidants, one of which was Methylene Blue.

Among all of the antioxidants studied, Methylene Blue was by far, the most effective.

University of Maryland Study

The study was conducted by the Department of Cell Biology & Molecular Genetics, at the University of Maryland.

In the study, researchers tested out four antioxidants on the skin, one of which was Methylene Blue. The second one was N. Acetyl Cysteine, or NAC, a very popular antioxidant, often taken as a supplement. The last two were MitoQ and mTEM - both of which are mitochondrial targeting antioxidants.

They applied each one topically to skin fibroblasts of healthy middle-aged adults, adults 80 and older and from people with progeria.

For most studies, skin fibroblasts are obtained through a non-invasive procedure that involves numbing at the site and taking a punch skin biopsy sample.

Progeria is an extremely rare genetic condition characterized by dramatic and rapid aging. It causes severe hardening of the arteries at a young age, and often those afflicted don't live past their teenage years.

Some researchers believe that Progeria may hold the key to understanding the precise causes of aging - so that it can be slowed down.

For this study, the Progeria fibroblasts were used as an accelerated model for normal aging - because they share many of the features in common with normal aging.

One part of the study looked at the effectiveness of these antioxidants to decrease oxidative stress. Oxidative stress plays a major role in the aging process in the skin, much of which is driven by UV exposure.

Among all of the antioxidants studied, Methylene Blue was the most effective.

It reduced mitochondrial reactive oxygen species, and promoted skin cell proliferation - which involves an increase in the cell division rate and that leads to a higher number of new, healthy cells created during cell turn-over.

The normal skin and the progeria skin treated with the Methylene Blue, showed much higher skin proliferation levels.

Research shows that as a person ages, proliferation of cells in the basal (or deepest) layer reduces. The epidermis (or the outer layer) then becomes thinner. The nutrition supply to the outer layer then weakens because of dysfunction in the deeper layers.

This process of decreased proliferation in the skin, is associated with senescence. Senescent cells, also known as zombie cells, can cause a lot of damage. They are cells that eventually stop multiplying, yet they don't die off like they should. Instead, they remain in the body and continue to release damaging chemicals that trigger inflammation.

In the second part of the study, cellular senescence was examined.

Different fibroblasts were used and treated with Methylene Blue. Two fibroblasts from people over 80 were used and two fibroblasts from people under 30 were used.

The over 80 fibroblasts showed increases in biomarkers of senescence. When treated with Methylene Blue, there was a reduction in cellular senescence, especially notable for the older skin fibroblasts. This showed that Methylene Blue is effective at reducing cellular senescence.  

The study revealed that skin treated with Methylene Blue had an increase in skin thickness and improved levels of skin hydration.

This is important because skin thickness and loss of hydration are issues of aging skin. Dermal thickness decreases by about 6% every decade.

Source: Anti-Aging Potentials of Methylene Blue for Human Skin Longevity

Among all of the antioxidants studied, Methylene Blue was the most effective.

The Methylene Blue-treated skin showed a greater reduction in DNA damage, leading to cell rejuvenation.

There was an increase the cell division rate, leading to a higher number of healthy new cells created during cellular turnover.

In addition, there was less senescence - and a slower rate of cell death, indicating that skin cells became healthier and lived longer.

There was also improved hydration levels and dermal thickness was increased.

Study: Anti-Aging Potentials of Methylene Blue for Human Skin Longevity https://www.nature.com/articles/s41598-017-02419-3

Fighting against Skin Aging The Way from Bench to Bedside https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047276/

The evolving role of the NAD+/nicotinamide metabolome in skin homeostasis, cellular bioenergetics, and aging https://sci-hub.do/10.1016/j.dnarep.2014.04.005

NAD in Skin: Therapeutic Approaches for Niacin https://sci-hub.do/10.2174/138161209787185760

Characteristics of the Aging Skin https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840548/

Xiong, ZM, O’Donovan, M., Sun, L., et al. Anti-Aging Potentials of Methylene Blue for Human Skin Longevity. Sci Rep 7, 2475 (2017) (https://doi.org/10.1038/s41598-017-02419-3). Licensed under CC-BY 4.0 (https://creativecommons.org/licenses/by/4.0/). Disclaimer – Neither the license nor link to the foregoing publication constitutes or implies any sponsorship or affiliation with, or endorsement or approval of Renue By Science by the authors.

 

RENUE™ - 2 Step Skin Rejuvenation Protocol 

 

These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure, or prevent any disease.

 

 

 

Ingredients

Active Liposomal Ingredients

  • NAD+ Complex™: Nicotinamide Adenine Dinucleotide (NAD+) · Nicotinamide Mononucleotide (NMN) · Nicotinamide Riboside (NR)
  • Methylene Blue
  • Resveratrol
  • Apocynin
  • ALA (Alpha-Lipoic Acid)
  • HLA (Hyaluronic Acid)

Helianthus Annuus (from Sunflower Lecithin) · Glycerin · Aloe Barbadensis (Aloe Vera) · Coconut Fruit Juice · Chondrus Crispus (Seaweed Extract) · Sesamum Indicum (Sesame Seed Extract) · Prunus Amygdalus Dulcis (Sweet Almond Oil) · Hyaluronic Acid (HLA) · Alpha-Lipoic-Acid (ALA) · Rosmarinus Officinalis (Rosemary) · Citric Acid

Emollients & Stabilizers

Tocopherols (Vitamin E) · Propylene Glycol · Cetearyl Alcohol · Glyceryl Stearate · Potassium Sorbate · Sodium Benzoate

 

Resveratrol

“The Longevity Molecule"

Resveratrol is a stilbenoid polyphenol synthesized by plants in response to stressful stimuli and is protective in aging. 9, 10, 6

Its broad-spectrum properties (antimicrobial, anti-inflammatory, antioxidant and anti-aging) make it a potent bioactive for dermatological application by limiting the effects of cellular aging. 11

Its antioxidant activity (95%) is higher than vitamin E (65%) and C (37%) and has been shown to be active in neutralizing and inhibiting the formation of reactive oxygen species. 6, 12

Apocynin

The Skin Cell Tonic”

Apocynin, a natural vanilloid compound, has emerged as a bioactive phytochemical with potent anti-inflammatory properties for the skin. 13

A new paper published in Nature, found that declining levels of a collagen protein called COL17A1 (Collagen 17), cause our skin to develop wrinkles, sag and lose elasticity. 4

Apocynin was able to restore levels of Collagen 17 and repair damaged skin, leading scientists to believe it’s possible to reverse our skin’s timeline at the cellular level. 14

NAD+

"The Youth Molecule"

May Improve Rosacea

According to research Topical NAD+ has been shown to improve metabolism of skin cells. Its profound antioxidant properties can lessen inflammation that is associated with the damaging effects of free radicals.

May Improve Psoriasis

According to this study, it’s as effective as the leading pharmaceutical at treating psoriasis, and without side effects. NAD+ mitigates cellular damage and lessens inflammation, which leads to a visible improvement in the skin.

More about Resveratrol

More about Apocynin

More about NAD+

Usage

Press the depression on the top of the jar with index finger 1-3 times, then sweep the formula with the tip of the ring finger. Smooth onto your face, neck and décolletage to quickly infuse your skin with nutrient dense, concentrated liposomes for a youth-restoring boost and enjoy intensive hydration throughout the day. Use with Renue™ Age Defying Serum.

Videos

"I have a skincare product that I am really loving right now & it's a mix between a skincare product & a supplement." - Claudia Glows (Length: 7:37)

"This will really help maintain your levels of collagen." - Madison (Length: 4:38)

"It feels like I'm putting liquid gold on my arm." - Madison (Length: 4:40)

 

"I wish I could take a bath in it." - Claudia Glows (Length: 3:25)

"I'm amazed at the difference I'm seeing." - Claudia Glows (Length: 2:35)

"Overall, this is a powerhouse of ingredients!" - Claudia Glows (Length: 4:13)

 

Trial Results

Our Renue NAD+ Lotion was first introduced in May of 2019 and we've received great feedback on it. Our skincare line has since expanded and we are even more excited about the potential of our face Serum for restoring and supporting skin health through aging.

We decided to perform our own little trial, and sent out an email to our customer base asking for volunteers that would allow use to use their before and after images in exchange for free product to test. The first 100 people to reply were accepted and were shipped the first bottle of serum just before Thanksgiving 2020.

Renue Trial
Renue Serum Trial Results

We were pleased to find that after 30 days, all of the 100 subjects wanted to continue use, and gave us feedback on what they experienced. The overwhelming majority was extremely positive!

Of course these results are mostly subjective and not proof of anything, but we are very encouraged by them, and believe we will be getting a lot of good before/after images like the ones below.

Transdermal Delivery

Transdermal delivery is a method of applying medications or active ingredients through the skin. It's convenient and can improve product delivery, absorption and effectiveness. The skin's protective barrier creates a challenge for transdermal delivery. As a result, liposomes can be used to carry ingredients past the skin's barrier. (Source)

Liposomes

Liposomes are an advanced delivery vehicle, protecting a much higher percentage of active ingredients from digestion, while slowly releasing the payload into the bloodstream.

  • liposomes improve permeation of products to the site where applied, for localized treatment (in the skin)
  • liposomes also offer systemic nutrient delivery (in the body)
  • liposomal topicals and transdermals can optimize cellular uptake and effectiveness

What Liposomes Are Made Of

A Liposome is made up of a spherical vesicle with the inner contents containing the active ingredients, which are protected by an outer layer comprised of tiny fat-like particles, called the Phospholipid Layer. Liposomes have the ability to carry ingredients that are hydrophobic ("water-fearing") and hydrophilic ("water-loving"). (Source)

Advantages to Transdermal Liposomal Delivery

  • superior stability of active ingredients
  • higher absorption and greater efficacy
  • may circumvent first-pass metabolism - meaning, more of the nutrients will reach your bloodstream
  • enhanced skin permeability, allowing more actives past the outer layer & deeper into the cells
  • the dose is slowly released so the supplement's concentration level can stay fairly constant in the body

Safety of Liposomal Delivery

Liposomes closely resemble the structure of cell membranes, and as a result the body recognizes them as safe and friendly substances (they are biocompatible). Liposome-formulated drugs are used routinely to treat a wide range of illnesses. Nutraceutical or nutritional liposomes can act as both a treatment as well as preventive care. The nutritional industry’s use of liposomes is expected to grow rapidly in the next 5–10 years. (Source, Source)

"Liposomes are valued for their biological and technological advantages, and are considered to be the most successful drug-carrier systems known to date." - International Journal of Nanomedicine, Liposomes As Nanomedical Devices

How Are they Absorbed?

Some liposomes work to deliver nutrients by diffusion, meaning the surface of the skin (stratum corneum) absorbs them, and then transfers the active ingredients directly from the liposomes to the skin. In addition, lecithin in often used in liposome formulations and it increases the permeability of the skin's surface or barrier, enhancing transdermal delivery. (Source)
The inclusion of lipid vesicles into lotions can enhance their stability, prolong active product release, enhance transdermal permeability, and increase localization of the active within the skin. - Hydrogels and Their Combination with Liposomes, Niosomes, or Transfersomes for Dermal and Transdermal Drug Delivery

Advantages of Transdermal NAD+ on Aging Skin

Accelerated Skin Aging

Accelerated skin aging is common, and it's important to understand some of the causes, in order to address them. Daily exposure to solar radiation contributes to cellular dysfunction within the skin. This results in accelerated skin aging (photoaging), and disturbances to the normal hormeostatic state of the skin. *Homeostasis: This is the condition of optimal functioning within your skin.

Skin's Appearance & Evidence of Damage

Evidence of damage may appear in numerous ways. Chronological aging is characterized by thinning of the skin, which appears as dryness and wrinkles. UV-damaged skin has a thicker, leathery-like appearance with deeper wrinkles and pigmentation issues. (Source) Cellular NAD+ pools are lower in aged skin. Mitochondria are one of the primary targets of damage from chronological and UV-induced skin aging. (Source, Source)
"Several studies have directly or indirectly linked mitochondrial dysfunction to both chronological and photo-aging of the skin." - Mitochondria in Skin Health, Aging, and Disease, Cell Death & Disease

Mitochondrial Dysfunction & Depletion of NAD+

An increase in oxidative stress contributes to the depletion of NAD+ and ATP (a molecule that carries energy within a cell). The damage contributes to mitochondrial dysfunction in both the short-term & long-term, creating a cumulative impact.

NAD+ Regulates Mitochondrial Maintenance

Mitochondrial maintenance through mitophagy (selectively eliminating the defective mitochondria) and mitochondrial biogenesis (synthesis and production of new mitochondria) is vital to cellular homeostasis and health. (Source) NAD+ regulates mitochrondrial maintenance. In this study, when levels of NAD+ in old mice were raised, their mitochondrial function was restored to that of young mice. (Source)
"NAD+ and its primary precursor nicotinamide have been known for some time to impact skin homeostasis based on linkages to dietary requirements, treatment of various inflammatory conditions, photoaging..." - The evolving role of the NAD+/nicotinamide metabolome in skin homeostasis, cellular bioenergetics, and aging

Increasing NAD+ Levels in the Skin

Delivery of NAD+ through transdermal liposomal serums and lotions, is an optimal way to safely raise levels of NAD+ in the skin. In dermal fibroblasts (cells within the dermis), nicotinamide protects against oxidative stress, glycolisis, oxidative phosphorylation and increases mitochondrial efficiency. (Source) Low NAD+ levels are common in aging skin, and directly contribute to impairement in mitochondrial function and ATP production. Numerous factors contribute to the impaired hormeostatic state of the skin and numerous methods can be used to treat it. Targeted nutrient therapy with NAD+ and other active ingredients, delivered through transdermal liposomal skincare formulations, is one way to address numerous skin-aging issues. Raising NAD+ levels can create a positive cascading effect on numerous processes.
"Bioactive compounds targeting the mitochondria have proved effective against age-related as well as UV-induced skin damage, in addition to different skin diseases with mitochondrial involvement." - The evolving role of the NAD+/nicotinamide metabolome in skin homeostasis, cellular bioenergetics, and aging

Renue works at the cellular level

The Renue™ skincare line offers an advanced skin treatment system.

The delivery method is vital when it comes to skincare and supplements. What sets this skincare line apart, in addition to the potent ingredients and scientifically advanced formulation, is its superior mode of delivery. Liposomes safely carry the active ingredients, which include a NAD+ Complex (NAD+, NMN & NR), Resveratrol and Apocynin, past the outer skin barrier and deep into your cells. The formulation allows for these potent ingredients to reach the target site before releasing them to offer a targeted skin treatment. Learn More.

History of Liposomal Delivery

Liposomes were first discovered in 1965 and soon after were proposed as drug delivery systems. For the last five decades, advancements in this field have led to numerous clinical trials on liposomes for delivery of anti-fungal, antibiotic drugs, delivery of gene medicines, anesthetics and anti-inflammatory medications. This is an established technology, with a variety of types of liposomes being brought to market. (Source)